GEO DataSets

(Submitter supplied) In order to clarify the molecular mechanism involved in renal carcinogenesis, and identify molecular targets for diagnosis and treatment, we analyzed genome-wide gene expression profiles of 15 surgical specimens of clear cell renal cell carcinoma (RCC), compared to normal renal cortex, using a combination of laser microbeam microdissection (LMM) with a cDNA microarray representing 27,648 genes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4747

15 Samples

Download data: TXT

(Submitter supplied) In order to address the progression, metastasis, and clinical heterogeneity of renal cell cancer (RCC), transcriptional profiling with oligonucleotide microarrays (22,283 genes) was done on 49 RCC tumors, 20 non-RCC renal tumors, and 23 normal kidney samples. Samples were clustered based on gene expression profiles and specific gene sets for each renal tumor type were identified. Gene expression was correlated to disease progression and a metastasis gene signature was derived. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

92 Samples

Download data: CEL, TXT

(Submitter supplied) The clear cell subtype of renal cell carcinoma (RCC) is the most lethal and prevalent cancer of the urinary system. To investigate the molecular changes associated with malignant transformation in clear cell RCC, the gene expression profiles of matched samples of tumor and adjacent non-neoplastic tissue were obtained from 6 patients. A custom-built cDNA microarray platform was used, comprising 2,292 probes that map to exons of genes and 822 probes for noncoding RNAs mapping to intronic regions. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3985

48 Samples

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(Submitter supplied) Myc oncogenic signature in Papillary type 2b Keywords: Gene Expression experiment

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4866

47 Samples

Download data: CEL

(Submitter supplied) To characterize the molecular features of clinical (Hormone-Refractory Prostate Cancers) HRPCs, we generated the precise gene-expression profiles of 25 clinical HRPCs and 10 hormone-sensitive prostate cancers (HSPCs) by genome-wide cDNA microarrays combining with laser microbeam microdisection. Keywords: disease status analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4747

35 Samples

Download data: TXT

(Submitter supplied) Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney. Currently, there are no biomarkers for the diagnostic, prognostic, or predictive applications in RCC. MicroRNAs (miRNAs) are short non protein-coding RNAs that negatively regulate gene expression and have been shown to be involved in cancer. We analyzed a total of 70 matched pairs of clear cell RCC (ccRCC) and normal kidney tissues from the same patients by microarray analysis and validated our results by quantitative real time PCR. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL10415

20 Samples

Download data: TXT

(Submitter supplied) Tumor tissue heterogeneity is a well known feature of several solid tumors. Neuroblastic Tumors (NTs) is a group of paediatric cancers with a great tissue heterogeneity. Most of NTs are composed of undifferentiated, poorly differentiated or differentiating neuroblastic (Nb) cells with very few or absent Schwannian stromal (SS) cells: these tumors are grouped as Neuroblastoma (Schwannian stroma-poor). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

28 Samples

Download data: CEL

(Submitter supplied) Identification of genes regulated by the transcription factor HNF4a2 Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

8 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) Analysis of gene expression in human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X, which were introduced by FRT/FLP recombination. The analysis was performed 24 hours following 1µg/ml tetracycline treatment to induce the expression of the genes. Results identify HNF4a regulated genes in kidney cells being several of these genes deregulated in renal cell carcinoma. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

8 Samples

Download data

(Submitter supplied) Renal cell carcinoma is the most common neoplasm of the adult kidney. A few subtypes of RCC include papillary RCC (pRCC), chromophobe RCC (chRCC) and the benign oncocytoma tumor. In some cases, distinguishing between the RCC subyptes is difficult. We performed a mircroRNA (miRNA) microarray to determine differential miRNA expression between pRCC, chRCC, and oncocytoma.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL10415

15 Samples

Download data: TXT

(Submitter supplied) Our goal was to identify gene expression features, using comprehensive gene expression profiling, that correlate with survival in conventional renal cell carcinomas (cRCCs). We profiled 177 cRCCs using high-density cDNA microarrays. Unsupervised hierarchical clustering analysis segregated cRCC into five gene expression subgroups. Expression subgroup was correlated with survival in long-term follow-up and was independent of grade, stage, and performance status. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

10 related Platforms

177 Samples

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(Submitter supplied) to see if CCPRCC has a distinct miRNA profile from CCRCC and PRCC

Organism:

Homo sapiens; synthetic construct

Type:

Non-coding RNA profiling by array

Platform:

GPL14613

24 Samples

Download data: CEL

(Submitter supplied) In order to clarify the downstream target genes of SPAG4, we performed knockdown of SPAG4 using siRNA both under normoxia and hypoxia.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data: CEL

(Submitter supplied) To identify novel molecular targets for triple negative breast cancer (TNBC), we have employed whole genome microarray expression profiling. We purified 30 surgically resected breast cancer tissue diagnosed triple negative by means of immunohistochemical staining and 13 normal mammary ductal cells with lasermicrobeam microdissection system (PALM MicroBeam, Carl Zeiss MicroImaging Co., Ltd), performed whole human genome microarray, and compared gene expression levels of TNBC, normal mammary ductal cells, and normal vital organs to develop molecular targets with a minimum risk.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

47 Samples

Download data: TXT

(Submitter supplied) Each total RNA sample is hybridized to two different arrays: Affymetrix U133A (GPL96) and U133B (GPL97). For most of the normal tissue samples there is a renal clear cell carcinoma sample from the same patient. There is no matching tumor sample for normal sample N1. For most of the renal clear cell carcinoma samples there is a corresponding adjacent normal tissue sample from the same patient. There are no matching normal tissue samples for C011 or C032. Keywords = kidney Keywords = renal Keywords = RCC Keywords = carcinoma Keywords = cancer Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS505 GDS507

Platforms:

GPL96 GPL97

34 Samples

Download data: CEL

Investigation into mechanisms of renal clear cell carcinogenesis (RCC). Comparison of renal clear cell tumor tissue and adjacent normal tissue isolated from the same surgical samples.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 10 individual sets

Platform:

GPL97

Series:

GSE781

17 Samples

Download data: CEL

Investigation into mechanisms of renal clear cell carcinogenesis (RCC). Comparison of renal clear cell tumor tissue and adjacent normal tissue isolated from the same surgical samples.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 10 individual sets

Platform:

GPL96

Series:

GSE781

17 Samples

Download data: CEL

(Submitter supplied) The antiproliferative, antiviral, and immunomodulatory properties of interferons (IFNs) have led to its therapeutic implementation. IFNs effects are mediated by a complex network of signal transducers, culminating in IFN-stimulated gene (ISG) induction. This complexity leads to diverse clinical responses to IFN, from no response to complete regression of disease. Elucidation of ISG induction patterns is, therefore, essential to understand and maximize its therapeutic potential. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8281

12 Samples

Download data: GPR

(Submitter supplied) Array contains 810 unique putative ISGs, 85 housekeeping genes, and 4 bacterial control genes. Protocol: ISG cDNA microarray was generated from a list of ISGs compiled from previous array experiments in our laboratory and others. Housekeeping genes and bacterial control genes were also included for standardization or normalization purposes. cDNA for genes was obtained, and arrays were printed as previously reported in Frevel MA, Bakheet T, Silva AM, Hissong JG, Khabar KS, Williams BR. more...

Organism:

Homo sapiens

2 Series

7 Samples

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(Submitter supplied) Array contains 758 unique putative ISGs, 85 housekeeping genes, and 4 bacterial control genes. Protocol: ISG cDNA microarray was generated from a list of ISGs compiled from previous array experiments in our laboratory and others. Housekeeping genes and bacterial control genes were also included for standardization or normalization purposes. cDNA for genes was obtained, and arrays were printed as previously reported in Frevel MA, Bakheet T, Silva AM, Hissong JG, Khabar KS, Williams BR. more...

Organism:

Homo sapiens

2 Series

12 Samples

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