Similar studies for GEO DataSets (Select 200107638) - GEO DataSets

Select item 2001076381.

Contribution of differential cell-specific methylation to schizophrenia [RNA-seq]

(Submitter supplied) To address the heterogeneity of gene regulation and expression in cell types of a brain region with strong evidence for relevance to schizophrenia, we carried out whole genome methylation and expression analyses using post-mortem brain tissue from BA46 that underwent fluorescence-activated nuclei sorting (FANS). Importantly, we used whole genome bisulfite sequencing (WGBS) for methylation quantification to have an unbiased assessment of epigenetic modifications associated with schizophrenia, and additionally carried out whole genome sequencing (WGS) of the brain samples to account for genetic background differences. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
96 Samples

Download data: TXT

Series

Accession:: GSE107638

ID:: 200107638

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Select item 2001239362.

Accelerated evolution of oligodendrocytes in human brain

(Submitter supplied) Recent discussions of human brain evolution have largely focused on increased neuron numbers and changes in their connectivity and expression. However, it is increasingly appreciated that oligodendrocytes play important roles in cognitive function and disease. Whether both cell types follow distinctive evolutionary trajectories is not known. We examined the transcriptomes of neurons and oligodendrocytes in the frontal cortex of humans, chimpanzees, and rhesus macaques. more...

Organism:: Pan troglodytes; Macaca mulatta; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL21121 GPL21120
95 Samples

Download data: TXT

Series

Accession:: GSE123936

ID:: 200123936

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Select item 2001080663.

Contribution of differential cell-specific methylation to schizophrenia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other

Platforms:: GPL18573 GPL20795 GPL16791
245 Samples

Download data: TXT

Series

Accession:: GSE108066

ID:: 200108066

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Select item 2001080654.

Genome-wide sequencing of schizophrenia and control individuals [WGS]

(Submitter supplied) We carried out whole genome sequencing of 29 schizophrenia patients and 25 control individuals

Organism:: Homo sapiens

Type:: Other

Platforms:: GPL20795 GPL16791
54 Samples

Download data: BED, BIM, FAM

Series

Accession:: GSE108065

ID:: 200108065

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Select item 2001077295.

Genome-wide profiling at single-nucleotide resolution of brain cell types in schizophrenia [WGBS]

(Submitter supplied) We carried out cell-type specific whole genome bisulfite sequencing from BA46 that underwent fluorescence-activated nuclei sorting (FANS).

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platforms:: GPL16791 GPL20795
95 Samples

Download data: TXT

Series

Accession:: GSE107729

ID:: 200107729

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Select item 2000372026.

Evolutionary Significance of DNA Methylation in Human and Chimpanzee Brains

(Submitter supplied) We compared the genome-wide patterns of DNA methylation in the brains of humans to those of our closest evolutionary relative, chimpanzees, using base-pair resolution whole-genome methylation maps of the prefrontal cortex. Our data reveal that the prefrontal cortex is the most heavily methylated among the human tissues examined so far. Nevertheless, hundreds of genes exhibit dramatically reduced levels of promoter DNA methylation in the human brain relative to the chimpanzee brain. more...

Organism:: Homo sapiens; Pan troglodytes

Type:: Methylation profiling by high throughput sequencing

Platforms:: GPL15434 GPL15433 GPL9115
6 Samples

Download data: GFF

Series

Accession:: GSE37202

ID:: 200037202

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Select item 2000335887.

Human-specific patterns of gene expression in the brain

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Macaca mulatta; Homo sapiens; Pan troglodytes

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

5 related Platforms
92 Samples

Download data: CEL, TXT

Series

Accession:: GSE33588

ID:: 200033588

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Select item 2000335878.

Human-specific patterns of gene expression in the brain (RNA-Seq)

(Submitter supplied) We identified human-specific gene expression patterns in the brain by comparing expression with chimpanzee and rhesus macaque.

Organism:: Pan troglodytes; Macaca mulatta; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL9378 GPL9115 GPL9160
44 Samples

Download data: TXT

Series

Accession:: GSE33587

ID:: 200033587

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Select item 2000330109.

Human-specific patterns of gene expression in the brain (Arrays)

(Submitter supplied) We identified human-specific gene expression patterns in the brain by comparing expression with chimpanzee and rhesus macaque

Organism:: Pan troglodytes; Homo sapiens; Macaca mulatta

Type:: Expression profiling by array

Platforms:: GPL570 GPL3535
48 Samples

Download data: CEL, TXT

Series

Accession:: GSE33010

ID:: 200033010

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Select item 20015893410.

Evolution of regulatory signatures in primate cortical neurons at cell-type resolution

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Macaca mulatta; Pan troglodytes

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19129 GPL19148
46 Samples

Download data: BW

Series

Accession:: GSE158934

ID:: 200158934

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Select item 20015893211.

Evolution of regulatory signatures in primate cortical neurons at cell-type resolution [RNA-Seq]

(Submitter supplied) The human cerebral cortex contains many cell types that likely underwent independent functional changes during evolution. However, cell-type–specific regulatory landscapes in the cortex re- main largely unexplored. Here we report epigenomic and tran- scriptomic analyses of the two main cortical neuronal subtypes, glutamatergic projection neurons and GABAergic interneurons, in human, chimpanzee, and rhesus macaque. more...

Organism:: Macaca mulatta; Pan troglodytes

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19129 GPL19148
14 Samples

Download data: TXT, XLSX

Series

Accession:: GSE158932

ID:: 200158932

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Select item 20015893112.

Evolution of regulatory signatures in primate cortical neurons at cell-type resolution [ChIP-Seq]

(Submitter supplied) The human cerebral cortex contains many cell types that likely underwent independent functional changes during evolution. However, cell-type–specific regulatory landscapes in the cortex re- main largely unexplored. Here we report epigenomic and tran- scriptomic analyses of the two main cortical neuronal subtypes, glutamatergic projection neurons and GABAergic interneurons, in human, chimpanzee, and rhesus macaque. more...

Organism:: Pan troglodytes; Macaca mulatta

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19129 GPL19148
32 Samples

Download data: BW, XLSX

Series

Accession:: GSE158931

ID:: 200158931

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Select item 20009661513.

Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL16791 GPL20301
114 Samples

Download data

Series

Accession:: GSE96615

ID:: 200096615

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Select item 20009661414.

Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability [ATAC-Seq]

(Submitter supplied) We analyzed differential methylation (via WGBS) between four distinct human brain regions (NAcc-nucleus accumbens, BA9-dorsolateral prefrontal cortex, BA24-anterior cingulate cortex, and HC-hippocampus) in both sorted nuclei and intact tissues. We isolated neuronal and non-neuronal (glial) nuclei from the same six individuals for each tissue via FACS using the neuronal marker, NeuN. Additionally, we performed WGBS from non-sorted tissues from these same brain regions in a total of 12 individuals (BA9 n = 9; BA24 n = 5; HC n = 6; NAcc n = 7). more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
22 Samples

Download data: TXT

Series

Accession:: GSE96614

ID:: 200096614

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Select item 20009661315.

Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability [RNA-Seq]

(Submitter supplied) We analyzed differential methylation (via WGBS) between four distinct human brain regions (NAcc-nucleus accumbens, BA9-dorsolateral prefrontal cortex, BA24-anterior cingulate cortex, and HC-hippocampus) in both sorted nuclei and intact tissues. We isolated neuronal and non-neuronal (glial) nuclei from the same six individuals for each tissue via FACS using the neuronal marker, NeuN. Additionally, we performed WGBS from non-sorted tissues from these same brain regions in a total of 12 individuals (BA9 n = 9; BA24 n = 5; HC n = 6; NAcc n = 7). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
20 Samples

Download data: TXT

Series

Accession:: GSE96613

ID:: 200096613

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Select item 20009661216.

Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability [Bisulfite-Seq]

(Submitter supplied) We analyzed differential methylation (via WGBS) between four distinct human brain regions (NAcc-nucleus accumbens, BA9-dorsolateral prefrontal cortex, BA24-anterior cingulate cortex, and HC-hippocampus) in both sorted nuclei and intact tissues. We isolated neuronal and non-neuronal (glial) nuclei from the same six individuals for each tissue via FACS using the neuronal marker, NeuN. Additionally, we performed WGBS from non-sorted tissues from these same brain regions in a total of 12 individuals (BA9 n = 9; BA24 n = 5; HC n = 6; NAcc n = 7). more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL16791
72 Samples

Download data: TXT

Series

Accession:: GSE96612

ID:: 200096612

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Select item 20005888517.

Methylomic trajectories across human fetal brain development

(Submitter supplied) Dynamic changes to the epigenome mediate key neurobiological and cognitive processes in the central nervous system, and also play a role in transcriptional regulation during brain development. Although the importance of DNA methylation in brain development is highlighted by the neurodevelopmental deficits associated with mutations in genes including methyl-CpG binding protein 2 (MECP2), our knowledge about the specific methylomic trajectories associated with human neurodevelopment is extremely limited. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
179 Samples

Download data: TXT

Series

Accession:: GSE58885

ID:: 200058885

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Select item 20006143118.

Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.

(Submitter supplied) Background: Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances in early brain development, and there is mounting evidence to support a role for developmentally-regulated epigenetic variation in the molecular etiology of the disorder. Here, we describe a systematic study of schizophrenia-associated methylomic variation in the adult brain and its relationship to changes in DNA methylation across human fetal brain development. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
87 Samples

Download data: CSV, TXT

Series

Accession:: GSE61431

ID:: 200061431

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Select item 20006138019.

Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.

(Submitter supplied) Background: Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances in early brain development, and there is mounting evidence to support a role for developmentally-regulated epigenetic variation in the molecular etiology of the disorder. Here, we describe a systematic study of schizophrenia-associated methylomic variation in the adult brain and its relationship to changes in DNA methylation across human fetal brain development. more...