Similar studies for GEO DataSets (Select 200031625) - GEO DataSets

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Items: 20

Select item 2000316251.

Gene Expression Patterns that Predict Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer Cell Lines and Human Lung Tumors

(Submitter supplied) Global gene expression data were generated from cultured non small cell lung cancer cell lines (NSCLC), normalized using MAS 5.0, filtered and used to predict response of cells to EGFR inhibition

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
48 Samples

Download data: CEL

Series

Accession:: GSE31625

ID:: 200031625

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000636852.

Clinical Utility of Patient Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma

(Submitter supplied) PURPOSE: Although epidermal growth factor receptor (EGFR) mutated adenocarcinomas initially have very high response rates to EGFR tyrosine kinase inhibitors (TKIs), most atients eventually develop resistance. Patient derived xenografts (PDXs) are considered preferred preclinical models to study the biology of patient tumors. EGFR-mutant PDX models may be valuable tools to study the biology of these tumors and to elucidate mechanisms of resistance to EGFR-targeted therapies. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platform:: GPL14951
25 Samples

Download data: TXT

Series

Accession:: GSE63685

ID:: 200063685

Select item 2000043423.

Gefitinib sensitivity in NSCLC cell lines

(Submitter supplied) Eleven NSCLC cell lines with widely divergent gefitinib sensitivities were compared using gene expression. Genes associated with gefitinib response were used to classify additional NSCLC lines with unknown gefitnib sensitivity. A subset of the test set data was tested for gefitinib sensitivity, and results correlated strongly with the gene expression-based predictions All eleven training set lines, and seven test set lines had both HGU133A and B chips done, while other test set lines had only HGU133As. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS2297 GDS2298
Platforms:: GPL97 GPL96
63 Samples

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Series

Accession:: GSE4342

ID:: 200004342

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 22984.

Gefitinib effect on various non-small cell lung cancer cell lines (HG-U133B)

Analysis of baseline non-small cell lung cancer (NSCLC) cell lines with a broad range of sensitivity to the anticancer drug gefitinib. Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). Results used to define a gene expression signature of gefitinib sensitivity.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 18 cell line, 3 other, 2 protocol sets

Platform:: GPL97
Series:: GSE4342
18 Samples

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DataSet

Accession:: GDS2298

ID:: 2298

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 22975.

Gefitinib effect on various non-small cell lung cancer cell lines (HG-U133A)

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 41 cell line, 4 other, 2 protocol sets

Platform:: GPL96
Series:: GSE4342
45 Samples

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DataSet

Accession:: GDS2297

ID:: 2297

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000173736.

Expression data from EGFR mutant transgenic mice

(Submitter supplied) We performed mRNA expression profiling of lung tumors from C/L858R, C/T790M, and C/L+T mice and from corresponding normal lung tissue.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
24 Samples

Download data: CEL

Series

Accession:: GSE17373

ID:: 200017373

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000330727.

An epithelial-mesenchymal transition (EMT) gene signature predicts resistance to erlotinib and PI3K pathway inhibitors and identifies Axl as a novel EMT marker in non-small cell lung cancer.

(Submitter supplied) Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, its potential to predict response to other targeted drugs or chemotherapy has not been well characterized. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
131 Samples

Download data: CEL

Series

Accession:: GSE33072

ID:: 200033072

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000329898.

Expression profiling of lung cancer cell lines (UTSW Lung Panel V2)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13376
69 Samples

Download data: TXT

Series

Accession:: GSE32989

ID:: 200032989

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000320369.

Expression profiling of lung cancer cell lines

(Submitter supplied) Purpose: To determine the 8-week disease control rate (DCR) of sorafenib monotherapy in patients with advanced non-small-cell lung cancer (NSCLC) in the BATTLE trial. Methods: Patients with pre-treated NSCLC, ECOG performance status (PS) 0-2, consented to biopsies to test for biomarker assessment. Sorafenib was given at 400 mg orally twice daily until tumor progression or an unacceptable toxicity. Tumor evaluations were performed at baseline and every 8 weeks. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL10558 GPL6884
222 Samples

Download data: TXT

Series

Accession:: GSE32036

ID:: 200032036

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009330010.

Gene expression-signatures for non-small cell lung cancer patients with different EGFR muational status.

(Submitter supplied) To identify a plasma miRNA panel that could help to separate NSCLC patients with EGFR sensitive mutations and wild-type EGFR, plasma samples of 3 EGFR19DEL, 3 EGFRp.L858R, and 3 EGFRWT patients with NSCLC and 4 HCs were selected for Agilent miRNA microarray analysis to detect differences in the expression levels of circulating miRNAs (n = 2,568) between the above cohorts.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL21576
13 Samples

Download data: TXT, XLS

Series

Accession:: GSE93300

ID:: 200093300

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007457511.

Microarray expression profile of long noncoding RNAs in EGFR-TKI resistance of lung adenocarcinoma

(Submitter supplied) Lung adenocarcinoma cells harboring epidermal growth factor receptor (EGFR) mutations are sensitive to EGFR tyrosine kinase inhibitors (TKIs). Prolonged cancer treatment will induce the development of acquired resistance to EGFR TKI. To gain insight into the molecular mechanisms of EGFR-TKIs resistance, we generate EGFR-TKI-resistant HCC827-8-1 cells to be analyzed by microarray with their parental HCC827cells.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL21096
6 Samples

Download data: TXT

Series

Accession:: GSE74575

ID:: 200074575

Select item 20010449412.

Gene Expression Regulation by Lung Cancer Oncogenes

(Submitter supplied) To characterize gene expression changes induced by oncogenes implicated in human lung adenocarcinoma, we analyzed the whole transcriptome of NIH3T3 cells expressing mutant EGFR (exon 19 deletion) or wild-type EGFR. Expression levels of several genes from this list were validated by quantitative RT-PCR using the same RNA samples.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
4 Samples

Download data: TXT

Series

Accession:: GSE104494

ID:: 200104494

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004913513.

Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib

(Submitter supplied) Elevated expression and activity of the epidermal growth factor receptor (EGFR) is associated with development and progression of head and neck cancer (HNC) and a poor prognosis. Clinical trials with EGFR tyrosine kinase inhibitors (TKIs; eg. erlotinib) have been disappointing in HNC. To investigate the mechanisms mediating resistance to these agents, we developed a HNC cell line (HN5-ER) with acquired erlotinib resistance. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
6 Samples

Download data: TXT

Series

Accession:: GSE49135

ID:: 200049135

Select item 20014737714.

Genomic CpG methylation and TKI-response of the patient with advanced stage lung adenocarcinoma

(Submitter supplied) The DNA methylation signature involved 87 differentially methylated regions (DMR) that distinguished patients’ response to EGFR-TKIs. The methylation level of HOXB9 (cg13643585) which was negatively correlated with gene expression and annotated as function of transcription factor displayed 88% and 92% of sensitivity with respect to objective response rate (ORR, OR=9.25, p=0.0002) and disease control rate (DCR, OR=6.64, p=0.0009), respectively. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
79 Samples

Download data: CSV

Series

Accession:: GSE147377

ID:: 200147377

PubMed Full text in PMC Similar studies

Select item 20003121015.

Gene expression data for pathological stage I-II lung adenocarcinomas

(Submitter supplied) Identification of genes up-regulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. To elucidate molecular characteristics of lung adenocarcinomas (ADCs) with ALK mutations and those without EGFR, KRAS and ALK mutations, 226 primary lung ADCs of pathological stage I-II, examined for the status of EGFR, KRAS and ALK mutations, were subjected to genome-wide expression profiling, and genes up-regulated in lung ADCs with ALK mutations and those without EGFR, KRAS and ALK mutations were identified. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
246 Samples

Download data: CEL

Series

Accession:: GSE31210

ID:: 200031210

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005779716.

Expression data from the subclones of Lewis Lung Carcinoma (LLC) cells

(Submitter supplied) Medium conditioned by LLC cells stimulates thermogenic gene expression when added onto primary adipocytes. We generated single cell colonies from parental LLC cells. Media conditioned by the subclones stimulated thermogenic gene expression in primary adipocytes at varying degrees. Subclones 2, 3, 6 and 28 produce significantly larger amount of thermogenic activity than the subclones 18, 19, 23 and 24. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
23 Samples

Download data: CEL, CHP

Series

Accession:: GSE57797

ID:: 200057797

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20016561117.

Translational application of pharmacogenomics for refractory lung cancer

(Submitter supplied) Patient-derived cells (PDC) recapitulate the characteristics of lung cancer and its therapeutic response. We collected cancer cells of patients to receive various chemotherapy and performed integrative analysis for pharmachogenomics.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
102 Samples

Download data: TXT

Series

Accession:: GSE165611

ID:: 200165611

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20001612018.

Gene profiling, mutations and expression of epidermal growth factor receptor in androgen-dependent prostate cancer

(Submitter supplied) We analyzed mutations in Epidermal Growth Factor Receptor (EGFR) Tyrosine kinase (TK) domain, EGFR expression and gene profiling in prostate carcinoma (PC) in order to find out molecular prognostic markers and supply a proof for EGFR targeted therapies. 100 glyofixx-fixed, paraffin-embedded PC specimens were recovered after radical prostatectomy from locally advanced PC patients. Exons from 18 to 21 of EGFR TK domain were amplified and sequenced. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL887
65 Samples

Download data: TXT

Series

Accession:: GSE16120

ID:: 200016120

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001420619.

Analysis of ETS gene expression patterns uncovers novel ETS mediated gene silencing pathways in prostate cancers

(Submitter supplied) Deregulated expression of ETS transcription factors with oncogenic and tumor suppressor function occurs frequently in prostate cancer leading to profound alterations of the cancer transcriptome. By integrating genomic and functional studies we identified key targets of the aberrantly expressed ETS factors, ERG and ESE3. Altered expression of ETS factors led to the induction of the polycomb group protein EZH2 and silencing of the tumor suppressor Nkx3.1. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL887
67 Samples

Download data: TXT

Series

Accession:: GSE14206

ID:: 200014206

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000959920.

Coordinated over-expression of genes in the EGFR pathway predicts sensitivity to EGFR inhibition in pancreatic cancer

(Submitter supplied) Tumors from pancreatic cancer specimens obtained at surgery were used for efficacy testing and biologic analysis Keywords: Pharmacogenetics

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
36 Samples

Download data: CEL

Series

Accession:: GSE9599

ID:: 200009599

PubMed Full text in PMC Similar studies Analyze with GEO2R

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