Similar studies for GEO DataSets (Select 200070200) - GEO DataSets

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Items: 20

Select item 2000702001.

Engagement of the Aryl Hydrocarbon Receptor in Mycobacterium tuberculosis–Infected Macrophages Has Pleiotropic Effects on Innate Immune Signaling

(Submitter supplied) Understanding the mechanisms of host macrophage responses to Mycobacterium tuberculosis (M.tb.) is essential for uncovering potential avenues of intervention to boost host resistance to infection. Macrophage transcriptome profiling revealed M.tb. infection strongly induced expression of several enzymes controlling tryptophan (Trp) catabolism. This included indole 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2), which catalyze the rate-limiting step in the kynurenine pathway, producing ligands for the aryl hydrocarbon receptor (AHR). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
8 Samples

Download data: CEL, XLSX

Series

Accession:: GSE70200

ID:: 200070200

Select item 2000674272.

Mycobacterial infection induces a specific human innate immune response

(Submitter supplied) The innate immune system provides the first response to pathogen infection and orchestrates the activation of the adaptive immune system. Though a large component of the innate immune response is common to all infections, pathogen-specific innate immune responses have been documented as well. The innate immune response is thought to be especially critical for fighting infection with Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
156 Samples

Download data: TXT

Series

Accession:: GSE67427

ID:: 200067427

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2002231223.

Transcriptomic signatures reveal a shift towards an antiinflammatory gene expression profile but also the induction of type-I and type-II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages

(Submitter supplied) The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates a broad range of target genes involved in the xenobiotic response, cell cycle control and circadian rhythm. AhR is constitutively expressed in macrophages, acting as key regulator of cytokine production. While proinflammatory cytokines, i.e., IL-1β, IL-6, IL-12, are suppressed through AhR activation, anti-inflammatory IL-10 is induced. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
64 Samples

Download data: CSV, TXT

Series

Accession:: GSE223122

ID:: 200223122

PubMed Full text in PMC Similar studies

Select item 2000797334.

Gene expression data from Mycobacterium tuberculosis-infected WT and miR-155-/- bone-marrow derived macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13712
27 Samples

Download data: CEL

Series

Accession:: GSE79733

ID:: 200079733

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000797325.

Gene expression data from Mycobacterium tuberculosis-infected WT and miR-155-/- bone-marrow derived macrophages [validation]

(Submitter supplied) How the complex interaction between Mycobacterium tuberculosis (Mtb) and the host is regulated during infection is still not well understood. Using a systems biology approach, we demonstrate here that miR-155 is one of several microRNAs that regulate host gene expression over the first 48 hours of Mtb infection in macrophages. miR-155 regulates the cell survival of Mtb-infected macrophages through SHIP1/AKT signaling. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13712
12 Samples

Download data: CEL

Series

Accession:: GSE79732

ID:: 200079732

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Select item 2000797316.

Gene expression data from Mycobacterium tuberculosis-infected WT and miR-155-/- bone-marrow derived macrophages [timecourse]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13712
15 Samples

Download data: CEL

Series

Accession:: GSE79731

ID:: 200079731

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001194617.

Gut Adaptation of Ahr Expression Cell-intrinsically Restricts Group 2 Innate Lymphoid Cell Function

(Submitter supplied) Innate lymphoid cells (ILCs) are important for mucosal immunity. The intestine harbors all ILC subsets; however, how these cells orchestrate each other to achieve immune homeostasis and mount appropriate immunity during infection remains elusive. Here, we show that the adaptation of the aryl hydrocarbon receptor (Ahr) expression in the gut is a key regulatory mode for the host to keep the ILC balance. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
32 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE119461

ID:: 200119461

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000644278.

Time-dependent global gene expression profile of RAW264.7 cells infected with Mycobacterium tuberculosis H37Rv (Mtb)

(Submitter supplied) Transcriptional profiling of RAW264.7 cells infected with M. tuberculosis H37Rv at an MOI of 10 performed 4 and 24 hours post-infection.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13381
4 Samples

Download data: TXT

Series

Accession:: GSE64427

ID:: 200064427

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001603079.

Kynurenine treatment of herpesivrus stimulated iCD103 dendritic cells

(Submitter supplied) We report the gene expression (obtained by next generation RNAseq) of inducible CD103+ dendritic cells, iCD103 cells, stimulated with both murine herpesvirus-68 and the immunomodulatory tryptophan derivative kynurenine (kyn). This study provides data on how tryptophan derivatives can modulate pro-inflammatory cytokine expression in virus treated dendritic cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
12 Samples

Download data: CSV

Series

Accession:: GSE160307

ID:: 200160307

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008880110.

Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis

(Submitter supplied) Macrophages play an essential role in the early immune response to Mycobacterium tuberculosis and are the cell type preferentially infected in vivo. Primary macrophages and macrophage-like cell lines are commonly used as infection models, although the physiological relevance of cell lines, particularly for host-pathogen interaction studies, is debatable. Here we use high-throughput RNA-sequencing to analyse transcriptome dynamics of two macrophage models in response to M. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
36 Samples

Download data: TXT

Series

Accession:: GSE88801

ID:: 200088801

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009658811.

Development of gene expression for FMDV-infected RAW264.7 cell

(Submitter supplied) To determine whether type O FMDV-infected macrophage can release a variety of cytokines and activate innate immune responses, we have taken systematic functional genomics studies using microarray technology on differences expression gene of FMDV-infected and FMDV-uninfected mouse monocyte macrophage (RAW264.7 cells). We examined the expression patterns of 39,430 mouse genes probes, using Agilent mouse gene expression microarray. more...

Organism:: Mus; Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
6 Samples

Download data: TXT

Series

Accession:: GSE96588

ID:: 200096588

Select item 20006433512.

Mycobacterium tuberculosis H37Ra-infected macrophages response to T0901317

(Submitter supplied) Host macrophage transcriptional responses to intracellular pathogens remain poorly characterized. We screened transcriptional enhancers engaged in response to M. tuberculosis (Mtb) infection by ChIPseq analysis of histone H3 lysine 4 monomethylation (H3K4me1). De novo monomethylation during infection was associated with genes implicated in host defense and apoptosis. These regions were enriched for binding sites for ETS transcription factor family members and response elements for nuclear receptors, including liver X receptors (LXRs) and peroxisomal proliferator activated receptors (PPARs), many of which were encompassed by transposable elements. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
6 Samples

Download data: CEL

Series

Accession:: GSE64335

ID:: 200064335

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010204513.

G-Protein-Coupled Receptor 68 Negatively Regulates IL-22 Production in Human Th17 Cells

(Submitter supplied) Purpose: To identify novel genes regulated by the aryl hydrocarbon receptor that influence human Th17 cell function. Methods: Naïve CD4 T cells from peripheral blood of six healthy human volunteers were cultured under four experimental conditions for three days: anti-CD3 and anti-CD28 antibodies (Media control), Media with Th17 conditions (IL-6, TGF-b, IL-1b, IL-23), Th17+FICZ and Th17+CH223191. Total RNA was extracted from each sample on day 3 and sequenced in a paired-end 2x50bp strategy on an Illumina HiSeq1500. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18460
24 Samples

Download data: CSV, TXT

Series

Accession:: GSE102045

ID:: 200102045

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20005867714.

IL-10 from intestinal macrophages prevents excessive innate immune responses to bacteria by limiting IL-23 synthesis

(Submitter supplied) Innate immune responses must be regulated in the intestine to prevent excessive inflammation. Here, using gene reporter mice, we show that a subset of mouse colonic macrophages constitutively produced the anti-inflammatory cytokine IL-10. In mice infected with Citrobacter rodentium, which is considered similar to enteropathogenic Escherichia coli infection in humans, macrophage IL-10 was required to prevent intestinal pathology and to promote survival. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL, TXT

Series

Accession:: GSE58677

ID:: 200058677

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007259115.

Time-dependent global gene expression profile of J774A.1 cells treated with ManLAM in the absence or presence of GW9662

(Submitter supplied) Transcriptional profiling of J7774A.1 cells treated with ManLAM ( 5ug/ml) for 6 h in the absence or presence of GW9662

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13381
8 Samples

Download data: TXT

Series

Accession:: GSE72591

ID:: 200072591

Select item 20013103116.

Group 3 innate lymphoid cells mediate early protective immunity against Mycobacterium tuberculosis

(Submitter supplied) We report the phenotype of human lung ILC2 and ILC3 populations from individuals with tuberculosis (TB) and non-TB cancer controls. We find that ILC2s demonstrate moderate transcriptional differences in TB infection, whereas ILC3s demonstrate large differences.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
24 Samples

Download data: TXT

Series

Accession:: GSE131031

ID:: 200131031

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20005773617.

Gene expression comparison between Mycobacterium tuberculosis infected monocytes from tuberculous and healthy elders

(Submitter supplied) Differences in the activity of monocytes/macrophages, important target cells of Mycobacterium tuberculosis, might influence tuberculosis progression. With the purpose of identifying candidate genes for tuberculosis susceptibility we infected with M. tuberculosis monocytes from both, healthy elders (a tuberculosis susceptibility group) and elderly tuberculosis patients, and performed a microarray experiment. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
15 Samples

Download data: TXT

Series

Accession:: GSE57736

ID:: 200057736

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012754118.

Gene Expression by granuloma macrophages from resistant and susceptible mice after 4h of phagocytosis of metacyclical Leishmania major

(Submitter supplied) The goal of this experiment was to identify genes which are differentially regulated between Leishmania major- infected granuloma macrophages from mice resistant (C57 Bl/6) and susceptible (BALB/c) to experimental leishmaniasis

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL81
12 Samples

Download data: CEL

Series

Accession:: GSE127541

ID:: 200127541

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20016739519.

Expression profiles of the spheroids derived from colon cancer patients

(Submitter supplied) Among the examined genes, none of genes associated with high frequency microsatellite instability (MSI-H) in the panel was mutated (MLH1, MSH2, POLE). In addition, clustering analyses based on RNA-seq data indicated that expression profiles of the spheroids were more similar to colon cancer cells in the CMS-2 and CMS-3 category than those in the MSI-H-related CMS-1. These data suggested that all the examined spheroids were associated with microsatellite stable (MSS) phenotype.