Similar studies for GEO DataSets (Select 200102421) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Links from GEO DataSets

Items: 11

Select item 2001024211.

DNA Methylation-dependent regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice.

(Submitter supplied) Global DNA hypomethylation in CD4+ cells in SLE patients was suggested to play a key role in the pathogenesis. To identify new methylation-sensitive genes, we integrated genome-wide DNA methylation and mRNA profiling in CD4+ cells of MRL/lpr (MRL) and C57BL6/J (B6) mice. We identified Ctse, in which 13 methyl-CpGs within 583 bp region of intron 1 were hypomethylated, and mRNA upregulated in MRL compared with B6 mice. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL13112 GPL17021
4 Samples

Download data: XLSX

Series

Accession:: GSE102421

ID:: 200102421

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000212202.

miRNAs expression in the splenic CD4+ T cells and B cells isolated from MRL/lpr mice at 5 and 16 weeks of age

(Submitter supplied) To identify any differentially expressed miRNAs in the CD4+ T cells of lupus. MicroRNAs (miRNAs) have been implicated as fine-tuning regulators controlling diverse biological processes at the level of posttranscriptional repression. Dysregulation of miRNAs has been described in various disease states, including human lupus. By using high-throughput microRNA profiling analysis, we identified that two miRNAs (miR-21 and miR-148a) overexpressed in CD4+ T cells from both lupus patients and lupus-prone MRL/lpr mice,which promote cell hypomethylation by repressing DNA methyltransferase 1 (DNMT1) expression.

Organism:: Mus musculus

Type:: Other

Platform:: GPL10354
8 Samples

Download data

Series

Accession:: GSE21220

ID:: 200021220

Select item 2000872193.

Down-regulation of miR-200a-3p, targeting C-terminal binding protein-2 (CtBP2), is involved in hypoproduction of IL-2 in SLE-derived T cells

(Submitter supplied) Systemic lupus erythematosus (SLE) damages multiple organs by producing various autoantibodies. Insufficient interleukin-2 (IL-2) production causes decreased regulatory T cells and permits expansion of autoreactive T cells in the development of SLE. We here show that decreased miR-200a-3p causes IL-2 hypoproduction through directly recruiting ZEB1 or ZEB2 and CtBP2 (ZEB1/ZEB2-CtBP2) complex in SLE T cells. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: XLSX

Series

Accession:: GSE87219

ID:: 200087219

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002429554.

Egr2 deletion in autoimmune-prone C57BL6/lpr mice suppresses the expression of methylation-sensitive Dlk1-Dio3 cluster microRNAs

(Submitter supplied) Our previous study demonstrated a significant upregulation of a large set of miRNAs at the genomic imprinted Dlk1-Dio3 locus in lymphocytes of diverse murine lupus-prone strains. The upregulation of Dlk1-Dio3 miRNAs in lupus-prone mice is correlated with the global DNA hypomethylation. In this study, by performing genome-wide DNA methylation analysis, we reported that Dlk1-Dio3 genomic region in CD4+ T cells of MRL/lpr mice was hypomethylated, further linking hypomethylation to the increased expression of Dlk1-Dio3 miRNAs in lupus. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platforms:: GPL24247 GPL21103
10 Samples

Download data: XLSX

Series

Accession:: GSE242955

ID:: 200242955

PubMed Full text in PMC Similar studies

Select item 2000592505.

DNA Methylation Analysis of Systemic Lupus Erythematosus

(Submitter supplied) This study performed Illumina Methylation450 analysis of CD4+ T-cells, CD19+ B-cells and CD14+ Monocytes from lupus patients and controls. A validation cohort was further analyzed with the same platform using CD4+ T-cells, CD45RO-CD45RA+ naive T-cells, CD45RO+CD45RA- memory T-cells, and CD25+CD127- regulatory T-cells.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
434 Samples

Download data: TXT

Series

Accession:: GSE59250

ID:: 200059250

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000822216.

Whole genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL13534 GPL10558
110 Samples

Download data

Series

Accession:: GSE82221

ID:: 200082221

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000816227.

Whole genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus [expression]

(Submitter supplied) Our study has demonstrated that significant number of differential genes in SLE was involved in IFN, TLR signaling pathways and inflammatory cytokines. The enrichment of differential genes has been associated with aberrant DNA methylation, which may be relevant to the pathogenesis of SLE. Our observations laid the groundwork for further diagnostic and mechanistic studies of SLE and LN.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
55 Samples

Download data: TXT

Series

Accession:: GSE81622

ID:: 200081622

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000278958.

Global DNA methylation profiling of CD4+ T cells from patients with systemic lupus erythematosus

(Submitter supplied) Systemic lupus erythematosus (SLE) is a chronic-relapsing autoimmune disease of incompletely understood etiology. Recent evidence strongly supports an epigenetic contribution to the pathogenesis of lupus. To understand the extent and nature of dysregulated DNA methylation in lupus T cells, we performed a genome-wide DNA methylation study in CD4+ T cells from 12 lupus patients and 12 normal healthy controls. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
23 Samples

Download data: TXT

Series

Accession:: GSE27895

ID:: 200027895

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001068079.

DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL17021 GPL19057
24 Samples

Download data: COV

Series

Accession:: GSE106807

ID:: 200106807

PubMed Full text in PMC Similar studies

Select item 20010680610.

DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice

(Submitter supplied) Lung CD4+ T cell responses may determine outcomes in pediatric pnuemonia. We therefore sought to define the transcriptional response and underlying DNA methyaltion landscape of lung CD4+ T cells by treating neonatal (~5 days of age) and juvenile (~15 days of age) mice with 2.8 million CFUs of E. coli or PBS (control) by aspiration. 48 hours later, lung CD4+ T cells were isolated by magnetic bead pre-enrichment and fluorescence-activated cell sorting for RNA-sequencing (RNA-seq) and modified reduced representation bisulfite sequencing (mRRBS).