Similar studies for GEO DataSets (Select 200063203) - GEO DataSets

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Items: 20

Select item 2000632031.

A restricted period for formation of Outer Subventricular Zone defined by Cdh1 and Trnp1 levels

(Submitter supplied) The Outer Subventricular Zone (OSVZ) is a germinal layer playing key roles in the development of the neocortex, with particular relevance in gyrencephalic species like human and ferret where it contains abundant basal Radial Glia Cells (bRGCs) that promote cortical expansion. Here we identify a brief period in ferret embryonic development when apical RGCs generate a burst of bRGCs that become founders of the OSVZ. more...

Organism:: Mustela putorius furo

Type:: Expression profiling by array

Platform:: GPL19111
11 Samples

Download data: TXT

Series

Accession:: GSE63203

ID:: 200063203

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001595962.

Non-coding RNAs shape cortical neurons developmental trajectories

(Submitter supplied) A hallmark of cortical evolution is the high dynamic subventricular zone (SVZ) expansion, where basal progenitors (BPs) amplify and neuronal transcriptional programs unfold. How non-coding molecular factors such as microRNAs influence these developmental trajectories and regulate the acquisition of cortical type identities is largely unknown. Here we demonstrate that miR-137 and miR-122 regulate the positioning and identity features of superficial layer cortical neurons by acting at distinct steps of their developmental trajectories. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2524 Samples

Download data: TSV

Series

Accession:: GSE159596

ID:: 200159596

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000606873.

Sharp changes in gene expression levels along germinal layers distinguish the development of gyrencephaly

(Submitter supplied) Gyrencephalic species develop folds in the cerebral cortex in a stereotypic manner, but the genetic mechanisms underlying this unique patterning process are unknown. We present a large-scale transcriptomic analysis of individual germinal layers in the developing cortex of the gyrencephalic ferret, comparing between regions prospective of fold and fissure. We find unique transcriptional signatures in each germinal compartment, indicating that thousands of genes are differentially expressed between regions, including ~80% of genes mutated in human cortical malformations. more...

Organism:: Mustela putorius furo

Type:: Expression profiling by array

Platform:: GPL19111
19 Samples

Download data: TXT

Series

Accession:: GSE60687

ID:: 200060687

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Select item 2001210084.

A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex

(Submitter supplied) A specific subpopulation of neural progenitor cells, the basal radial glial cells (bRGCs) of the outer subventricular zone (OSVZ), are thought to have a key role in the evolutionary expansion of the mammalian neocortex. In the developing lissencephalic mouse neocortex, bRGCs exist at low abundance and show significant molecular differences from bRGCs in developing gyrencephalic species. Here, we demonstrate that the developing mouse medial neocortex (medNcx), in contrast to the canonically studied lateral neocortex (latNcx), exhibits an OSVZ and an abundance of bRGCs similar to that in developing gyrencephalic neocortex. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: TXT

Series

Accession:: GSE121008

ID:: 200121008

PubMed Similar studies SRA Run Selector

Select item 2001209765.

A novel population of Hopx-dependent human-like basal radial glial cells in the developing mouse neocortex

(Submitter supplied) A specific subpopulation of neural progenitor cells, the basal radial glia cells (bRGCs) of the outer subventricular zone (OSVZ), are thought to have a key role in the evolutionary expansion of mammalian neocortex. In the developing lissencephalic mouse neocortex, bRGCs exist at low abundance and show significant molecular differences from bRGCs in developing gyrencephalic species. Here, we demonstrate that developing mouse medial neocortex, in contrast to the canonically studied lateral neocortex, exhibits an OSVZ and an abundance of bRGCs similar to that in developing gyrencephalic neocortex. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
221 Samples

Download data: CSV, TXT

Series

Accession:: GSE120976

ID:: 200120976

PubMed Similar studies SRA Run Selector

Select item 2001655556.

Single cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenic lineages.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21103 GPL24247
5 Samples

Download data: MTX, RDS, TSV

Series

Accession:: GSE165555

ID:: 200165555

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Select item 2001655547.

Single cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenic lineages. [single whole-cell]

(Submitter supplied) Purpose: While great progress has been made in understanding the differences in regional stem cell potential using viral and genetic lineage tracing strategies, the core molecular heterogeneity that underlies these regional differences is largely unknown. Methods: Here we present a single whole-cell sequencing dataset of microdissected adult hGFAP:GFP mouse V-SVZ. Four samples were (two samples from male mice, two samples from female mice) multiplexed & combined using MULTI-Seq barcodes (McGinnes et al. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
1 Sample

Download data: MTX, RDS, TSV, XLSX

Series

Accession:: GSE165554

ID:: 200165554

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001655518.

Single cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenic lineages. [single nucleus sequencing]

(Submitter supplied) Purpose: While great progress has been made in understanding the differences in regional stem cell potential using viral and genetic lineage tracing strategies, the core molecular heterogeneity that underlies these regional differences is largely unknown. Methods: Here we present a single nucleus sequencing dataset of four microdissected regions of adult CD1 wild type mouse ventricular-subventricular zones (V-SVZ). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: MTX, RDS, TSV

Series

Accession:: GSE165551

ID:: 200165551

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Select item 2001422539.

microRNA profiling of mouse cortical progenitors and neurons reveals miR-486-5p as a regulator of neurogenesis

(Submitter supplied) MicroRNAs (miRNAs) are short (~22 nt) single-stranded non-coding RNAs that regulate gene expression at the post-transcriptional level. Over the past years, many studies have extensively characterized the involvement of miRNA-mediated regulation in neurogenesis and brain development. However, a comprehensive catalog of cortical miRNAs cell-specifically expressed in progenitor types of the developing mammalian cortex is still missing. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17021
9 Samples

Download data: TXT

Series

Accession:: GSE142253

ID:: 200142253

PubMed Similar studies SRA Run Selector

Select item 20007421010.

A Primate lncRNA Mediates Notch Signaling During Neuronal Development by Sequestering miRNA

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
70 Samples

Download data

Series

Accession:: GSE74210

ID:: 200074210

PubMed Full text in PMC Similar studies

Select item 20007420711.

A Primate lncRNA Mediates Notch Signaling During Neuronal Development by Sequestering miRNA [single cell sequencing analysis]

(Submitter supplied) Long non-coding RNAs (lncRNAs) are a diverse category of transcripts with poor conservation and have expanded greatly in primates, particularly in their brain. We identified a lncRNA, which has acquired 16 microRNA response elements (MREs) for miR-143-3p in the Catarrhini branch of primates. This lncRNA termed LncND (neuro-development) gets expressed in neural progenitor cells and then declines in mature neurons. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
60 Samples

Download data: TXT

Series

Accession:: GSE74207

ID:: 200074207

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007398212.

A Primate lncRNA Mediates Notch Signaling During Neuronal Development by Sequestering miRNA [SHSY5Y cells]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
10 Samples

Download data: TXT

Series

Accession:: GSE73982

ID:: 200073982

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20005260813.

Novel primate miRNAs co-evolved with ancient target genes in germinal zone specific expression patterns

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Macaca fascicularis

Type:: Non-coding RNA profiling by high throughput sequencing; Other

Platforms:: GPL13393 GPL9052 GPL17971
36 Samples

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Series

Accession:: GSE52608

ID:: 200052608

PubMed Full text in PMC Similar studies

Select item 20005260714.

Novel primate miRNAs co-evolved with ancient target genes in germinal zone specific expression patterns [RISC trap immunoprecipitation]

(Submitter supplied) Major non primate-primate differences in corticogenesis include the dimensions, precursor lineages and developmental timing of the germinal zones (GZ). microRNAs (miRNAs) of laser dissected GZ compartments and cortical plate (CP) from embryonic E80 macaque visual cortex were deep sequenced. The CP and the GZ including Ventricular Zone (VZ), outer and inner subcompartments of the Outer SubVentricular Zone (OSVZ) in area 17 displayed unique miRNA profiles. more...

Organism:: Homo sapiens

Type:: Other

Platforms:: GPL9052 GPL13393
16 Samples

Download data: TXT

Series

Accession:: GSE52607

ID:: 200052607

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Select item 20005260615.

Novel primate miRNAs co-evolved with ancient target genes in germinal zone specific expression patterns [miRNA-Seq]

Organism:: Macaca fascicularis

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17971
20 Samples

Download data: TXT

Series

Accession:: GSE52606

ID:: 200052606

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006713516.

miR-124, -128 and -137 orchestrate neural differentiation by acting on overlapping gene sets containing a highly connected transcription factor network

(Submitter supplied) We report the application of RNA-seq profiling on neural stem cells after antagomiR transfection.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
27 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE67135

ID:: 200067135

PubMed Similar studies SRA Run Selector

Select item 20009073417.

Primate-specific gene TMEM14B promotes cortical expansion and folding

(Submitter supplied) A massively expanded outer subventricular zone (OSVZ) in the primate and human has been proposed for generating majority of neocortical neurons, which consists of basally located radial glia cells. Previous studies with various strategies have tried to recognize genes specifically expressed in those cells; however, the molecular and cellular features of these cells still remain uncertain. By profiling gene expression across single cells isolated from cellular anatomy location and subtype sorting, we identified a primate-specific gene TMEM14B as a novel marker for basally located radial glia. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL16791
46 Samples

Download data: XLSX

Series

Accession:: GSE90734

ID:: 200090734

PubMed Similar studies SRA Run Selector

Select item 20019551018.

FOXP1 Orchestrates Neurogenesis in Human Cortical Basal Progenitors

(Submitter supplied) We report the application of single-molecule-based sequencing technology for high-throughput profiling of Forkhead Box P1, in human iPSC-derived forebrain organoids with and without FOXP1. We generated cell type-specific gene expression profiles of FOXP1 in progenitors and excitatory neurons of dorsal telencephalic lineage.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL18573
9 Samples

Download data: H5AD

Series

Accession:: GSE195510

ID:: 200195510

PubMed Full text in PMC Similar studies

Select item 20006500019.

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion

(Submitter supplied) The evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Here, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a novel approach from developing mouse and human neocortex. We identify 56 genes preferentially expressed in human apical and basal radial glia that lack mouse orthologs. more...