Similar studies for GEO DataSets (Select 200102491) - GEO DataSets

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Items: 16

Select item 2001024911.

c-Maf-dependent transcripts in effector Tregs from Peyer's patches

(Submitter supplied) We identify c-Maf as an essential factor regulating adoption of RORgamma t+ and T follicular regulatory phenotypes in effector Tregs. Differential expression analysis demonstrates reduced signatures of both ROR gamma t+ Tregs and T follicular regulatory cells following regulatory T cell-specific c-Maf deletion.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: TXT

Series

Accession:: GSE102491

ID:: 200102491

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001033192.

Generation of RORγt+ antigen-specific T regulatory 17 (Tr17) cells from Foxp3+ precursors in autoimmunity

(Submitter supplied) Th17 cells are potent mediators in autoimmune diseases and RORγt is required for their development. Recent studies have shown that RORγt+ Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study, we report that RORγt+ Treg cells were also found in lymph nodes following immunization. Not only distinct from intestinal RORγt+ Treg in their transcriptomes, peripheral RORγt+ Treg cells were derived from Foxp3+ thymic Treg cells, in an antigen-specific manner. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL14602
5 Samples

Download data: TXT

Series

Accession:: GSE103319

ID:: 200103319

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000523373.

mRNA expression in CD4+ CD25+ GITR+ regulatory T cells from WT and Bach2 KO mice

(Submitter supplied) Bach2 regulates homeostasis of foxp3+ regulatory T cells and protects against fatal lung disease in mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
2 Samples

Download data: TXT

Series

Accession:: GSE52337

ID:: 200052337

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001063964.

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis

(Submitter supplied) Foxp3+ regulatory T (Treg) cells are essential for immunological tolerance and homeostasis. In peripheral tissues, Treg cells acquire enhanced suppressive functions and co-opt distinct transcriptional modules, allowing context and tissue-dependent immune regulation. Here we show that the transcription factor c-Maf was highly expressed by effector Treg cells and controlled their IL-10 production. In the intestine, c-Maf was required for the differentiation of RORgt+ microbiota-dependent Treg cells, and restricted their production of inflammatory cytokines. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
10 Samples

Download data: TXT

Series

Accession:: GSE106396

ID:: 200106396

PubMed Similar studies SRA Run Selector

Select item 2001373225.

c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL21103 GPL19057
47 Samples

Download data: BW, NARROWPEAK, TXT

Series

Accession:: GSE137322

ID:: 200137322

PubMed Full text in PMC Similar studies

Select item 2001373216.

c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program [RNA-seq]

(Submitter supplied) The transcription factor c-Maf is an essential regulator of group 3 ILC homeostasis and effector plasticity. c-Maf limits acquisition of the type 1 program and conversion to the ILC1 fate through restraint of T-bet expression and function.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
18 Samples

Download data: TXT

Series

Accession:: GSE137321

ID:: 200137321

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001373207.

c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program [CUT&RUN]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
11 Samples

Download data: BW

Series

Accession:: GSE137320

ID:: 200137320

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001373198.

c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program [ATAC-seq]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
18 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE137319

ID:: 200137319

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000938569.

RNA-seq analysis of transcriptomes of thymus derived tTreg cells and the exFoxp3 precursor cells

(Submitter supplied) To determine the phenotype of the precursor of exFoxp3 cells and find the signals that affect the stability of tTreg cells, we analysis the transcriptomes of epigenetic stable thymus derived tTreg cells and the exFoxp3 precursor cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: TXT

Series

Accession:: GSE93856

ID:: 200093856

PubMed Similar studies SRA Run Selector

Select item 20006899110.

FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3

(Submitter supplied) Treg dysfunction is associated with a variety of inflammatory diseases. Treg populations are defined by expression of the oligomeric transcription factor FOXP3 and inability to produce IL-2, a cytokine required for T cell maintenance and survival. FOXP3 activity is regulated post-translationally by histone/protein acetyltransferases and histone/protein deacetylases (HDACs). Here, we determined that HDAC3 mediates both the development and function of the two main Treg subsets, thymus-derived Tregs and induced Tregs (iTregs). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
6 Samples

Download data: CEL

Series

Accession:: GSE68991

ID:: 200068991

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001960111.

Gene expression profiling in murine Smad-deficient CD4+ T cells stimulated with TGF-b

(Submitter supplied) TGF-b is an important pleiotropic cytokine with potent immunoregulatory properties. Although many previous reports have been proposed for the immunoregulatory functions of TGF-b on T cells, such as the suppression of cell proliferation, cytokine production and cytokine signaling, as well as the induction of apoptosis, it is not well elucidated whether the each effect of TGF-b on T cells is dependent on Smad signaling or Smad-independent other signaling pathways. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE19601

ID:: 200019601

Select item 20015725912.

DDX5 RNA interactome in cultured T cells

(Submitter supplied) RAR-related orphan receptor gamma (ROR t)-expressing regulatory T (ROR t+ Treg) cells play pivotal roles in preventing T cell hyperactivation and maintaining tissue homeostasis, in part, by secreting the anti-inflammation cytokine interleukin 10 (IL-10). Here, we report that Hypoxia Induced Factor 1a (HIF1alpha) is the master transcription factor for *Il10* in ROR t+ Tregs. Interestingly, this critical anti-inflammatory pathway is negatively regulated by an RNA-binding protein DEAD box helicase 5 (DDX5). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL21103
4 Samples

Download data: BW, TXT

Series

Accession:: GSE157259

ID:: 200157259

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010646413.

The transcription factor c-Maf is a positive regulator of IL-10 with context-specific roles in CD4+ T cell effector function and in vivo consequences

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
150 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE106464

ID:: 200106464

PubMed Full text in PMC Similar studies

Select item 20010646314.

The transcription factor c-Maf is a positive regulator of IL-10 with context-specific roles in CD4+ T cell effector function and in vivo consequences [RNA-seq in vitro]

(Submitter supplied) CD4+ T cells differentiate into distinct subsets which produce unique patterns of cytokines to eradicate pathogens, alongside IL-10 which controls immune pathology. How Il10 expression is regulated alongside the subset-specific cytokines is unclear. Using transcriptional and epigenomic profiling of CD4+ T cells from TH1 (malaria), TH2 (allergy) and TH17 (autoimmunity) disease models, we show here that c-Maf, identified as the top candidate regulator of IL-10, directly induces IL-10 across all CD4+ T cell subsets, controlling pathology in TH1 and TH2-type responses. more...