GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Macaca mulatta; Chlorocebus aethiops

Type:

Expression profiling by high throughput sequencing

4 related Platforms

124 Samples

Download data

(Submitter supplied) We devised a systems biology approach to investigate the early host response to high-dose rectal SIV transmission, by transcriptomic comparative analysis of a natural reservoir host SIV model species, African green monkeys (AGMs – Chlorocebus sabaeus, N=28) and a pathogenic model, rhesus macaques (RMs - Macaca mulatta, N=24).on rectal tissues for both AGMs and RMs.

Organism:

Chlorocebus aethiops; Macaca mulatta

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21120 GPL22096

45 Samples

Download data: TXT

(Submitter supplied) We devised a systems biology approach to investigate the early host response to high-dose rectal SIV transmission, by transcriptomic comparative analysis of a natural reservoir host SIV model species, African green monkeys (AGMs – Chlorocebus sabaeus, N=28) and a pathogenic model, rhesus macaques (RMs - Macaca mulatta, N=24).on rectal tissues for both AGMs and RMs.

Organism:

Chlorocebus aethiops; Macaca mulatta

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24584 GPL14954

79 Samples

Download data: TXT

(Submitter supplied) Recent studies of nonhuman primates (NHPs) have suggested that during the acute phase of infection, antiviral mucosal immunity is restricting viral replication in the primary infection compartment. These studies imply that HIV achieves systemic infection as a consequence of a failure in host antiviral immunity. Here, we used high-dose intrarectal inoculation of rhesus macaques with SIVmac251 to examine how the mucosal immune system is overcome by SIV during acute infection. more...

Organism:

Macaca mulatta

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13766

23 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Chlorocebus pygerythrus; Erythrocebus patas; Macaca mulatta

Type:

Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

4 related Platforms

60 Samples

Download data: COV, TXT

(Submitter supplied) African green monkeys (AGMs) are natural hosts of Simian immunodeficiency virus (SIV) that post-thymically down-regulate CD4 to maintain a large population of CD4-CD8aa+ virus-resistant cells with T-helper functionality. AGMs can become aviremic and seemingly cured of SIV by down-regulating CD4 in all CD4+ T cells in vivo. To understand the mechanisms of this process we performed genome-wide transcriptional analysis on T cells induced to down-regulate CD4 in vitro from AGMs and closely-related Patas monkeys, and T cells that maintain CD4 expression from rhesus macaques. more...

Organism:

Erythrocebus patas; Macaca mulatta; Chlorocebus pygerythrus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL28631 GPL28632 GPL19129

48 Samples

Download data: TXT

(Submitter supplied) African green monkeys (AGMs) are natural hosts of Simian immunodeficiency virus (SIV) that post-thymically down-regulate CD4 to maintain a large population of CD4-CD8aa+ virus-resistant cells with T-helper functionality. AGMs can become aviremic and seemingly cured of SIV by down-regulating CD4 in all CD4+ T cells in vivo. To understand the mechanisms of this process we performed genome-wide transcriptional analysis on T cells induced to down-regulate CD4 in vitro from AGMs and closely-related Patas monkeys, and T cells that maintain CD4 expression from rhesus macaques. more...

Organism:

Chlorocebus pygerythrus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL28617

12 Samples

Download data: COV

(Submitter supplied) Pathogenic HIV/SIV infection of humans and rhesus macaques (RMs) induces persistently high production of type-I interferon (IFN-I) which is thought to contribute to disease progression. To elucidate the specific role of IFN in SIV pathogenesis, 12 RMs were treated prior to i.v. SIVmac239 infection with a high or a low dose of an antibody (AGS-009) that neutralizes most IFN subtypes, and compared with six mock-infused, SIV-infected controls. more...

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

107 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array; Expression profiling by RT-PCR

Platforms:

GPL17837 GPL16027

39 Samples

Download data: TXT

(Submitter supplied) The study describes miRNA expression in colon tissue following delta 9 tetrahydrocannabinol (Δ9-THC) administration to chronically SIV-infected rhesus macaques. To identify the underlying molecular mechanisms underlying its anti-inflammatory effects, we simultaneously profiled miRNA and mRNA expression in colon of chronically simian immunodeficiency virus (SIV)-infected rhesus macaques (RMs) administered either vehicle (VEH/SIV; n=9) or Δ9- tetrahydrocannabinol (THC; THC/SIV; n=8). more...

Organism:

Homo sapiens; Macaca mulatta

Type:

Expression profiling by RT-PCR

Platform:

GPL17837

23 Samples

Download data: XLSX

(Submitter supplied) We profiled and characterized mRNA expression in colon of 12 chronically SIV-infected rhesus macaques (RMs) receiving vehicle (n=7) or delta-9-tetrahydrocannabinol (THC) and 4 uninfected control macaques. Further analysis identified significant downregulation of genes associated with ion transport, epithelial barrier integrity/function, protection against oxidative injury, double stranded DNA damage repair and autophagy. more...

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL16027

16 Samples

Download data: TXT

(Submitter supplied) Objective: To evaluate the effect of short-term type I IFN treatment on the latent viral reservoir in SIV-infected rhesus macaques on ART; Methods: We infected twelve RMs intrarectally with 10,000 TCID of SIVmac239. After 6 weeks of infection, all RMs started a three-class, four-drug ART regimen. Once viral loads were consistently undetectable, six animals were administered 1 dose of pegylated IFN-α2a per week for 4 weeks with each weekly intramuscular application being 6 µg/kg.

Organism:

Macaca mulatta

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23804

35 Samples

Download data: TXT

(Submitter supplied) This study describes differential miRNA expression in small intestinal lamina propria leukocyte samples longitudinally during the course of SIV infection of rhesus macaques. Notably, the T-cell activation associated miR-15b, miR-142-3p, miR-142-5p and miR-150 expression was significantly downregulated at 90 and 180DPI. Further, reporter and overexpression assays validated IRAK1 as a direct miR-150 target. more...

Organism:

Homo sapiens; Macaca mulatta

Type:

Expression profiling by RT-PCR

Platform:

GPL17797

25 Samples

Download data: TXT

(Submitter supplied) The mucosa that lines the respiratory and gastrointestinal (GI) tracts is an important portal of entry for pathogens and provides the frontline of immune defense against HIV infection. Using the simian immunodeficiency virus (SIV) rhesus macaque model, we have performed a comparative analysis of host gene expression in the lung and GI mucosa in response to SIV infection and antiretroviral therapy. Microarrays were used to characterize changes in gene expression in the colonic, jejunal, and pulmonary (lung) mucosa that occur during chronic SIV infection in the presence or absence of antiretroviral therapy.

Organism:

Macaca mulatta

Type:

Expression profiling by array

Dataset:

GDS4993

Platform:

GPL3535

32 Samples

Download data: CEL

Analysis of colon, jejunum and lung from therapy-naïve, SIV-infected males. Gut and lung mucosa are important entry portals for pathogens and provide innate immune defense against infection. Results provide insight into molecular mechanisms underlying mucosal immune response during SIV infection.

Organism:

Macaca mulatta

Type:

Expression profiling by array, count, 2 infection, 3 tissue sets

Platform:

GPL3535

Series:

GSE51615

23 Samples

Download data: CEL