Similar studies for GEO DataSets (Select 200109294) - GEO DataSets

(Submitter supplied) Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we show that the differential expression between the twins is organized in domains along all chromosomes that are either up- or downregulated. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
2 Samples

Download data: TXT

Series

Accession:: GSE55506

ID:: 200055506

PubMed Similar studies SRA Run Selector

Select item 2000555056.

Domains of genomewide gene expression dysregulation in Down syndrome [RRBS]

(Submitter supplied) Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we show that the differential expression between the twins is organized in domains along all chromosomes that are either up- or downregulated. more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL11154
2 Samples

Download data: TXT

Series

Accession:: GSE55505

ID:: 200055505

PubMed Similar studies SRA Run Selector

Select item 2000555047.

Domains of genomewide gene expression dysregulation in Down syndrome [RNA-seq]

(Submitter supplied) Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we show that the differential expression between the twins is organized in domains along all chromosomes that are either up- or downregulated. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL11154 GPL16791
30 Samples

Download data: TXT

Series

Accession:: GSE55504

ID:: 200055504

PubMed Similar studies SRA Run Selector

Select item 2000554268.

Domains of genomewide gene expression dysregulation in Down syndrome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Methylation profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

4 related Platforms
42 Samples

Download data: BW, PAIR, TXT

Series

Accession:: GSE55426

ID:: 200055426

Select item 2000554259.

Domains of genomewide gene expression dysregulation in Down syndrome [Dnase HS mapping]

(Submitter supplied) Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we show that the differential expression between the twins is organized in domains along all chromosomes that are either up- or downregulated. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: BW

Series

Accession:: GSE55425

ID:: 200055425

PubMed Similar studies SRA Run Selector

Select item 20005528910.

Domains of genomewide gene expression dysregulation in Down syndrome [array]

(Submitter supplied) Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we show that the differential expression between the twins is organized in domains along all chromosomes that are either up- or downregulated. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL10559
4 Samples

Download data: PAIR, TXT

Series

Accession:: GSE55289

ID:: 200055289

Select item 20006807411.

Lentiviral vector-based microRNA sponges identifies miR-155 and miR-802 target genes in the hippocampus of Ts65Dn mice

(Submitter supplied) A major challenge in Down syndrome (DS) is to understand how the extra-dose of functional chromosome 21 (HSA21) genetic elements can impact on the tissue-specific transcriptome to contribute to phenotypic alterations. MiRNAs are post-transcriptional modulators with genome-wide regulatory effects. Five microRNAs have been identified in HSA21 that are present in triple copy in DS individuals. Interestingly, in the Ts65Dn mouse model of DS two of these miRNAs, miR-155 and miR-802, are also triplicated resulting in its overexpression. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
16 Samples

Download data: TXT

Series

Accession:: GSE68074

ID:: 200068074

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20023979812.

Effect of Dyrk1a inhibition on the transcriptome of embryonic hearts from the Dp1Tyb mouse model of Down syndrome using bulk RNAseq

(Submitter supplied) Embryos from the Dp1Tyb mouse model for Down syndrome (DS) present with congenital heart defects similar to the heart defects seen in humans with DS. We found that genetically reducing the copy number of the Dyrk1a gene (one of the genes in 3 copies in DS) from 3 to 2, normalised some of the transcriptomic changes in Dp1Tyb embryonic hearts and rescued congenital heart defects. Here we treated pregnant mice carrying Dp1Tyb and wild-type (WT) embryos with a Dyrk1a pharmacological inhibitor (Leucettinib-21 or L21) or an inactive isomer (Iso-L21) to study the effect of L21 on the transcriptome of Dp1Tyb and WT embryonic hearts.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
20 Samples

Download data: RESULTS

Series

Accession:: GSE239798

ID:: 200239798

PubMed Full text in PMC Similar studies

Select item 20019644713.

Down Syndrome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing

4 related Platforms
75 Samples

Download data: RESULTS, TAR

Series

Accession:: GSE196447

ID:: 200196447

PubMed Full text in PMC Similar studies

Select item 20019644614.

Dyrk1a dosage effects on the transcriptome of embryonic hearts from the Dp1Tyb mouse model of Down syndrome using scRNAseq

(Submitter supplied) We performed single cell RNAseq on whole hearts from E13.5 Dp1Tyb embryos and from wild-type littermates, as well as hearts from E13.5 Dp1TybDyrk1a+/+/- embryos and wild-type littermates. We identified 14 clusters which were assigned to individual cell types based on expression of marker genes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
5 Samples

Download data: TAR

Series

Accession:: GSE196446

ID:: 200196446

PubMed Full text in PMC Similar studies

Select item 20019644515.

Dyrk1a dosage effects on the transcriptome of embryonic hearts from the Dp1Tyb mouse model of Down syndrome using bulk RNAseq

(Submitter supplied) We performed bulk RNAseq on whole hearts from E13.5 Dp1Tyb embryos and from wild-type littermates, as well as hearts from E13.5 Dp1TybDyrk1a+/+/- embryos and wild-type littermates. Analysis showed the expected increased expression of the Hsa21-orthologous genes on Mmu16 that are present in 3 copies. Gene set enrichment analysis identified pathways that are altered in Dp1Tyb hearts. Some of these changes were dependent on 3 copies of Dyrk1a.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
20 Samples

Download data: TXT

Series

Accession:: GSE196445

ID:: 200196445

PubMed Full text in PMC Similar studies

Select item 20019644416.

Transcriptomic changes in embryonic hearts from Dp3Tyb and Ts1Rhr mouse models of Down Syndrome

(Submitter supplied) We performed bulk RNAseq on whole hearts from E13.5 Dp3Tyb embryos and from wild-type littermates, as well as hearts from E13.5 Ts1Rhr embryos and wild-type littermates. Analysis showed the expected increased expression of the Hsa21-orthologous genes on Mmu16 that are present in 3 copies. Gene set enrichment analysis identified pathways that are altered in Dp3Tyb and Ts1Rhr hearts.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
20 Samples

Download data: TXT

Series

Accession:: GSE196444

ID:: 200196444

PubMed Full text in PMC Similar studies

Select item 20019644317.

Transcriptomic analysis of human foetal hearts with or without Down Syndrome

(Submitter supplied) We performed bulk RNAseq on whole hearts from foetuses with Down syndrome and age-matched, sex-matched euploid controls. Analysis showed the expected increased expression of the genes on Hsa21 that are present in 3 copies. Gene set enrichment analysis identified pathways that are altered in DS hearts.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
10 Samples

Download data: TXT

Series

Accession:: GSE196443

ID:: 200196443

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014947018.

Multi-influential interactions controls behaviour and cognition through a limited number of pathways in Down syndrome mouse models

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Third-party reanalysis

Platform:: GPL6246
70 Samples

Download data: CEL

Series

Accession:: GSE149470

ID:: 200149470

PubMed Full text in PMC Similar studies

Select item 20014946919.

Multi-influential interactions controls behaviour and cognition through a limited number of pathways in Down syndrome mouse models (RNA-Seq reanalysis II)

(Submitter supplied) Down syndrome (DS) is the most common genetic form of intellectual disability with additional clinical features, caused by the presence of an additional copy of human chromosome 21 (Hsa21). A few number of patients with DS features, carry partial duplication of Hsa21 and their study provided novel insights into genotype–phenotype correlations. Despite the progress of genome analysis, the rareness of patients with partial duplication, and the human genetic heterogeneity, makes difficult to achieve a more detailed phenotypic map at present. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Third-party reanalysis

Download data: TXT, XLS

Series

Accession:: GSE149469

ID:: 200149469

PubMed Full text in PMC Similar studies

Select item 20014946720.

Multi-influential interactions controls behaviour and cognition through a limited number of pathways in Down syndrome mouse models (RNA-Seq reanalysis I)

(Submitter supplied) Down syndrome (DS) is the most common genetic form of intellectual disability with additional clinical features, caused by the presence of an additional copy of human chromosome 21 (Hsa21). A few number of patients with DS features, carry partial duplication of Hsa21 and their study provided novel insights into genotype–phenotype correlations. Despite the progress of genome analysis, the rareness of patients with partial duplication, and the human genetic heterogeneity, makes difficult to achieve a more detailed phenotypic map at present. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Third-party reanalysis

Download data: TXT, XLSX

Series

Accession:: GSE149467

ID:: 200149467

PubMed Full text in PMC Similar studies

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