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Links from GEO DataSets

Items: 18

1.

PPARα mouse liver cistrome

(Submitter supplied) Autophagy is an evolutionally conserved catabolic process that recycles nutrients upon starvation and maintains cellular energy homeostasis1-3. Its acute regulation by nutrient sensing signaling pathways is well described, but its longer-term transcriptional regulation is not. The nuclear receptors PPARα and FXR are activated in the fasted or fed liver, respectively4,5. Here we show that both regulate hepatic autophagy. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: WIG
Series
Accession:
GSE61817
ID:
200061817
2.

FXR isoform selective transcriptional activation in mouse liver organoids

(Submitter supplied) The farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids that regulates metabolic processes. FXR is expressed as four isoforms (α1-4), and their relative abundance is specific to tissue and bio-energetic conditions (Correia JC et al. 2015). Depending on the FXR isoform expressed, there is a degree of selectivity in target-genes activation. In this dataset, we defined FXR-isoforms selective effects on transcription in mouse liver organoids after treatment with the FXR agonist Obeticholic acid(OCA). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
30 Samples
Download data: DIFF, TXT
Series
Accession:
GSE133734
ID:
200133734
3.

FXR isoform selective DNA binding in mouse liver organoids

(Submitter supplied) The farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids that regulates metabolic processes. FXR is expressed as four isoforms (α1-4), and their relative abundance is specific to tissue and bio-energetic conditions (Correia JC et al. 2015). Depending on the FXR isoform expressed, there is a degree of selectivity in target-genes activation. However, there is currently no data on how isoform-linked target selectivity is achieved. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
10 Samples
Download data: BED, BW
Series
Accession:
GSE133700
ID:
200133700
4.

FXR isoform selective effects on hepatoma cell line HepG2

(Submitter supplied) The farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids that regulates bile acid metabolism, glucose and cholesterol homeostasis. FXR is expressed as four isoforms (α1-4), and their relative abundance is tissue specific. Human livers express predominantly FXR isoforms α1 and α2. From mouse studies we know that the FXR agonist obeticholic acid (OCA) regulates expression of many genes in the liver. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
18 Samples
Download data: BW
Series
Accession:
GSE133659
ID:
200133659
5.

Cistrome profiles of Retinoids x Receptor alpha (RXRα) , Retinoic Acid Receptor alpha (RARα), and Retinoic Acid Receptor beta (RARβ) in livers of mice treated by control and retionic acid-containing diet

(Submitter supplied) Comparison between ChIP-Seq data of RARα and RARβ, between RAR and RXR, as well as between control and retinoic acid-treatment for each investigated nuclear receptors.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
7 Samples
Download data: BED
Series
Accession:
GSE53736
ID:
200053736
6.

Gene expression data of untreated and RA-treated wild type and RXRα-deficient mice liver

(Submitter supplied) Our project focuses on retinoic acid (RA) effect on hepatic lipid homeostasis. Even though RA has more than one receptor including retinoids x receptor (RXR) and retinoic acid receptor (RAR), most probably, RA effect on lipid homeostasis is mediated by RXR and its partners such as PXR, FXR, and PPAR. So we treated the wild type and RXRα-knockout mice by retinoic acid to check the global gene expression especially for lipid homeostasis genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
12 Samples
Download data: CEL
Series
Accession:
GSE50028
ID:
200050028
7.

Role of Retinoids x Receptor and Retinoic Acid Receptor in Mouse Liver

(Submitter supplied) Genome-wide binding of Retinoids x Receptor and Retinoic Acid Receptor in mouse liver was described
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
3 Samples
Download data: BAR, TXT
Series
Accession:
GSE46762
ID:
200046762
8.

Coagulopathy in Malnourished Mice is Sexually Dimorphic and Regulated by Nutrient-sensing Nuclear Receptors

(Submitter supplied) Liver dysfunction including coagulopathy is a prominent feature of proteinenergy malnutrition. To identify mechanisms underlying malnutrition-associated coagulopathy, we administered low-protein low-fat diet to lactating dams and examined hepatic transcription and plasma coagulation parameters in young adult weanlings. Malnutrition impairs growth and liver synthetic function more severely in males versus females. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
19 Samples
Download data: TXT
Series
Accession:
GSE156856
ID:
200156856
9.

The nuclear Bile Acid Receptor FXR is a PKA- and FOXA2- sensitive Activator of Fasting Hepatic Gluconeogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
32 Samples
Download data: CEL
Series
Accession:
GSE113575
ID:
200113575
10.

The nuclear Bile Acid Receptor FXR is a PKA- and FOXA2- sensitive Activator of Fasting Hepatic Gluconeogenesis [modulated FOXA2/FXR]

(Submitter supplied) Identified genes deregulated in mouse primary hepatocytes after modulation of expression/activity of FOXA2 and FXR in glucagon or insulin state
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
24 Samples
Download data: CEL
Series
Accession:
GSE113549
ID:
200113549
11.

The nuclear Bile Acid Receptor FXR is a PKA- and FOXA2- sensitive Activator of Fasting Hepatic Gluconeogenesis [glucacon/GW4064]

(Submitter supplied) Identified genes deregulated in mouse primary hepatocytes after glucagon and /or GW4064 treatment
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
8 Samples
Download data: CEL
Series
Accession:
GSE113526
ID:
200113526
12.

DEHP activation of PPAR(alpha) and CAR regulartory pathway in mouse liver

(Submitter supplied) Characterization of Peroxisome Proliferator-Activated Receptor alpha (PPAR(alpha)) - Independent Effects of PPAR(alpha) Activators in the Rodent Liver: Di-(2-ethylhexyl) phthalate Activates the Constitutive Activated Receptor data files in this series indicate the involvement of PPAR(alpha) and CAR regulatory pathway after DEHP treatment. Keywords: gene expression/microarray
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3748
Platform:
GPL6246
15 Samples
Download data: CEL
Series
Accession:
GSE18564
ID:
200018564
13.
Full record GDS3748

Peroxisome proliferator-activated receptor alpha deficiency effect on phthalate-exposed liver

Analysis of livers from peroxisome proliferator-activated receptor (PPAR) α-null animals exposed to the plasticizer di-(2-ethylhexyl) phthalate (DEHP). DEHP increases liver tumors in the absence of PPARα. Results provide insight into DEHP-induced transcriptional changes independent of PPARα.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE18564
15 Samples
Download data: CEL
14.

Glucagon-receptor signaling regulates energy metabolism via hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

(Submitter supplied) Glucagon, an essential regulator of glucose and lipid metabolism, also promotes weight loss, in part through potentiation of fibroblast-growth factor 21 (FGF21) secretion. However, FGF21 is only a partial mediator of metabolic actions ensuing from GcgR-activation, prompting us to search for additional pathways. Intriguingly, chronic GcgR agonism increases plasma bile acid levels. We hypothesized that GcgR agonism regulates energy metabolism, at least in part, through farnesoid X receptor (FXR). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
8 Samples
Download data: XLSX
Series
Accession:
GSE135881
ID:
200135881
15.

Genome wide comparison of the inducible transcriptomes of CAR, PXR and PPARα in primary human hepatocytes

(Submitter supplied) To identify the CAR-, PXR- and PPARα-specific genome-wide expression changes, hepatocyte cultures from six individual donors were treated with the prototypical ligands for CAR (CITCO), PXR (rifampicin) and PPARα (WY14,643) as well as DMSO (vehicle control). Afterwards, the mRNA expression in these samples was determined utilizing Affymetrix® microarrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
24 Samples
Download data: CEL
Series
Accession:
GSE76148
ID:
200076148
16.

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

(Submitter supplied) Autophagy is essential for cellular survival and energy homeostasis under nutrient deprivation. Despite the emerging importance of nuclear events in autophagy regulation, epigenetic control of autophagy gene transcription remains unclear. Here, we identify Jumonji-D3 (JMJD3/KDM6B) histone demethylase as a key epigenetic activator of hepatic autophagy. Upon fasting-induced fibroblast growth factor-21 (FGF21) signaling, JMJD3 epigenetically upregulated global autophagy-network genes, including Tfeb, Atg7, Atgl, and Fgf21, through demethylation of histone H3K27-me3, resulting in autophagy-mediated lipid degradation. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9250
8 Samples
Download data: BW, NARROWPEAK
Series
Accession:
GSE138157
ID:
200138157
17.

Histone demethylase JMJD3 is a key epigenetic activator of FGF21 signaling-induced hepatic autophagy and lipid degradation

(Submitter supplied) Autophagy is essential for cellular survival and energy homeostasis under nutrient deprivation. Despite the emerging importance of nuclear events in autophagy regulation, epigenetic control of autophagy gene transcription remains unclear. Here, we identify Jumonji-D3 (JMJD3/KDM6B) histone demethylase as a key epigenetic activator of hepatic autophagy. Upon fasting-induced fibroblast growth factor-21 (FGF21) signaling, JMJD3 epigenetically upregulated global autophagy-network genes, including Tfeb, Atg7, Atgl, and Fgf21, through demethylation of histone H3K27-me3, resulting in autophagy-mediated lipid degradation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: TXT
Series
Accession:
GSE137555
ID:
200137555
18.

Reversible internalization of cytoplasm into the nucleus in senescent cells

(Submitter supplied) Cellular senescence is a heterogeneous phenotype, driven by diverse effector programs, which result in irreversible growth arrest, DNA damage, production of complex secretome and metabolic reprogramming1,2. Here we show that in liver-specific Setd8-KO mice, after mitogen treatment, a significant number of hepatocytes become senescent, have enlarged nuclei and increased nuclear envelope plasticity. Despite cell cycle arrest, senescent cells in Setd8-deficient mice retain inherent capability to replicate DNA, resulting in endoreduplication-driven chromosomal hyperploidy. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
55 Samples
Download data: BROADPEAK, BW, NARROWPEAK, TSV, TXT
Series
Accession:
GSE242719
ID:
200242719
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