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Links from GEO DataSets

Items: 5

1.

Unique microRNA profiles in EGFR-mutated lung adenocarcinomas

(Submitter supplied) We have examined the microRNA expression in 154 lung adenocarcinoma samples and 20 paired normal lung tissue samples and investigated the microRNA expression to clinical variables, EGFR- and KRAS- mutational status and time to progression.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL16770
174 Samples
Download data: TXT
Series
Accession:
GSE48414
ID:
200048414
2.

Genome-wide DNA methylation signature in lung adenocarcinomas has prognostic impact [gene expression]

(Submitter supplied) Purpose: DNA methylation alterations are early events in tumorigenesis and important in the regulation of gene expression in cancer cells. Lung cancer has in general a poor prognosis, and a deeper insight into the epigenetic landscape in lung adenocarcinoma tumors and its prognostic implications is needed. Experimental Design: We determined whole-genome DNA methylation profiles of 164 lung adenocarcinoma samples and 19 samples of matched normal lung tissue samples using the Illumina Infinium 450K array [GSE66836]. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14550
121 Samples
Download data: TXT
Series
Accession:
GSE66863
ID:
200066863
3.

Genome-wide DNA methylation signature in lung adenocarcinomas has prognostic impact

(Submitter supplied) Purpose: DNA methylation alterations are early events in tumorigenesis and important in the regulation of gene expression in cancer cells. Lung cancer has in general a poor prognosis, and a deeper insight into the epigenetic landscape in lung adenocarcinoma tumors and its prognostic implications is needed. Experimental Design: We determined whole-genome DNA methylation profiles of 164 lung adenocarcinoma samples and 19 samples of matched normal lung tissue samples using the Illumina Infinium 450K array. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
183 Samples
Download data: IDAT
Series
Accession:
GSE66836
ID:
200066836
4.

Small and large RNA sequencing of a Kras G12D mouse model of lung adenocarcinoma

(Submitter supplied) Mice bearing a G12D activating mutation in Kras consistently develop lung adenocarcinomas in a manner analogous to humans. By performing small and large RNA sequencing on KrasG12D tumors from F1 hybrid mice we were able to identify genes and microRNAs differentially expressed in these tumor samples. Quantification of reads that cover single nucleotide polymorphisms that distinguish between the parental mouse strains enabled an analysis of allele specific expression and imprinting status in these tumors.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL13112 GPL9250
12 Samples
Download data: TXT
Series
Accession:
GSE43028
ID:
200043028
5.

Smoking Status Impacts microRNA Mediated Prognosis and Lung Adenocarcinoma Biology

(Submitter supplied) Cigarette smoke is associated with the majority of lung cancers: however, 25% of lung cancer patients are non-smokers, and half of all newly diagnosed lung cancer patients are former smokers. Lung tumors exhibit distinct epidemiological, clinical, pathological, and molecular features depending on smoking status, suggesting divergent mechanisms underlie tumorigenesis in smokers and non-smokers. MicroRNAs (miRNAs) are integral contributors to tumorigenesis and mediate biological responses to smoking. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL11154
188 Samples
Download data: TXT
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