Similar studies for GEO DataSets (Select 200046014) - GEO DataSets

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Items: 20

Select item 2000460141.

Histone modification and TF ChIP-Seq for glioblastoma cell lines and neural stem cells

(Submitter supplied) Glioblastoma (GBM) is thought to be driven by a sub-population of cancer stem cells (CSCs) that self-renew and recapitulate tumor heterogeneity, yet remain poorly understood. Here we present a comparative epigenomic analysis of GBM CSCs that reveals widespread activation of genes normally held in check by Polycomb repressors. These activated targets include a large set of developmental transcription factors (TFs) whose coordinated activation is unique to the CSCs. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9115 GPL11154
40 Samples

Download data: WIG

Series

Accession:: GSE46014

ID:: 200046014

PubMed Full text in PMC Similar studies

Select item 2000460162.

Epigenomic profiling of glioblastoma stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by array

4 related Platforms
58 Samples

Download data: CEL, WIG

Series

Accession:: GSE46016

ID:: 200046016

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000460153.

DNA methylation profiling of glioblastoma cancer stem cells

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
6 Samples

Download data: TXT

Series

Accession:: GSE46015

ID:: 200046015

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000458994.

Expression profiling of glioblastoma cancer stem cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE45899

ID:: 200045899

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000250125.

WNT pathway activation promotes phenotypic reprogramming of glioblastoma derived cells in zebrafish nervous system microenvironment

(Submitter supplied) phenotypic reprogramming ability of teh zebtafish brain microenviroment on GBM derived cells controlled by the activation of endogenous Wnt pathway

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE25012

ID:: 200025012

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000905476.

Identifying ASCL1-mediated chromatin changes in primary GBM stem cell cultures [ATAC-seq]

(Submitter supplied) ASCL1 mediates neuronal differentiation of GBM stem cell (GSC) cultures. We sought to identify chromatin changes upon induced ASCL1 expression in primary human GSC cultures. In this dataset, we include ATAC-seq data obtained from GSC cultures harbouring a CRISPR-deletion of ASCL1. We assessed differential ASCL1 binding between control and GSC cultures induced to overexpress ASCL1 after 14 days of doxycycline treatment.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: NARROWPEAK

Series

Accession:: GSE90547

ID:: 200090547

PubMed Similar studies SRA Run Selector

Select item 2000876197.

Temporal gene expression of human-fetal and glioblastoma stem cell cultures under directed differentiation conditions

(Submitter supplied) Primary glioblastoma (GBM) cultures vary with respect to differentiation competency. We sought to identify putative transcription factors necessary for the differentiation of GBM cultures. In this dataset, we include expression data obtained from 2 human-fetal neural stem cell (HF-NS) cultures and 2 GBM stem cell (GSC) cultures. We assessed changes in gene expression from 3 timepoints during an in vitro differentiation protocol.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5188
12 Samples

Download data: CEL

Series

Accession:: GSE87619

ID:: 200087619

Select item 2000876188.

Identifying ASCL1 target genes in primary GBM stem cell cultures [ChIP-seq]

(Submitter supplied) ASCL1 mediates neuronal differentiation of GBM stem cell (GSC) cultures. We sought to identify genomic targets of ASCL1 in primary human GSC cultures. In this dataset, we include ChIP-seq data obtained from GSC cultures harbouring a CRISPR-deletion of ASCL1. We assessed differential ASCL1 binding between control and GSC cultures induced to overexpress ASCL1 after 18 hours of doxycycline treatment.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
8 Samples

Download data: NARROWPEAK

Series

Accession:: GSE87618

ID:: 200087618

PubMed Similar studies SRA Run Selector

Select item 2000876179.

Identifying ASCL1 target genes in primary GBM stem cell cultures [RNA-seq]

(Submitter supplied) ASCL1 mediates neuronal differentiation of GBM stem cell (GSC) cultures. We sought to identify targets of ASCL1 in primary human GSC cultures. In this dataset, we include RNA-seq data obtained from GSC cultures harbouring a CRISPR-deletion of ASCL1. We assessed differential gene expression between control and GSC cultures induced to overexpress ASCL1 after 7 days of doxycycline treatment.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE87617

ID:: 200087617

Select item 20008761510.

ASCL1 mediates neuronal differentiation of primary GBM stem cell cultures upon Notch signalling blockade [RNA-seq]

(Submitter supplied) ASCL1 mediates neuronal differentiation of GBM stem cell (GSC) cultures upon Notch signalling inhibition. We sought to identify gene expression changes that were specific to ASCL1 function. In this dataset, we include RNA-seq data obtained from GSC cultures harbouring wildtype or CRISPR-deletion of ASCL1. We assessed differential gene expression between wildtype and ASCL1-knockout after treatment with gamma-secretase inhibitor for 7 days.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE87615

ID:: 200087615

Select item 20001815011.

DZNep-treated glioblastoma multiforme cancer stem cells

(Submitter supplied) Overexpression of the Polycomb group protein Enhancer of Zeste Homolog 2 (EZH2) occurs in diverse malignancies, including prostate cancer, breast cancer, and glioblastoma multiforme (GBM) (1). Based on its ability to modulate transcription of key genes implicated in cell cycle control, DNA repair and cell differentiation, EZH2 is believed to play a crucial role in tissue-specific stem cell maintenance and tumor development. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE18150

ID:: 200018150

Select item 20011351212.

A HIF-1α/Wnt signaling-dependent control of gene transcription regulates neuronal differentiation of glioblastoma stem cells

(Submitter supplied) HIF-1α plays a crucial role in sustaining glioblastoma (GBM) cell growth and the maintenance of their undifferentiated phenotype. However, HIF-1α has been suggested to interplay with Wnt signaling components, thus activating a neuronal differentiation process in both GBM and normal brain. Here, we show that a β-catenin/TCF1/HIF-1α complex directly controls the transcription of neuronal differentiation genes in hypoxia. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23159
8 Samples

Download data: CEL, TXT

Series

Accession:: GSE113512

ID:: 200113512

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012684013.

RNA-sequencing of Wnt-dependent and Wnt-independent of Glioblastoma stem cell cultures

(Submitter supplied) Four Wnt-dependent and four Wnt-independent GSC cultures were grown in stem cell media and RNA expression between the two subsets evaluated

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
8 Samples

Download data: CSV, TXT

Series

Accession:: GSE126840

ID:: 200126840

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20009833014.

Changes in chromatin state reveal a central role for the transcription factor ARNT2, in the control of glioblastoma stem cell tumorigenicity

(Submitter supplied) Although a growing body of evidence indicates that the phenotypic plasticity exhibited by glioblastoma cells plays a central role in tumor development and post-therapy recurrence, the master drivers of their aggressiveness remain elusive. Here we mapped the changes in the transcriptionally permissive (H3K4me3) and repressive (H3K27me3) epigenetic histone marks accompanying the repression of glioblastoma stem cells (GSC) tumorigenicity. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: BED

Series

Accession:: GSE98330

ID:: 200098330

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005479215.

Epigenomic profiling of stemness, differentiation and primary tissues in human glioblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL11154
49 Samples

Download data: BED, BIGWIG, BW

Series

Accession:: GSE54792

ID:: 200054792

PubMed Full text in PMC Similar studies

Select item 20005479116.

Reconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells: RNA-seq

(Submitter supplied) Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on a cellular hierarchy reminiscent of normal development but superimposed on underlying genetic aberrations. In glioblastoma (GBM), a subset of stem-like tumor- propagating cells (TPCs) appears to drive tumor progression and underlie therapeutic resistance, yet remain poorly understood. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL16791
23 Samples

Download data: BW, TXT

Series

Accession:: GSE54791

ID:: 200054791

PubMed Full text in PMC Similar studies

Select item 20005404717.

Reconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells: ChIP-seq

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL11154
26 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE54047

ID:: 200054047

PubMed Full text in PMC Similar studies

Select item 20015240118.

ASCL1 ChIP-seq of patient-derived-xenograft (PDX) GBM lines and RNA-seq of mouse glioma tumors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11002 GPL10999
14 Samples

Download data: BW

Series

Accession:: GSE152401

ID:: 200152401

PubMed Full text in PMC Similar studies

Select item 20015240019.

RNA-seq of mouse glioma tumors with or without ASCL1

(Submitter supplied) Tamoxifen was administered to Glast-CreER;Nf1-flox/flox;Tp53-flox/flox or Glast-CreER;Ascl1-flox/flox;Nf1-flox/flox;Tp53-flox/flox at E14.5 to induce tumors in the brain