Similar studies for GEO DataSets (Select 200084931) - GEO DataSets

(Submitter supplied) We report RNA-Seq experiments of whole eye tissues from C57BL/6J background mice at 1.5 h and 9.0 h after light onset to better understand photoreceptor phagocytosis

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11002
6 Samples

Download data: TXT

Series

Accession:: GSE48974

ID:: 200048974

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000383598.

RNA-Seq of eye tissues from A/J, BALB/c, and C57BL/6 background mice

(Submitter supplied) We report RNA-Seq experiments of whole eye tissues from A/J, BALB/c, and C57BL/6 background mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11002
9 Samples

Download data: TXT

Series

Accession:: GSE38359

ID:: 200038359

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000297529.

RNA-Seq of mouse eye and retina tissues from wild type and Nrl transcription factor knockout mice

(Submitter supplied) The initial aim of this work was to understand the pathophysiology of Enhanced S-cone Syndrome (ESCS) that leads to retinal degeneration. Although ESCS was identified in humans decades ago and since then the causative genes have been elucidated, our understanding of the accompanying retinal degeneration is still poorly understood. Knockout of the Nrl transcription factor in mice produces a retina overpopulated with S-cone like photoreceptors along with absence of rod photoreceptors and recapitulates many of the phenotypic features seen in human ESCS patients. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11002
4 Samples

Download data: TXT

Series

Accession:: GSE29752

ID:: 200029752

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20000533810.

In vivo function of NR2E3 in establishing photoreceptor identity during mammalian retinal development

(Submitter supplied) Rod and cone photoreceptors in mammalian retina are generated from common pool(s) of neuroepithelial progenitors. NRL, CRX and NR2E3 are key transcriptional regulators that control photoreceptor differentiation. Mutations in NR2E3, a rod-specific orphan nuclear receptor, lead to loss of rods, increased density of S-cones, and supernormal S-cone-mediated vision in humans. To better understand its in vivo function, NR2E3 was expressed ectopically in the Nrl-/- retina, where post-mitotic precursors fated to be rods develop into functional S-cones similar to the human NR2E3 disease. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2455
Platform:: GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE5338

ID:: 200005338

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 245511.

Photoreceptor-specific nuclear receptor NR2E3 ectopic expression effect on NRL null retinas

Analysis of 4 week-old neural retinal leucine zipper (NRL) null retinas expressing photoreceptor-specific nuclear receptor (NR2E3) from the cone-rod homeobox (CRX) promoter. NRL, NR2E3, and CRX control photoreceptor differentiation. Results provide insight into the molecular function of NR2E3.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 strain sets

Platform:: GPL1261
Series:: GSE5338
8 Samples

Download data: CEL

DataSet

Accession:: GDS2455

ID:: 2455

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20005920112.

Gene expression changes during retinal development and rod specification.

(Submitter supplied) Photoreceptor disorders are collectively known as retinal degeneration (RD), and include retinitis pigmentosa (RP), cone-rod dystrophy and age related macular degeneration (AMD). These disorders are largely genetic in origin; individual mutations in any one of >200 genes cause RD, making mutation specific therapies prohibitively expensive. A better treatment plan, particularly for late stage disease, may involve stem cell transplants into the photoreceptor or ganglion cell layers of the retina. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
20 Samples

Download data: CEL

Series

Accession:: GSE59201

ID:: 200059201

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000897213.

Expression profiling of the developing and mature Nrl -/- mouse retina (Yoshida et al. 2004, HMG)

(Submitter supplied) The rod photoreceptor-specific neural retina leucine zipper protein Nrl is essential for rod differentiation and plays a critical role in regulating gene expression. In the mouse retina, rods account for 97% of the photoreceptors; however, in the absence of Nrl (Nrl-/-), no rods are present and a concomitant increase in cones is observed. Using mouse GeneChips (Affymetrix), we have generated expression profiles of the wild-type and Nrl-/- retina at three time-points representing distinct stages of photoreceptor differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2936
Platform:: GPL81
24 Samples

Download data: CEL

Series

Accession:: GSE8972

ID:: 200008972

Select item 293614.

Neural retina leucine zipper deficiency effect on retinas: time course

Analysis of retinas of mutants lacking the rod photoreceptor-specific neural retina leucine zipper protein (Nrl), at up to 2 months of age. In the absence of Nrl, rods are missing and cones increase in number. Results provide insight into the differences between the two photoreceptor subtypes.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 age, 2 genotype/variation sets

Platform:: GPL81
Series:: GSE8972
24 Samples

Download data: CEL

DataSet

Accession:: GDS2936

ID:: 2936

Select item 20005850115.

MiRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL13112 GPL6246
42 Samples

Download data: CEL, TXT

Series

Accession:: GSE58501

ID:: 200058501

Select item 20005850016.

MicroRNA expression profile in mouse cone photoreceptors at P60 [miRNA-seq]

(Submitter supplied) The outer segments of cones serve as light detectors for daylight color vision, and their dysfunction leads to human blindness conditions. We show that the cone-specific disruption of DiGeorge Syndrome Critical Region Gene 8 (DGCR8) in adult mice led to the loss of miRNAs and the loss of outer segments, resulting in photoreceptors with significantly reduced light responses. Using next-generation sequencing of RNA from isolated wild type P60 cones, we determine the most highly expressed miRNAs as candidates for controlling outer segment maintenance. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: TXT

Series

Accession:: GSE58500

ID:: 200058500

PubMed Similar studies SRA Run Selector

Select item 20005849817.

Expression data of wild type and C-DGCR8 KO cones at different timepoints [RNA-seq]

(Submitter supplied) We have analyzed gene expression in cone photoreceptors isolated from wild type and C-DGCR8 (DiGeorge Syndrome Critical Region Gene 8) KO mice at five different time points to get a mechanistic inside into the altered molecular pathways after microRNAs depletion.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
20 Samples

Download data: TXT

Series

Accession:: GSE58498

ID:: 200058498

PubMed Similar studies SRA Run Selector

Select item 20005849318.

Expression data of wild type and C-DGCR8 KO cones at different timepoints [array]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
20 Samples

Download data: CEL

Series

Accession:: GSE58493

ID:: 200058493

Select item 20018173719.

Resolving fate bifurcation of photoreceptor precursor in human retinal organoid by single-cell transcriptomics

(Submitter supplied) Cone and rod photoreceptors in human enable daytime color and nighttime dark vision respectively and abnormality in photoreceptor development results in blindness. However, when and how the two photoreceptors are fate-determined during development is largely unknown. Herein, we established a cell atlas for human photoreceptor development, based on single-cell transcriptomic profiling of engineered human retinal organoids engineered to trace the photoreceptor lineages during developmentto monitor the photoreceptor lineages during development. more...