Similar studies for GEO DataSets (Select 200055594) - GEO DataSets

Select item 2000555941.

Gene expression profiling of breast fibroadenomas

(Submitter supplied) Fibroadenomas are the most common benign breast tumors in women under 30. Unlike their malignant counterparts, relatively molecular profiling has been done on fibroadenomas. Here we performed gene expression profiling on ten fibroadenomas in order to better characterize these tumors. Through targeted amplicon sequencing, we have found that six of these tumors have MED12 mutations. We show that the MED12 mutations, among others, are associated with activated estrogen signaling, as well as increased invasiveness through upregulation of ECM remodelling genes.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17811
10 Samples

Download data: CEL

Series

Accession:: GSE55594

ID:: 200055594

Select item 2000306732.

Comparison of Gene expression profiles between myometrium, MED12 mutation positive uterine leiomyomas and MED12 wildtype uterine leiomyomas

(Submitter supplied) Gene expression profiles of 10 uterine leiomyomas and their matched normal myometrium specimens were studied using Affymetrix GeneChip Human Genome U133 Plus 2.0 gene expression arrays. Four tumors displayed a codon 44 mutation, four carried a intron 1 mutation, and the remaining two displayed no MED12 mutation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13916
20 Samples

Download data: CEL

Series

Accession:: GSE30673

ID:: 200030673

Select item 2002249913.

Differential Expression of MED12-Associated Coding RNA 2 transcripts in Uterine Leiomyomas

(Submitter supplied) The objective of this study was to elucidate the expression profile of coding RNA transcripts in leiomyomas with and without MED12 mutation and their paired myometrium.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
38 Samples

Download data: XLS

Series

Accession:: GSE224991

ID:: 200224991

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002260174.

Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Other; Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL24676
27 Samples

Download data: BW, HIC, NARROWPEAK, TXT

Series

Accession:: GSE226017

ID:: 200226017

PubMed Full text in PMC Similar studies

Select item 2002260165.

Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization [MED12_G44N_spheroid_RNA_seq]

(Submitter supplied) We employed CRISPR knock-in with a sensitive PCR-based screening strategy to precisely engineer cells with mutant MED12 Gly44. Critically, the engineered myometrial SMC cells recapitulate several UF-like cellular, transcriptional and metabolic alterations, including enhanced proliferation rates in 3D spheres and altered Tryptophan/kynurenine. metabolism

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: BW, TXT

Series

Accession:: GSE226016

ID:: 200226016

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002260156.

Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization [Hi-C]

(Submitter supplied) We employed CRISPR knock-in with a sensitive PCR-based screening strategy to precisely engineer cells with mutant MED12 Gly44. Critically, the engineered myometrial SMC cells recapitulate several UF-like cellular, transcriptional and metabolic alterations, including enhanced proliferation rates in 3D spheres and altered Tryptophan/kynurenine. metabolism

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
2 Samples

Download data: BW, HIC

Series

Accession:: GSE226015

ID:: 200226015

PubMed Full text in PMC Similar studies

Select item 2002260147.

Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization [MED12_G44N_2D_RNA_seq]

(Submitter supplied) We employed CRISPR knock-in with a sensitive PCR-based screening strategy to precisely engineer cells with mutant MED12 Gly44. Critically, the engineered myometrial SMC cells recapitulate several UF-like cellular, transcriptional and metabolic alterations, including enhanced proliferation rates in 3D spheres and altered Tryptophan/kynurenine. metabolism

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: BW, TXT

Series

Accession:: GSE226014

ID:: 200226014

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002260138.

Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization [CUT&Tag]

(Submitter supplied) We employed CRISPR knock-in with a sensitive PCR-based screening strategy to precisely engineer cells with mutant MED12 Gly44. Critically, the engineered myometrial SMC cells recapitulate several UF-like cellular, transcriptional and metabolic alterations, including enhanced proliferation rates in 3D spheres and altered Tryptophan/kynurenine. metabolism

Organism:: Homo sapiens

Type:: Other

Platform:: GPL18573
5 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE226013

ID:: 200226013

PubMed Full text in PMC Similar studies

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