Similar studies for GEO DataSets (Select 200065238) - GEO DataSets

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Items: 13

Select item 2000652381.

Transcriptome analysis of Wnt3a-treated triple-negative breast cancer cell lines.

(Submitter supplied) We analyzed the transcriptome of two different triple negative breast cancer (TNBC) cell lines to define a comprehensive list of Wnt target genes. Cells were treated with Wnt3a for 6h, 12h or 24h. We found up-regulated and down-regulated genes in response to Wnt3a treatment. They are involved in the Wnt pathway itself, and also in TGFß, p53 and Hedgehog pathways. Thorough characterization of these novel potential Wnt target genes may reveal new regulators of the canonical Wnt pathway. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15640
36 Samples

Download data: CEL

Series

Accession:: GSE65238

ID:: 200065238

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000652162.

Expression profiling of breast cancer samples from Institut Curie (Maire cohort)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL570 GPL14877
356 Samples

Download data: CEL

Series

Accession:: GSE65216

ID:: 200065216

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000652123.

Expression profiling of breast cancer samples from Institut Curie (Maire cohort) -- BrainArray CDF

(Submitter supplied) Transcriptome analysis of 130 breast cancer samples (41 TNBC ; 30 Her2 ; 30 Luminal B and 29 Luminal A), 11 normal breast tissue samples and 14 TNBC cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14877
178 Samples

Download data: CEL, TXT

Series

Accession:: GSE65212

ID:: 200065212

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000651944.

Expression profiling of breast cancer samples from Institut Curie (Maire cohort) --Affy CDF

(Submitter supplied) Transcriptome analysis of 130 breast cancer samples (41 TNBC ; 30 Her2 ; 30 Luminal B and 29 Luminal A), 11 normal breast tissue samples and 14 TNBC cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
178 Samples

Download data: CEL, TXT

Series

Accession:: GSE65194

ID:: 200065194

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000274475.

FZD7 Plays a Critical Role in Triple Negative Breast Cancer Proliferation

(Submitter supplied) Breast cancer is genetically and clinically heterogeneous. Triple negative cancer (TNBC) is a subtype of breast cancer usually associated with poor outcome and lack of benefit from target therapy. A pathway analysis in a microarray study was performed using TNBC compared with non-triple negative breast cancer (non-TNBC). Overexpression of several Wnt pathway genes, such as frizzled homolog 7 (FZD7), Low density lipoprotein receptor-related protein 6 (LRP6) and transcription factor 7 (TCF7) has been observed in TNBC. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4069
Platform:: GPL6244
19 Samples

Download data: CEL, CHP

Series

Accession:: GSE27447

ID:: 200027447

Select item 40696.

Triple negative breast cancer

Analysis of triple negative breast cancer (TNBC) tumors. TNBC is usually associated with poor outcome, and is characterized by lack of estrogen and progesterone hormone receptors and lack of overexpression of HER2. Results provide insight into the molecular basis of tumorigenesis of TNBC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL6244
Series:: GSE27447
19 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4069

ID:: 4069

Select item 2000599497.

Expression data from human dental follicle cells

(Submitter supplied) We analysed the genexpression of dental follicle cells (DFCs) after 3 days osteogenic differentiation with BMP2 after transfection with a DLX3 plasmid (pDLX3) and after transfection with an empty plasmid (pEV)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL11532
4 Samples

Download data: CEL

Series

Accession:: GSE59949

ID:: 200059949

Select item 2001031758.

The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells

(Submitter supplied) The WNT/β-catenin signaling pathway is a prominent player in many developmental processes, including gastrulation, anterior-posterior axis specification, organ and tissue development and homeostasis. Here, we use human pluripotent stem cells (hPSCs) to study the dynamics of the transcriptional response to exogenous activation of the WNT pathway. We describe a mechanism involving the WNT target gene SP5 that leads to termination of the transcriptional program initiated by WNT signaling. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18573 GPL11154
18 Samples

Download data: TXT

Series

Accession:: GSE103175

ID:: 200103175

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000320969.

Gene expression in Rspo2 and/or Wnt3a treated C57MG mouse mammary epithelial cells

(Submitter supplied) R-spondins (Rspos) comprise a family of four secreted proteins that have important roles in cell proliferation, cell fate determination and organogenesis. Rspos typically exert their effects by potentiating the Wnt/β-catenin signaling pathway. To systematically investigate the impact of Rspo/Wnt on gene expression, we performed a microarray analysis using C57MG mouse mammary epithelial cells treated with recombinant Rspo2 and/or Wnt3a.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
12 Samples

Download data: TXT

Series

Accession:: GSE32096

ID:: 200032096

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012778910.

Gene expression profiling induced by high dose ionizing radiation on MDA-MB-231 cells

(Submitter supplied) Radiation therapy (RT) remains a vital component of the curative multimodality therapy for many types of cancer including breast cancer (BC). Even if great number of BC patients receive RT, not all of them report benefits, due to radioresistance activation depending also by hormone receptor status. We analyze and compare molecular responses, in term of gene expression profile (GEP) changes, induced by high dose of Ionizing Radiation (IR), in MDA-MB-231 with ER-/PR-HER2- receptor status. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
18 Samples

Download data: TXT

Series

Accession:: GSE127789

ID:: 200127789

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010900411.

Transcriptome analysis of LRP5- and LRP6-depleted HCC38 cells.

(Submitter supplied) In order to characterize the differences between the co-receptors LRP5 and LRP6, we have analyzed the transcriptome of HCC38 cells - a triple negative breast cancer cell line - 24, 48 and 72 hours following the depletion of LRP5 or LRP6 using siRNAs.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL19264
30 Samples

Download data: CEL

Series

Accession:: GSE109004

ID:: 200109004

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014273112.

Transcriptome profiling of tumors from Caucasian and African American triple negative breast cancer (TNBC) patients.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
42 Samples

Download data: TXT

Series

Accession:: GSE142731

ID:: 200142731

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20014225813.

Transcriptome profiling of tumors from Kenyan triple negative breast cancer (TNBC) patients.

(Submitter supplied) Triple negative breast cancer is an aggressive phenotypic breast cancer characterized by ER negative, PR negative and Her2 negative immunohistochemistry status. We embarked on a study to explore the transcriptome of Kenyan TNBC patients and identify potential biomarkers specific to Kenyan population. The transcriptome sequencing of tumors from Kenyan TNBC patients and comparisons with African American and Caucasian TNBC transcriptomes revealed several interesting targets and dysregulated pathways.