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Links from GEO DataSets

Items: 20

1.

Molecular function of Lhx1 in early mouse development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL6887 GPL13112
22 Samples
Download data
Series
Accession:
GSE70958
ID:
200070958
2.

Molecular function of Lhx1 in early mouse development (ChIP-Seq)

(Submitter supplied) ChIP-seq using anti-Lhx1 antibody to map genomic binding of Lhx1 in stably transfected P19 mouse embryonic carcinoma cells
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: WIG
Series
Accession:
GSE70957
ID:
200070957
3.

Molecular function of Lhx1 in early mouse development (BeadChip)

(Submitter supplied) Expression profiling of wild-type and Lhx1 null mouse definitive endoderm cultures using Illumina whole genome mouse V2 arrays. The hypothesis tested was that Lhx1 regulates gene expression of definitive endoderm and anterior mesendoderm genes
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
16 Samples
Download data: TXT
Series
Accession:
GSE70956
ID:
200070956
4.

LIM-Domain-Binding 1 maintains the terminally-differentiated state of pancreatic β-cells

(Submitter supplied) Utilize high-throughput transcriptomic and cistromic analysis to determine the functional requirement for LDB1 and ISL1 in mature murine pancreatic β-cells while simultaneously assessing their functional interdependence at the chromatin level.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
21 Samples
Download data: BED, BW, XLSX
Series
Accession:
GSE84759
ID:
200084759
5.

Eomes related gene regulation in Definitive Endoderm

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
Platform:
GPL19057
30 Samples
Download data: BW
Series
Accession:
GSE94250
ID:
200094250
6.

Eomes related gene regulation in Definitive Endoderm (ATAC-seq)

(Submitter supplied) Precisely co-ordinated activation of lineage specific transcription factors direct cell fate decisions during mouse early development. The T-box transcription factor Eomes is dynamically expressed during mouse gastrulation and is a key regulator of the anterior visceral endoderm (AVE), cardiac mesoderm and definitive endoderm (DE) lineages. The cis-acting regulatory elements that direct spatiotemporally restricted Eomes expression domains have yet to be elucidated. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
6 Samples
Download data: BW
Series
Accession:
GSE94249
ID:
200094249
7.

Eomes related gene regulation in Definitive Endoderm (NG Capture-C)

(Submitter supplied) Precisely co-ordinated activation of lineage specific transcription factors direct cell fate decisions during mouse early development. The T-box transcription factor Eomes is dynamically expressed during mouse gastrulation and is a key regulator of the anterior visceral endoderm (AVE), cardiac mesoderm and definitive endoderm (DE) lineages. The cis-acting regulatory elements that direct spatiotemporally restricted Eomes expression domains have yet to be elucidated. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL19057
18 Samples
Download data: TXT
Series
Accession:
GSE94051
ID:
200094051
8.

Eomes related gene regulation in Definitive Endoderm (ChIP-seq)

(Submitter supplied) Precisely co-ordinated activation of lineage specific transcription factors direct cell fate decisions during mouse early development. The T-box transcription factor Eomes is dynamically expressed during mouse gastrulation and is a key regulator of the anterior visceral endoderm (AVE), cardiac mesoderm and definitive endoderm (DE) lineages. The cis-acting regulatory elements that direct spatiotemporally restricted Eomes expression domains have yet to be elucidated. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
6 Samples
Download data: BW
Series
Accession:
GSE94048
ID:
200094048
9.

A gene regulatory network driven by LIM homeobox 1 (LHX1) for embryonic head development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL13112 GPL17543
24 Samples
Download data: IDAT
Series
Accession:
GSE117761
ID:
200117761
10.

A gene regulatory network driven by LIM homeobox 1 (LHX1) for embryonic head development (Microarray)

(Submitter supplied) Development of the embryonic head is driven by the activity of gene regulatory networks of transcription factors. LHX1 is a homeobox transcription factor that plays an essential role in the formation of the embryonic head. The loss of Lhx1 function results in anterior truncation of the embryo caused by the disruption of morphogenetic movement of tissue precursors and the dysregulation of WNT signaling activity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17543
12 Samples
Download data: CSV, IDAT
Series
Accession:
GSE117760
ID:
200117760
11.

A gene regulatory network driven by LIM homeobox 1 (LHX1) for embryonic head development (RNA-seq)

(Submitter supplied) Development of the embryonic head is driven by the activity of gene regulatory networks of transcription factors. LHX1 is a homeobox transcription factor that plays an essential role in the formation of the embryonic head. The loss of Lhx1 function results in anterior truncation of the embryo caused by the disruption of morphogenetic movement of tissue precursors and the dysregulation of WNT signaling activity. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
12 Samples
Download data: CSV
Series
Accession:
GSE117759
ID:
200117759
12.

Regulation of kidney field specification by transcriptional regulation of microRNAs

(Submitter supplied) The transcriptional events driving specification of the kidney field have been well characterized. However, it remains unknown how the initial field size is established, patterned, and proportioned. Lhx1 is a transcription factor expressed in the kidney anlage and is required for specification of the kidney field, but few Lhx1 interacting cofactors or downstream targets have been identified. By tandem-affinity purification, we isolated Furry (FRY), a multifunctional protein that acts as a transcriptional co-repressor of microRNAs. more...
Organism:
Xenopus laevis
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL14834
3 Samples
Download data: XLS
Series
Accession:
GSE100434
ID:
200100434
13.

Enhancer looping protein LDB1 regulates hepatocyte gene expression by cooperating with liver transcription factors

(Submitter supplied) To study LDB1 function in liver cell, gene expression changes and LDB1 binding and H3K27ac modification were detected by RNA-seq and ChIP-seq.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL17021
40 Samples
Download data: BIGWIG, TXT, XLSX
Series
Accession:
GSE179845
ID:
200179845
14.

Genome-wide maps of five major transcription factors in epiblast stem cells

(Submitter supplied) ChIP-seq data of ZIC2, OTX2, SOX2, POU5F1 and POU3F1 in EpiSCs
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
11 Samples
Download data: BED, BW
Series
Accession:
GSE74636
ID:
200074636
15.

Epigenetic Profiling of Cardiac Pacemaker Cells Reveals a Conserved Isl1 Enhancer That Regulates Sinoatrial Node Development and Function

(Submitter supplied) Cardiac pacemaker cells (PCs) in the sinoatrial node (SAN) have a distinct gene expression program that allows them to fire automatically and initiate the heartbeat. Although critical SAN transcription factors, including Isl1, have been identified, the cis-regulatory architecture that governs PC-specific gene expression is not understood, and discrete enhancers required for gene regulation in the SAN have not been identified. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL21103
13 Samples
Download data: BW, TXT
Series
Accession:
GSE148515
ID:
200148515
16.

The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
13 Samples
Download data
Series
Accession:
GSE178166
ID:
200178166
17.

ChIP-seq analysis of OTX2 in hES-RPE cells

(Submitter supplied) OTX2 binding sites were profiled in RPE cells generated from human embryonic stem cells (hES-RPE)
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
4 Samples
Download data: BED
Series
Accession:
GSE178165
ID:
200178165
18.

ChIP-seq analysis of LHX2 in hES-RPE cells

(Submitter supplied) LHX2 binding sites were profiled in RPE cells generated from human embryonic stem cells (hES-RPE)
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
5 Samples
Download data: BED
Series
Accession:
GSE178164
ID:
200178164
19.

RNA-seq analysis of hES-RPE cells in 14d from LHX2 KD and control - non-specific shRNA

(Submitter supplied) RNA-seq analysis was applied in duplicates to hES-RPE cells in 14d: LHX2-KD and control - non-specific shRNA
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
4 Samples
Download data: XLSX
20.

Pax3 cooperates with Ldb1 to direct local chromosome architecture during lineage specification

(Submitter supplied) Chromatin looping allows enhancer-bound regulatory factors to influence transcription. Large domains, referred to as Topologically Associated Domains (TADs), participate in genome organization but the mechanisms underlining interactions within TADs, that actually control gene expression, are largely unknown. Here we report that activation of embryonic myogenesis is associated with establishment of long-range chromatin interactions centered on Pax3-bound loci. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL24247 GPL17021 GPL21626
60 Samples
Download data: BED, HIC
Series
Accession:
GSE126362
ID:
200126362
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