Similar studies for GEO DataSets (Select 200076174) - GEO DataSets

Select item 2000761741.

Cause and consequence of tethering a sub-TAD to different nuclear compartments

(Submitter supplied) Detailed genomic contact maps have revealed that chromosomes are composed of developmentally stable topologically associated domains (TADs) and more flexible sub-TADs. These domains reside in active and inactive nuclear compartments, but cause and consequence of compartmentalization are largely unknown. Here, we combined lacO/lacR binding platforms with allele-specific 4C technologies to track their precise position in the three-dimensional genome upon recruitment of NANOG, SUV39H1 or EZH2. more...

Organism:: Mus musculus

Type:: Other

Platforms:: GPL13112 GPL19057
45 Samples

Download data: WIG

Series

Accession:: GSE76174

ID:: 200076174

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000313542.

The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation

(Submitter supplied) Polycomb group (PcG) proteins form multiprotein complexes, called Polycomb repressive complexes (PRCs). PRC2 contains the PcG proteins EZH2, SUZ12, and EED and represses transcription through methylation of lysine (K) 27 of histone H3 (H3). Suz12 is essential for PRC2 activity and its inactivation results in early lethality of mouse embryos.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE31354

ID:: 200031354

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000738253.

Spatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

4 related Platforms
59 Samples

Download data: BED, CEL, TXT

Series

Accession:: GSE73825

ID:: 200073825

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000738204.

Spatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes [ChIP-Seq]

(Submitter supplied) Trithorax group (TrxG) and Polycomb group (PcG) proteins are two mutually antagonistic chromatin modifying complexes, however, how they together mediate transcriptional counterregulation remains unknown. Genome-wide analysis revealed that binding of Ezh2 and Menin, central members of the PcG and TrxG complexes, respectively, were reciprocally correlated. Moreover, we identified a developmental change in the positioning of Ezh2 and Menin in differentiated T lymphocytes compared to embryonic stem cells. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11002 GPL17021
46 Samples

Download data: BED

Series

Accession:: GSE73820

ID:: 200073820

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000738135.

Spatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes [RNA-Seq]

(Submitter supplied) Trithorax group (TrxG) and Polycomb group (PcG) proteins are two mutually antagonistic chromatin modifying complexes, however, how they together mediate transcriptional counterregulation remains unknown. Genome-wide analysis revealed that binding of Ezh2 and Menin, central members of the PcG and TrxG complexes, respectively, were reciprocally correlated. Moreover, we identified a developmental change in the positioning of Ezh2 and Menin in differentiated T lymphocytes compared to embryonic stem cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18480 GPL17021
10 Samples

Download data: TXT

Series

Accession:: GSE73813

ID:: 200073813

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000727576.

Spatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes [array]

(Submitter supplied) Trithorax group (TrxG) and Polycomb group (PcG) proteins are two mutually antagonistic chromatin modifying complexes, however, how they together mediate transcriptional counterregulation remains unknown. Genome-wide analysis revealed that binding of Ezh2 and Menin, central members of the PcG and TrxG complexes, respectively, were reciprocally correlated. Moreover, we identified a developmental change in the positioning of Ezh2 and Menin in differentiated T lymphocytes compared to embryonic stem cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
3 Samples

Download data: CEL

Series

Accession:: GSE72757

ID:: 200072757

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000510797.

The polycomb protein Ezh2 regulates differentiation and plasticity of CD4 T helper type-1 and type-2 cells [ChIP-seq]

(Submitter supplied) Following antigen encounter by CD4 T cells, polarizing cytokines induce the expression of master regulators that control differentiation. Inactivation of the histone methyltransferase Ezh2 was found to specifically enhance T-helper (Th)1 and Th2 cell differentiation and plasticity. Ezh2 directly bound and facilitated correct expression of Tbx21 and Gata3 in differentiating Th1 and Th2 cells, accompanied by substantial tri-methylation at lysine 27 of histone 3 (H3K27-Me3). more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
6 Samples

Download data: BED

Series

Accession:: GSE51079

ID:: 200051079

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000507298.

The polycomb protein Ezh2 regulates differentiation and plasticity of CD4 T helper type-1 and type-2 cells.

(Submitter supplied) Following antigen encounter by CD4 T cells, polarizing cytokines induce the expression of master regulators that control differentiation. Inactivation of the histone methyltransferase Ezh2 was found to specifically enhance T-helper (Th)1 and Th2 cell differentiation and plasticity. Ezh2 directly bound and facilitated correct expression of Tbx21 and Gata3 in differentiating Th1 and Th2 cells, accompanied by substantial tri-methylation at lysine 27 of histone 3 (H3K27-Me3). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE50729

ID:: 200050729

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000613729.

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

(Submitter supplied) [This SuperSeries is composed of the SubSeries listed below.] Embryogenesis requires the precise activation and repression of many transcriptional regulators. The Polycomb group proteins and the associated H3K27me3 histone mark are essential to maintain the inactive state of many of these genes. Mammalian Hox genes are targets of Polycomb proteins and form local 3D clusters centered on the H3K27me3 mark. more...

Organism:: Mus musculus

Type:: Other; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
36 Samples

Download data: BEDGRAPH, BW

Series

Accession:: GSE61372

ID:: 200061372

PubMed Full text in PMC Similar studies

Select item 20006137110.

4C-seq: Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

(Submitter supplied) Embryogenesis requires the precise activation and repression of many transcriptional regulators. The Polycomb group proteins and the associated H3K27me3 histone mark are essential to maintain the inactive state of many of these genes. Mammalian Hox genes are targets of Polycomb proteins and form local 3D clusters centered on the H3K27me3 mark. More distal contacts have also been described, yet their selectivity, dynamics and relation to other layers of chromatin organization remained elusive. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL13112
32 Samples

Download data: BEDGRAPH, BW

Series

Accession:: GSE61371

ID:: 200061371

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006136511.

ChIP-seq: Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

(Submitter supplied) Embryogenesis requires the precise activation and repression of many transcriptional regulators. The Polycomb group proteins and the associated H3K27me3 histone mark are essential to maintain the inactive state of many of these genes. Mammalian Hox genes are targets of Polycomb proteins and form local 3D clusters centered on the H3K27me3 mark. More distal contacts have also been described, yet their selectivity, dynamics and relation to other layers of chromatin organization remained elusive. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: BW

Series

Accession:: GSE61365

ID:: 200061365

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005534412.

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Other; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL9250
47 Samples

Download data: BEDGRAPH, BW, TXT

Series

Accession:: GSE55344

ID:: 200055344

PubMed Full text in PMC Similar studies

Select item 20005534213.

4C-seq: Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

(Submitter supplied) Hox genes are essential regulators of embryonic development. They are activated in a temporal sequence following their topological order within their genomic clusters. Subsequently, states of activity are fine-tuned and maintained to translate into domains of progressively overlapping gene products. While the mechanisms underlying such temporal and spatial progressions begin to be understood, many of their aspects remain unclear. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL9250
41 Samples

Download data: BEDGRAPH, BW

Series

Accession:: GSE55342

ID:: 200055342

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005495514.

ChIP-seq: Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

(Submitter supplied) Hox genes are essential regulators of embryonic development. They are activated in a temporal sequence following their topological order within their genomic clusters. Subsequently, states of activity are fine-tuned and maintained to translate into domains of progressively overlapping gene products. While the mechanisms underlying such temporal and spatial progressions begin to be understood, many of their aspects remain unclear. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: BW

Series

Accession:: GSE54955

ID:: 200054955

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005495215.

RNA-seq: Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

(Submitter supplied) Hox genes are essential regulators of embryonic development. They are activated in a temporal sequence following their topological order within their genomic clusters. Subsequently, states of activity are fine-tuned and maintained to translate into domains of progressively overlapping gene products. While the mechanisms underlying such temporal and spatial progressions begin to be understood, many of their aspects remain unclear. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: BW, TXT

Series

Accession:: GSE54952

ID:: 200054952

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006805016.

Linker histone H1.2 establishes chromatin comapction and gene silencing through recognition of H3K27me3

(Submitter supplied) Linker histone H1 is a protein component of chromatin and has been linked to chromatin compaction and global gene silencing.It has been sugegsted that H1 plays a significant role, regulating a relatively small number of genes. Here we show that H1.2- a variant of H1 subtype is recruited to chromatin region and is dependent on EZH2-mediated H3K27me3. Therefore a Gene expression array analysis was carried out with H1.2 as well as EZH2 knockout MCF7 cells to confirm the interlationship of H1.2 and EZH2 activity.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
6 Samples

Download data: TXT

Series

Accession:: GSE68050

ID:: 200068050

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008472417.

TADs emerge as a functionally, but not structurally privileged scale in the hierarchical folding of chromosomes

(Submitter supplied) Understanding how regulatory sequences interact in the context of chromosomal architecture is a central challenge in biology. Chromosome conformation capture revealed that mammalian chromosomes possess a rich hierarchy of structural layers, from multi-megabase compartments to sub-megabase topologically associating domains (TADs), and further down to sub-TAD loop domains. TADs appear to act as regulatory microenvironments by constraining and segregating regulatory interactions across discrete chromosomal regions. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: TXT

Series

Accession:: GSE84724

ID:: 200084724

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004161018.

mRNA expression after siRNA-mediated knock down of Enhancer of zeste homolog 2 (Ezh2) in human umbilical vein endothelial cells

(Submitter supplied) mRNA expression after Ezh2 knock down was analyzed to identify genes regulated by Ezh2.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
3 Samples

Download data: TXT

Series

Accession:: GSE41610

ID:: 200041610

Select item 20011447019.

Single-cell DNA replication profiling identifies spatiotemporal developmental dynamics of chromosome organization [scRepli-seq]

(Submitter supplied) In mammals, chromosomes are partitioned into megabase-sized topologically associating domains (TADs). TADs can be in either A (active) or B (inactive) subnuclear compartments, which correspond to early (E) and late (L) replicating timing (RT) domains, respectively. Here, we show that RT changes are tightly correlated with A/B compartment changes during mouse embryonic stem cell (mESC) differentiation. more...