Similar studies for GEO DataSets (Select 200029989) - GEO DataSets

Select item 2000299891.

Transcriptome Profiling and Sequencing of differentiated Human Hematopoietic Stem cells Reveal Lineage Specific Expression and Alternative Splicing of Genes

(Submitter supplied) Hematopoietic differentiation is strictly regulated by complex network of transcription factors that are controlled by ligands binding to cell surface receptors. Disruptions of the intricate sequences of transcriptional activation and suppression of multiple genes cause hematological diseases, such as leukemias, myelodysplastic syndromes or myeloproliferative syndromes. From a clinical standpoint, deciphering the pattern of gene expression during hematopoiesis may help unravel disease-specific mechanisms in hematopoietic malignancies. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5188
12 Samples

Download data: CEL

Series

Accession:: GSE29989

ID:: 200029989

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000152072.

Genome wide mapping of the haematopoietic system transcriptome

(Submitter supplied) Recent advances in high density oligonucleotides microarray technology have brought solutions for molecular profiling of human samples at an unprecedented resolution. We mapped whole blood RNA from healthy volunteers and CD34+ from cytapheresis to Human Exon ST 1.0 microarrays. We compared mature blood cells samples with immature CD34+ samples and each of these compartiement with a broad panel of solid tissues. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5188
7 Samples

Download data: CEL, CHP

Series

Accession:: GSE15207

ID:: 200015207

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000532633.

Expression profiling of human CD34+ cells derived from mobilized peripheral blood samples after overexpression of MEIS1B or MEIS1D

(Submitter supplied) MEIS1 is a transcription factor expressed in hematopoietic stem and progenitor cells (HSPC) and in mature megakaryocytes. In contrast to its role in leukemogenesis, the role of MEIS1 in normal hematopoiesis is largely unknown. We show that MEIS1 can direct human hematopoietic progenitors towards a megakaryocyte-erythroid progenitor (MEP) fate. Ectopoic expression of MEIS1 in CD34+ cells resulted in increased erythroid differentiation at the expense of granulocyte and monocyte (GM) differentiation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
9 Samples

Download data: TXT

Series

Accession:: GSE53263

ID:: 200053263

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000346054.

Inferring rules of lineage commitment in haematopoiesis

(Submitter supplied) Fractionation of EML cells isolated based on surface expression of immunophenotypic markers reveals the existence of a subpopulation that has undergone spontaneous commitment to an erythroid fate. Uncommitted fractions were compared to committed cells, derived from both spontaneous (EryCP) and cytokine-driven (Ediff) commitment.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
26 Samples

Download data: TXT

Series

Accession:: GSE34605

ID:: 200034605

Select item 2000291155.

Microarray Expression Data from Haematopoietic Differentiated Human Embryonic Stem Cells

(Submitter supplied) The underlying mechanisms which are responsible and govern early haematopoietic differentiation during development are poorly understood. Gene expression comparison between pluripotent human embryonic stem cells and earliest haematopoietic progenitors may reveal novel transcripts and pathways and provide crucial insight into early haematopoietic lineage specification and development. Understanding of transcriptional cues that direct differentiation of human embryonic stem cells (hESC) to defined and functional cell types is essential for their future clinical applications. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE29115

ID:: 200029115

Select item 2000026666.

Human Hematopoietic Stem Cell (HSC) and Progenitor Cell (HPC) Expression Profilies

(Submitter supplied) The global gene expression profiles of human umbilical cord blood and adult bone marrow CD34+CD33-CD38-Rho(lo)c-kit+ cells, enriched for hematopoietic stem/progenitor cells (HSC) with CD34+CD33-CD38-Rho(hi) cells, enriched in committed hematopoietic progenitor cells (HPC), were compared to identify candidate regulators of HSC self-renewal versus differentiation fate decisions. Keywords: parallel sample

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS1230 GDS1231
Platforms:: GPL96 GPL97
36 Samples

Download data: CEL, EXP

Series

Accession:: GSE2666

ID:: 200002666

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 12317.

Hematopoietic stem cell and progenitor cell comparison (HG-U133B)

Comparison of CD34+CD33-CD38-Rho(lo)c-kit+ cells, enriched for hematopoietic stem/progenitor cells (HSC), to CD34+CD33-CD38-Rho(hi) cells, enriched for committed hematopoietic progenitor cells (HPC). Cells obtained from umbilical cord blood and bone marrow. Provides insight into control of HSC fate.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 cell type, 2 tissue sets

Platform:: GPL97
Series:: GSE2666
18 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS1231

ID:: 1231

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 12308.

Hematopoietic stem cell and progenitor cell comparison (HG-U133A)

Comparison of CD34+CD33-CD38-Rho(lo)c-kit+ cells, enriched for hematopoietic stem/progenitor cells (HSC), to CD34+CD33-CD38-Rho(hi) cells, enriched for committed hematopoietic progenitor cells (HPC). Cells obtained from umbilical cord blood and bone marrow. Provides insight into control of HSC fate.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 cell type, 2 tissue sets

Platform:: GPL96
Series:: GSE2666
18 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS1230

ID:: 1230

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000175869.

microRNA expression profiling of human myeloid precursors

(Submitter supplied) Hemopoiesis entails a series of hierarchically organized events that proceed throughout cell specification and terminates with cell differentiation. Commitment needs the transcription factors effort that, in concert with microRNAs, drives cell fate specification, answering to promiscuous patterns of gene expression by turning on lineage-specific genes and repressing alternate lineage transcripts. Therefore microRNAs and mRNAs cooperate to direct cell fate decisions. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL9019
5 Samples

Download data: SDS

Series

Accession:: GSE17586

ID:: 200017586

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001280310.

Gene expression in human myeloid cells

(Submitter supplied) Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where pluripotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. This study aimed at investigating the genomic expression during myeloid differentiation through a computational approach that integrates gene expression profiles with functional information and genome organization. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
20 Samples

Download data: CEL

Series

Accession:: GSE12803

ID:: 200012803

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010068911.

An integrated global regulatory network of hematopoietic precursor cell self-renewal and differentiation

(Submitter supplied) The mammalian blood system is a hierarchically structured tissue. Hematopoietic stem cells (HSC) reside at the top of this hierarchy and the HSC-derived progenitor cells (HPC) have capacities for both differentiation and self-renewal. Systematic study of the regulatory mechanisms of HSC self-renewal and differentiation is fundamentally important for understanding hematopoiesis and for manipulating HSCs for therapeutic purposes. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: XLSX

Series

Accession:: GSE100689

ID:: 200100689

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003175712.

A Systematic Comparison and Evaluation of High Density Exon Arrays and RNA-seq technology in Unraveling the Peripheral Blood Transcriptome of Sickle Cell Disease.

(Submitter supplied) Sickle cell transcriptome was analyzed using whole blood clinical specimens on the Affymetrix Human Exon 1.0 ST arrays and Illumina’s deep sequencing technologies. Data analysis indicated a strong concordance (R=0.64) between exon array and RNA-seq in both gene level and exon level expression of transcripts. The magnitude of fold changes in the expression levels for the differentially expressed genes (p<0.05) was found to be higher in RNA-seq than microarrays. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5188
10 Samples

Download data: CEL

Series

Accession:: GSE31757

ID:: 200031757

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008145313.

Reprogramming-associated aberrant DNA methylation determines hematopoietic differentiation capacity of human induced pluripotent stem cells [iPSCs_expression_with_different_culture_conditions]

(Submitter supplied) The variation among induced pluripotent stem cells (iPSCs) in their differentiation capacity to specific lineages is frequently attributed to somatic memory. In this study, we compared hematopoietic differentiation capacity of 35 human iPSC lines derived from four different tissues and four embryonic stem cell lines. The analysis revealed that hematopoietic commitment capacity (PSCs to hematopoietic precursors) is correlated with the expression level of the IGF2 gene independent of the iPSC origins. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
8 Samples

Download data: TXT

Series

Accession:: GSE81453

ID:: 200081453

Select item 20008145214.

Reprogramming-associated aberrant DNA methylation determines hematopoietic differentiation capacity of human induced pluripotent stem cells [iPSCs_methylation 2]

(Submitter supplied) The variation among induced pluripotent stem cells (iPSCs) in their differentiation capacity to specific lineages is frequently attributed to somatic memory. In this study, we compared hematopoietic differentiation capacity of 35 human iPSC lines derived from four different tissues and four embryonic stem cell lines. The analysis revealed that hematopoietic commitment capacity (PSCs to hematopoietic precursors) is correlated with the expression level of the IGF2 gene independent of the iPSC origins. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
12 Samples

Download data: TXT

Series

Accession:: GSE81452

ID:: 200081452

Select item 20007509615.

Reprogramming-associated aberrant DNA methylation determines hematopoietic differentiation capacity of human induced pluripotent stem cells [iPSC_ESC_lines]

(Submitter supplied) The variation among induced pluripotent stem cells (iPSCs) in their differentiation capacity to specific lineages is frequently attributed to somatic memory. In this study, we compared hematopoietic differentiation capacity of 35 human iPSC lines derived from four different tissues and four embryonic stem cell lines. The analysis revealed that hematopoietic commitment capacity (PSCs to hematopoietic precursors) is correlated with the expression level of the IGF2 gene independent of the iPSC origins. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
13 Samples

Download data: TXT

Series

Accession:: GSE75096

ID:: 200075096

Select item 20007509516.

Reprogramming-associated aberrant DNA methylation determines hematopoietic differentiation capacity of human induced pluripotent stem cells [Erythroid_lines]

(Submitter supplied) The variation among induced pluripotent stem cells (iPSCs) in their differentiation capacity to specific lineages is frequently attributed to somatic memory. In this study, we compared hematopoietic differentiation capacity of 35 human iPSC lines derived from four different tissues and four embryonic stem cell lines. The analysis revealed that hematopoietic commitment capacity (PSCs to hematopoietic precursors) is correlated with the expression level of the IGF2 gene independent of the iPSC origins. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
6 Samples

Download data: TXT

Series

Accession:: GSE75095

ID:: 200075095

Select item 20007496717.

Reprogramming-associated aberrant DNA methylation determines hematopoietic differentiation capacity of human induced pluripotent stem cells

(Submitter supplied) The variation among induced pluripotent stem cells (iPSCs) in their differentiation capacity to specific lineages is frequently attributed to somatic memory. In this study, we compared hematopoietic differentiation capacity of 35 human iPSC lines derived from four different tissues and four embryonic stem cell lines. The analysis revealed that hematopoietic commitment capacity (PSCs to hematopoietic precursors) is correlated with the expression level of the IGF2 gene independent of the iPSC origins. more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
29 Samples

Download data: BW, TXT

Series

Accession:: GSE74967

ID:: 200074967

PubMed Similar studies SRA Run Selector

Select item 20007363018.

Reprogramming-associated aberrant DNA methylation determines hematopoietic differentiation capacity of human induced pluripotent stem cells [iPSCs_methylation]

(Submitter supplied) The variation among induced pluripotent stem cells (iPSCs) in their differentiation capacity to specific lineages is frequently attributed to somatic memory. In this study, we compared hematopoietic differentiation capacity of 35 human iPSC lines derived from four different tissues and four embryonic stem cell lines. The analysis revealed that hematopoietic commitment capacity (PSCs to hematopoietic precursors) is correlated with the expression level of the IGF2 gene independent of the iPSC origins. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
9 Samples

Download data: TXT

Series

Accession:: GSE73630

ID:: 200073630

Select item 20007362919.

Reprogramming-associated aberrant DNA methylation determines hematopoietic differentiation capacity of human induced pluripotent stem cells [parental_lines_expression]

(Submitter supplied) The variation among induced pluripotent stem cells (iPSCs) in their differentiation capacity to specific lineages is frequently attributed to somatic memory. In this study, we compared hematopoietic differentiation capacity of 35 human iPSC lines derived from four different tissues and four embryonic stem cell lines. The analysis revealed that hematopoietic commitment capacity (PSCs to hematopoietic precursors) is correlated with the expression level of the IGF2 gene independent of the iPSC origins. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
5 Samples

Download data: TXT

Series

Accession:: GSE73629

ID:: 200073629

Select item 20006092420.

Reprogramming-associated aberrant DNA methylation determines hematopoietic differentiation capacity of human induced pluripotent stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL13534 GPL14550
181 Samples

Download data: TXT

Series

Accession:: GSE60924

ID:: 200060924

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