Similar studies for GEO DataSets (Select 200076701) - GEO DataSets

Select item 2000767011.

Gene expression in ischemic, end-stage failing and non-failing human hearts

(Submitter supplied) A goal of this study was to identify and investigate previously unrecognized components of the remodeling process in the progression to heart failure by comparing gene expression in ischemic, failing (F) to non-failing (NF) hearts. These results also were compared to the changes observed in a proteomic analysis of F and NF hearts.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE76701

ID:: 200076701

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000216102.

Gene expression analysis in non-failing and failing myocardium pre and post pulsatile and non-pulsatile VAD support

(Submitter supplied) Mechanical unloading by ventricular assist devices (VAD) leads to significant gene-expression changes often summarized as reverse remodeling. However, little is known on individual transcriptome changes during VAD-support and its relationship to non-failing hearts (NF). In addition no data are available for the transcriptome regulation during non-pulsatile VAD-support. Therefore we analysed the gene-expression patterns of 30 paired samples from VAD-supported (including 8 non-pulsatile VADs) and 8 non-failing control hearts (NF) using the first total human genome-array available. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
68 Samples

Download data: CEL, TXT

Series

Accession:: GSE21610

ID:: 200021610

Select item 2000065803.

Molecular alterations following myocardial infarction in mice

(Submitter supplied) Background and Aims: It is known that inflammatory processes are activated in heart failure, but the regulation of cytokines and their role in the pathogenesis of the disease are not well understood. To address this issue, we have performed microarray analysis of non-infarcted left ventricular tissue from mice at various time-points after myocardial infarction. Methods: Molecular alterations in myocardial tissue were measured 3, 5, 7 and 14 days after induced infarction by using cDNA microarrays. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3386
Platform:: GPL891
20 Samples

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Series

Accession:: GSE6580

ID:: 200006580

Select item 33864.

Heart failure progression model: non-infarcted ventricular tissue

Analysis of non-infarcted left ventricular tissues from animals at various time points up to 14 days following myocardial infarction (MI). MI induced by ligating the left coronary artery. Results provide insight into the molecular pathogenesis of heart failure.

Organism:: Mus musculus

Type:: Expression profiling by array, log2 ratio, 4 time sets

Platform:: GPL891
Series:: GSE6580
20 Samples

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DataSet

Accession:: GDS3386

ID:: 3386

Select item 2000438465.

Expression data from cyclically stretched engineered neonatal rat ventricuar myocyte (NRVM) tissues

(Submitter supplied) Mechanical overload in the heart induces pathological remodeling that typcially leads to heart failure. We sought to build an in vitro model of heart failure by applying cyclic stretch to engineered isotropic (iso) and anisotropic (aniso) NRVM tissues. We used micoarrays to determine the effects of longitudinal and transvserse cyclic stretch on gene expression in engineered NRVM cardiac tissues. We found that cyclic stretch induced up-regulation of several known indicators of heart faliure, independent of the direction of stretch.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6247
51 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE43846

ID:: 200043846

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Select item 2001090976.

Genome-Wide DNA Methylation Encodes Cardiac Transcriptional Reprogramming in Human Ischemic Heart Failure [DNA Methylation]

(Submitter supplied) RNA-sequencing analysis was performed on human ischemic left ventricular tissue obtained from patients with end-stage heart failure, which enriched known targets of the polycomb methyltransferase EZH2 compared to non-ischemic hearts. Combined RNA sequencing and genome-wide DNA methylation analysis revealed a robust gene expression pattern consistent with suppression of oxidative metabolism, induced anaerobic glycolysis, and altered cellular remodeling. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:: GPL13534 GPL16791
22 Samples

Download data: IDAT

Series

Accession:: GSE109097

ID:: 200109097

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Select item 2001090967.

Genome-Wide DNA Methylation Encodes Cardiac Transcriptional Reprogramming in Human Ischemic Heart Failure [DNA Methylation]

(Submitter supplied) Background – Epigenetic alterations are stable modifications to chromatin structure that occur in response to environmental cues such as hypoxia or altered nutrient delivery. DNA methylation is a well-established and dynamic DNA modification that contributes to the regulation of gene expression. In the current study, we test the hypothesize that ischemic heart failure is defined by a distinct signature of DNA methylation that corresponds with altered expression of genes involved in cardiac ventricular dysfunction. more...