GEO DataSets

(Submitter supplied) New experiences can trigger changes in gene expression in the brain. To understand this phenomenon better, we studied zebra finches hearing playbacks of birdsong. Earlier research had shown that initial playbacks of a novel song transiently increase the ZENK (ZIF-268, EGR1, NGFIA, KROX-24) mRNA in the auditory forebrain, but the response selectively habituates after repetition of the stimulus. Here, using DNA microarray analysis, we show that novel song exposure induces rapid changes in thousands of RNAs, with even more RNAs decreasing than increasing. more...

Organism:

Taeniopygia guttata

Type:

Expression profiling by array

Platform:

GPL9554

18 Samples

Download data: GPR

(Submitter supplied) We queried a songbird brain to discover behaviorally regulated transcriptional mechanisms relevant for speech behavior. About 10% of zebra finch genes showed regulation during singing, and most were brain-region specific. We propose that the brain-regional diversity of the singing-regulated gene networks is derived both from differential combinatorial binding of transcription factors and the epigenetic state of these genes before singing begins. more...

Organism:

Taeniopygia guttata

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL19155

8 Samples

Download data: BW, TXT

(Submitter supplied) Studies of transcriptional networks in multi-cellular organisms usually focus on isolated cells and typically assume that the discovered gene networks represent those present in connected cells within a complex organ like the brain. However, similar cell types connected in diverse anatomical networks could differentially influence transcriptional networks. Here, we used laser capture microdissection, expression arrays, genome mapping, and computational inference to explore behaviorally regulated gene networks in the brains of awake, behaving songbirds producing a skilled motor behavior, singing. more...

Organism:

Taeniopygia guttata

Type:

Expression profiling by array

Platform:

GPL9856

170 Samples

Download data: TXT

(Submitter supplied) Like human speech, birdsong is a complex vocal behavior that is acquired by sensorimotor learning based on coordination of auditory input and vocal output to mimic memorized tutor song. Here we investigate neural circuits for vocal learning and production in deafened songbirds to elucidate how sensory-input regulate genetic and epigenetic property of vocal development and its associated gene expression dynamics. more...

Organism:

Taeniopygia guttata

Type:

Expression profiling by array

Platform:

GPL18442

36 Samples

Download data: TXT

(Submitter supplied) Songbirds possess one of the most accessible neural systems for the study of brain mechanisms of behavior. However, neuroethological studies in songbirds have been limited by the lack of high-throughput molecular resources and gene manipulation tools. To overcome this limitation, here we generated a resource of full-length cDNAs for gene expression analyses and gene manipulation in songbirds. We constructed 21 regular, normalized, and subtracted full-length cDNA libraries from brains of songbirds in 57 behavioral and developmental conditions in an attempt to clone as much of the brain transcriptome as possible. more...

Organism:

Taeniopygia guttata

Type:

Expression profiling by array

Platform:

GPL3621

14 Samples

Download data

(Submitter supplied) All of the details of the manufacture protocol can be found in Wada et al. 2006.

Organism:

Taeniopygia guttata

1 Series

14 Samples

Download data