Similar studies for GEO DataSets (Select 200085011) - GEO DataSets

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Items: 20

Select item 2000850111.

CRISPRi-based genome-scale identification of functional long non-coding RNA loci in human cells

(Submitter supplied) The human genome produces thousands of long non-coding RNAs (lncRNAs) – transcripts >200 nucleotides long that do not encode proteins. While critical roles in normal biology and disease have been revealed for a subset of lncRNAs, the function of the vast majority remains untested. Here, we developed a CRISPR interference (CRISPRi) platform targeting 16,401 lncRNA loci in 7 diverse cell lines including 6 transformed cell lines and human induced pluripotent stem cells (iPSCs). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL20301
112 Samples

Download data: TXT, ZIP

Series

Accession:: GSE85011

ID:: 200085011

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001416152.

An MXD1-derived repressor peptide identifies non-coding mediators of MYC-driven cell proliferation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL16791
35 Samples

Download data: TXT

Series

Accession:: GSE141615

ID:: 200141615

PubMed Full text in PMC Similar studies

Select item 2001414913.

An MXD1-derived repressor peptide identifies non-coding mediators of MYC-driven cell proliferation [Amplicon-seq]

(Submitter supplied) MYC controls the transcription of large numbers of long non-coding RNAs. Since MYC is a ubiquitous oncoprotein, some of these long non-coding RNAs (lncRNAs) probably play a significant role in cancer. We applied CRISPRi to the identification of MYC-regulated lncRNAs that are required for MYC-driven cell proliferation in the P493-6 and RAMOS human lymphoid cell lines. We identified 320 non-coding loci that play a positive role in cell growth. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16791
33 Samples

Download data: TXT, XLSX

Series

Accession:: GSE141491

ID:: 200141491

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001414824.

An MXD1-derived repressor peptide identifies non-coding mediators of MYC-driven cell proliferation [RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
2 Samples

Download data: TXT, XLSX

Series

Accession:: GSE141482

ID:: 200141482

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001181905.

Transcriptional response to PORCN inhibition using an in vitro model of RNF43 mutant pancreatic adenocarcinoma (HPAF-II)

(Submitter supplied) SRP136961 - PRJNA448457 - RNA-seq of response to PORCN inhibition, using ETC-159, in vitro of RNF43 mutant pancreatic adenocarcinoma (HPAF-II).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
12 Samples

Download data: TXT

Series

Accession:: GSE118190

ID:: 200118190

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001181796.

Transcriptional response to PORCN inhibition using a subcutaneous model of RNF43 mutant pancreatic adenocarcinoma (HPAF-II)

(Submitter supplied) SRP136970 - PRJNA448481 - RNA-seq of response to PORCN inhibition, using ETC-159,in a subcutanenous model of RNF43 mutant pancreatic adenocarcinoma (HPAF-II).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
10 Samples

Download data: TXT

Series

Accession:: GSE118179

ID:: 200118179

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001180417.

Transcriptional response to PORCN inhibition using an orthotopic model of RNF43 mutant pancreatic adenocarcinoma (HPAF-II)

(Submitter supplied) Timecourse RNA-seq of response to PORCN inhibition, using ETC-159, in an orthotopic model of RNF43 mutant pancreatic adenocarcinoma (HPAF-II).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
43 Samples

Download data: TXT

Series

Accession:: GSE118041

ID:: 200118041

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001092718.

Competitive RNA Pair Controls Gastric Cancer Metastasis by Regulating EphrinA1 Translation

(Submitter supplied) EphrinA1 overexpression-induced gene signature was significantly enriched in the cells with high expression of GMAN

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
3 Samples

Download data: TXT

Series

Accession:: GSE109271

ID:: 200109271

Select item 2001068159.

Competitive RNA Pair Controls Gastric Cancer Metastasis

(Submitter supplied) To explor the role of lncRNAs in gastric cancer progression, we performed a microarray analysis to systematically screen the differential expression of lncRNAs between six human gastric cancer tissues and their matched non-tumor tissues

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL11269
12 Samples

Download data: PAIR

Series

Accession:: GSE106815

ID:: 200106815

Select item 20010496010.

Competitive RNA Pair Controls Gastric Cancer Metastasis by Regulating EphrinA1 mRNA Translation

(Submitter supplied) EphrinA1 silencing-induced gene signature was significantly enriched in GMAN-depleted cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
3 Samples

Download data: TXT

Series

Accession:: GSE104960

ID:: 200104960

Select item 20007698011.

iPSC RNA-seq upon CRISPRn or CRISPRi manipulation

(Submitter supplied) Assess the on- and off-target effects of dox-inducible CRISPR/Cas9 and CRISPRi constructs in a human iPS cell line.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
16 Samples

Download data: TSV

Series

Accession:: GSE76980

ID:: 200076980

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008361912.

HI-LNC RNA knockdown in EndoC-betaH1 cell using lentiviral ami-aRNAs

(Submitter supplied) We have previously identified hundreds of human islet lncRNAs. Here we functionally characterise 12 such lncRNAs in EndoC-betaH1 cells through loss of function studies. Our results suggest that a number of them display transcriptional phenotypes.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
84 Samples

Download data: CEL, CHP

Series

Accession:: GSE83619

ID:: 200083619

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008579813.

Local regulation of gene expression by lncRNA promoters, transcription, and splicing

(Submitter supplied) Mammalian genomes are pervasively transcribed to produce thousands of spliced long noncoding RNAs (lncRNAs), whose functions remain poorly understood. Because recent evidence has implicated several specific lncRNA loci in the local regulation of gene expression, we sought to determine whether such local regulation is a property of many lncRNA loci. We used genetic manipulations to dissect 12 genomic loci that produce lncRNAs and found that 5 of these loci influence the expression of a neighboring gene in cis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL17021
462 Samples

Download data: BED, TDF

Series

Accession:: GSE85798

ID:: 200085798

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008026214.

RNA-sequencing of subcellular fractions in mouse embryonic stem cells

(Submitter supplied) We examined the subcellular localization of long noncoding RNAs (lncRNAs) in mouse embryonic stem cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: BIGWIG

Series

Accession:: GSE80262

ID:: 200080262

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011660515.

Combined RNA-seq and RAT-seq mapping of long noncoding RNAs in pluripotent reprogramming

(Submitter supplied) RNA transcriptome sequencing (RNA-Seq) and RNA reverse transcription-associated trap sequencing (RAT-Seq) were usded to map long noncoding RNA (lncRNAs) in reprogramming of fibroblasts into pluripotency

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: BEDGRAPH

Series

Accession:: GSE116605

ID:: 200116605

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010176516.

Genome-wide target profiling of pluripotency-associated long noncoding RNAs by RAT-Seq

(Submitter supplied) Using RNA reverse transcription-associated trap sequencing (RAT-Seq), we profiled the genome-wide binding gene targets for pluripotency-associated long noncoding RNAs (lncRNAs), including Platr10 (Osclr8), Oeblr20, Oplr16, Palr35, Palr34, Peln1, and Peln4. These datasets will help study the mechanisms underlying the role of lncRNAs in the establishment and maintenance of pluripotency.

Organism:: Mus musculus

Type:: Other

Platform:: GPL17021
8 Samples

Download data: BEDGRAPH

Series

Accession:: GSE101765

ID:: 200101765

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008782417.

Systematic identification and comparison of expressed profiles of lncRNAs and circRNAs in male and female germline stem cells

(Submitter supplied) Male and female germline stem cells are critical for passing genetic information from generation to generation. Accumulating evidences indicate that long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) play important roles in self-renewal and differentiation of germline stem cells. However, the mechanisms remain largely unknown. In this study, we explored the mRNAs, lncRNAs and circRNAs expression profiles of male and female germline stem cells through high-throughput sequencing.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: XLSX

Series

Accession:: GSE87824

ID:: 200087824

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006675618.

CRISPR Display: A modular method for locus-specific targeting of long noncoding RNAs and synthetic RNA devices in vivo

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
17 Samples

Download data

Series

Accession:: GSE66756

ID:: 200066756

PubMed Full text in PMC Similar studies

Select item 20006675519.

CRISPR Display: A modular method for locus-specific targeting of long noncoding RNAs and synthetic RNA devices in vivo [RNA-Seq]

(Submitter supplied) Noncoding RNAs (ncRNAs) comprise an important class of natural regulators that mediate a vast array of biological processes, including the modulation of chromatin architecture. Moreover, artificial ncRNAs have revealed that the functional capabilities of RNA are extremely broad. To further investigate and harness these capabilities, we developed CRISPR-Display ("CRISP-Disp"), a targeted localization strategy that uses Cas9 to deploy large RNA cargos to specific DNA loci. more...