Similar studies for GEO DataSets (Select 200047352) - GEO DataSets

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Items: 20

Select item 2000473521.

Identification of metastasis associated genes in clear cell renal cell carcinoma

(Submitter supplied) This study investigates the genes that promote clear cell renal cell carcimoma (ccRCC) metastasis using 4 primary metastatic and 5 non-metastatic tumor samples. U133 plus 2.0 array was used to identify the diffrently expressed genes between the primary metastatic and non metastatic ccRCC samples

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
9 Samples

Download data: CEL

Series

Accession:: GSE47352

ID:: 200047352

Select item 2000889482.

LncRNA from metastatic clear cell renal cell carcinoma (ccRCC) compared with non-metastatic clear cell renal carcinoma

(Submitter supplied) A total of 3 metastatic and 3 non-metastatic ccRCC tissues were collected from patients. These tissues were flash frozen in liquid nitrogen immediately after surgery and subsequently stored at -80℃. All the resected nodules or metastatic masses were identified as renal tumor by pathologic examination. No patients received anticancer treatments before surgery in this study. We analyzed gene expression microarray data from our gene chip with 3 metastatic ccRCC tissues compared with 3 non-metastatic ccRCC tissues.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL16238
6 Samples

Download data: CEL

Series

Accession:: GSE88948

ID:: 200088948

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000662723.

Genome-wide analysis of gene expression patterns in human kidney cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
54 Samples

Download data: CEL

Series

Accession:: GSE66272

ID:: 200066272

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000662714.

Genome-wide analysis of gene expression patterns in human kidney cancer [patients with metastasis]

(Submitter supplied) To investigate the mechanisms of kidney tumor progression and metastasis, we performed expression profiling of human kidney cancer and benign tissues.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
26 Samples

Download data: CEL

Series

Accession:: GSE66271

ID:: 200066271

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000662705.

Genome-wide analysis of gene expression patterns in human kidney cancer [patients without metastasis]

(Submitter supplied) To investigate the mechanisms of ccRCC progression and metastasis, we performed expression profiling of human kidney cancer and benign tissues.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
28 Samples

Download data: CEL

Series

Accession:: GSE66270

ID:: 200066270

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000110726.

Global analysis of metastasis-associated gene expression in the primary cultures from clinical specimens of ccRCC

(Submitter supplied) Metastatic clear cell renal cell carcinoma (ccRCC) has a poor prognosis and unpredictable course and there are no molecular markers that reliably predict ccRCC metastasis. In this study, specimens from 84 patients with ccRCC were directly cultured in vitro. The primary cultures from 38 of 94 specimens contained more than 90% tumor cells at 4th passages. After identified by immunostaining, the primary cultures of metastatic- and nonmetastatic ccRCC specimens from the age-, gender-matched patients were subjected to cDNA microrray assays. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6259
12 Samples

Download data: TXT

Series

Accession:: GSE11072

ID:: 200011072

Select item 2000769487.

Expression data from Chinese renal cell carcinoma cells with FSTL1 knocked down

(Submitter supplied) Clear cell renal cell carcinoma (ccRCC), the major histotype of cancer derived from kidney, is lack of robust prognostic and/or predictive biomarker and powerful therapeutic target. We previously identified that follistatin-like protein 1 (FSTL1) was significantly down-regulated in ccRCC at the transcription level. In the present study, we characterized, for the first time, that FSTL1 immunostaining was selectively positive in the cytoplasm of distal convoluted tubules. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
3 Samples

Download data: CEL

Series

Accession:: GSE76948

ID:: 200076948

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000551388.

Expression data from ccRCC specimens

(Submitter supplied) To identify a therapeutic candidate target molecule for ccRCC, we analyzed the microRNA (miRNA) expression signatures in ccRCC clinical specimens.

Organism:: Homo sapiens; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL14613
25 Samples

Download data: CEL

Series

Accession:: GSE55138

ID:: 200055138

Select item 2000225419.

Expression data from pulmonary metastases and primary tumors of clear-cell renal cell carcinoma (ccRCC) with different disease-free survivals

(Submitter supplied) The understanding of metastatic spread is limited and molecular mechanisms causing particular characteristics of metastasis are largely unknown. This comprises the extremely varying dormancy periods of tumor cells in the secondary organ after metastatic spread, represented by the disease-free survival (DFS) of the patients, or differing numbers of metastases in different patients. Knowing the molecular fundamentals of these phenomena would support the individual prediction of patients´ outcome and facilitate the decision for an appropriate monitoring and therapy regime. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
68 Samples

Download data: CEL

Series

Accession:: GSE22541

ID:: 200022541

Select item 20003395410.

Assessing the clear cell Renal Cell Carcinoma (ccRCC) DNA-methylome by MethylCapSeq

(Submitter supplied) MethylCap-Seq experiments of 4 ccRCC cell lines (SKRC1, SKRC10, SKRC52, SKRC59) and one "normal" kidney cell line (HK2) were performed, and used, in combination with DAC/TSA re-expression data, to mine the ccRCC specific cancer methylome. Identified candidate DNA-methylation markers were evaluated by MSP in two independent series, yielding 4 validated markers (GREM1, NEURL, LAD1, NEFH) of which promoter methylation was highly predictive of survival.

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL10999
5 Samples

Download data: BOWTIE

Series

Accession:: GSE33954

ID:: 200033954

PubMed Similar studies SRA Run Selector

Select item 20014083511.

MiR-765 functions as a tumour suppressor and eliminates lipids in clear cell renal cell carcinoma by downregulating PLP2

(Submitter supplied) MicroRNAs (miRNAs) expression profiles are widely investigated in the major cancers, but their expression in patients plasmas of cancers have not yet to be fully elucidated. We investigated expression profiles of miRNAs in patients preoperative/postoperative plasmas of clear cell renal cell carcinomas (ccRCCs) by using a miRNAs microarray platform which covers a total of 1,523 human miRNAs.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL16770
10 Samples

Download data: TXT, XLSX

Series

Accession:: GSE140835

ID:: 200140835

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005476412.

Analysis of transcriptional targets of KLF6 in HCC through gene expression profiling and ChIP-sequencing

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE54764

ID:: 200054764

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005476313.

DNA binding sites of KLF6 in murine HCC

(Submitter supplied) We sequenced DNA isolated from performing ChIP of full-length KLF6 and an Input sample in an HCC cell line. The goal is to determine KLF6 binding sites in a mouse-derived HCC cell line.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: TXT

Series

Accession:: GSE54763

ID:: 200054763

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005476214.

Gene expression changes occuring as a result of KLF6 knockdown in murine HCC

(Submitter supplied) We performed whole genome expression profiling using a murine HCC cell line that was either infected with a virus containing shRNA targeting KLF6 or GFP. 3 sets of infections were performed for both shGFP and shKLF6 samples. RNA was isolated from these samples and subsequently analyzed.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE54762

ID:: 200054762

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005475715.

Determination of gene expression changes in HCC cells selected for migration ability.

(Submitter supplied) We determined whole genome expression changes in 2 migratory cell lines that were derived from a parent HCC cell line.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE54757

ID:: 200054757

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010671916.

Decreased TGFBR3/Betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-b-dependent and independent mechanisms

(Submitter supplied) It is unclear how the loss of TGF-b signaling components affects metastatic abilities in clear cell renal cell carcinoma (ccRCC). In this study, we identified that low TGFBR3 expression in ccRCC cells enhanced primary tumor formation and lung metastasis. In the presence of TGFBR3, TGF-b2 decreased the aldehyde dehydrogenase (ALDH)-positive ccRCC cell population, in which renal cancer-initiating cells are enriched. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17303
4 Samples

Download data: XLSX

Series

Accession:: GSE106719

ID:: 200106719

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008525817.

Differential gene expression profiling of matched primary renal cell carcinoma and metastases reveals upregulation of extracellular matrix genes

(Submitter supplied) It is unknown if gene expression profiles from primary RCC tumors differ from patient-matched metastatic tumors. Thus, we sought to identify differentially expressed genes between patient-matched primary and metastatic RCC tumors in order to understand the molecular mechanisms underlying the development of RCC metastases.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
31 Samples

Download data: CEL

Series

Accession:: GSE85258

ID:: 200085258

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006674118.

RNA-sequencing in OS-RC-2 cells under the knockdown of Arkadia or ESRP2

(Submitter supplied) Tumor-specific alternative splicing is implicated in the progression of cancer, including clear cell renal cell carcinoma (ccRCC). Using ccRCC RNA-sequencing data from The Cancer Genome Atlas, we found that epithelial splicing regulatory protein 2 (ESRP2), one of the key regulators of alternative splicing in epithelial cells, is expressed in ccRCC. ESRP2 mRNA expression did not correlate with the overall survival rate of ccRCC patients, but the expression of some ESRP-target exons correlated with the good prognosis and with the expression of Arkadia (also known as RNF111) in ccRCC. more...