Similar studies for GEO DataSets (Select 200116062) - GEO DataSets

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Items: 17

Select item 2001160621.

Core Binding Factor β Is Required For Group-2 Innate Lymphoid Cell Activation

(Submitter supplied) Group-2 innate lymphoid cells (ILC2) are tissue-resident, long-lived innate effector cells implicated in allergy and asthma. Upon activation, mature ILC2 rapidly secret large amounts of type-2 cytokines and other effector molecules. The molecular pathways that drive ILC2 activation are not well understood. Here we report that the transcriptional controller Core-binding factor β (CBFβ) is required for ILC2 activation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17791
6 Samples

Download data: CEL

Series

Accession:: GSE116062

ID:: 200116062

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001118712.

Runx/Cbfβ complexes protect ILC2s from exhaustion during allergic airway inflammation

(Submitter supplied) Group 2 innate lymphoid cells (ILC2s) have tissue-resident competence and contribute to the pathogenesis of allergic diseases. Therefore, there should be mechanisms to maintain the capacity of ILC2s to produce TH2 cytokines under chronic inflammatory conditions. Here, we report that Runx proteins are essential to prevent exaggerated activation of ILC2, in part by antagonizing GATA-3 function at steady state. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18480 GPL17021
30 Samples

Download data: TXT, WIG

Series

Accession:: GSE111871

ID:: 200111871

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001293093.

Expression data from WT and KO of Myc in innate lymphoid cell 2 (ILC2) in mice

(Submitter supplied) Group-2 innate lymphoid cells (ILC2) serve crucial function in allergy and asthma. Activated ILC2 rapidly proliferate and secret large amounts of type-2 cytokines, such as IL-5 and IL-13. Mechanisms underlying still remain ambiguous. Here we report that Myc is required for ILC2 proliferation and activation in allergic airway inflammation. Inhibition of Myc impair the ILC2 proliferation in vivo and prevented ILC2-mediated airway hyperresponsiveness in vivo. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17791
6 Samples

Download data: CEL

Series

Accession:: GSE129309

ID:: 200129309

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000732724.

RNA-Seq analysis of mouse group 2 innate lymphoid cells (ILC2s) cultured with IL-33, IFN-g, and IL-27

(Submitter supplied) Purpose: We found that IFN-g and IL-27 had suppressive effects on ILC2s cultured with IL-33. The goal of this study is to clarify the expressions of RNA induced by IFN-g and IL-27 in ILC2s. Methods: ILC2s were isolated from fat-asociated lymphid clusters (FALC) of wild-type mice. They were cultured with IL-33 (10ng/ml), IL-33 + IFN-g (10ng/ml), or IL-33 + IL-27 (10ng/ml) for 48hrs. RNA was isolated by Allprep DNA/RNA Micro Kit (QIAGEN), and cDNA libraries were prepared by TruSeq RNA Sample Preparation kits v2 (Illumina) according to the manufacturer’s low sample protocol. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18480
9 Samples

Download data: TXT

Series

Accession:: GSE73272

ID:: 200073272

PubMed Similar studies SRA Run Selector

Select item 2001287355.

BET bromodomain inhibitor iBET151 impedes human ILC2 activation and prevents experimental allergic lung inflammation

(Submitter supplied) Group 2 innate lymphoid cells (ILC2) increase in frequency in eczema and allergic asthma patients, and thus represent a new therapeutic target cell for type-2 immune-mediated disease. The bromodomain and extra-terminal (BET) protein family of epigenetic regulators are known to support the expression of cell cycle and pro-inflammatory genes during type-1 inflammation, but have not been evaluated in type-2 immune responses. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
14 Samples

Download data: TXT

Series

Accession:: GSE128735

ID:: 200128735

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000988436.

Epigenome analysis reveals novel aspects of ILC2 activation and supports a pathogenic role in asthma

(Submitter supplied) Recent studies have shown that group 2 innate lymphoid cells (ILC2s) can drive eosinophilic airway inflammation in mouse models of asthma. Moreover, elevated ILC2 counts and/or activity have been reported in asthmatics, together suggesting that ILC2s play an important role in asthma pathophysiology. However, many aspects of ILC2 biology are not fully understood, including the mechanisms underlying ILC2 activation, the tissue-specific functions of ILC2s during inflammation (e.g. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL19057 GPL18573
15 Samples

Download data: BED, TXT

Series

Accession:: GSE98843

ID:: 200098843

PubMed Similar studies SRA Run Selector

Select item 2000906417.

Epigenome analyses implicate ILC2s as key mediators of allergic airway inflammation

(Submitter supplied) Group 2 innate lymphoid (ILC2) cells are major producers of the cytokines that drive allergic asthma and elevated levels of ILC2s have been detected in the blood and sputum of asthma patients. Asthma susceptibility has strong (epi)genetic components, but the underlying mechanisms and whether they are linked to ILC2 biology remain unclear. To reveal the molecular basis of ILC2 function in allergic airway inflammation (AAI) and assess its relevance for understanding how genetic variation affects asthma susceptibility. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
10 Samples

Download data: TXT

Series

Accession:: GSE90641

ID:: 200090641

PubMed Similar studies SRA Run Selector

Select item 2000973548.

RNA-Seq of ILC2p WT

(Submitter supplied) We have generated RNA-seq of ILC2 progenitors form WT bone marrow mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: TXT

Series

Accession:: GSE97354

ID:: 200097354

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000215619.

Gene expression analysis of CBFbeta knockdown PPC1 cells

(Submitter supplied) Whole genome array expression analysis was performed to identify changes in gene expression associated with the downregulation of the Core Binding Factor subunit CBFbeta.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
6 Samples

Download data: TXT

Series

Accession:: GSE21561

ID:: 200021561

Select item 20006743710.

Transcription factor Bcl11b controls identity and function of mature innate lymphoid cells type II

(Submitter supplied) Type-2 innate lymphoid cells (ILC2s) promote anti-helminth responses and contribute to allergies. Though Bcl11b has been previously considered a T-lineage identity transcription factor (TF) that restrains the innate-cell genetic programs, we report here that Bcl11b is highly expressed in mature ILC2s and acts upstream of the key ILC2 TFs Gfi1, Gata-3, and of IL-33 receptor IL1rl1 (T1ST2). Additionally, Bcl11b-/- ILC2s de-repressed Rorγt, Ahr and IL-23 receptor, normally expressed in type-3 ILCs (ILC3s). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: TXT

Series

Accession:: GSE67437

ID:: 200067437

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007974211.

Expression data of ILC2 cells from Ets1-deleted and littermate control mice

(Submitter supplied) The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE79742

ID:: 200079742

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009693412.

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation

(Submitter supplied) MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Group 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation. We established the physiological requirements for miRNAs in ILC2 homeostasis and immune function, and compared the global miRNA repertoire of resting and activated ILC2s and T helper type 2 (TH2) cells. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17021
23 Samples

Download data: CSV, XLSX

Series

Accession:: GSE96934

ID:: 200096934

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013420613.

Runx/CBFβ transcription factor complexes regulate Ccl5 expression through two novel enhancers to enhance tumor immunity [dataset 3]

(Submitter supplied) CCL5 (also known as RANTES) was originally known to be important to recruit memory T cells to infected sites, but it received much attention as an inhibitor to HIV’s entry into T lymphocytes of AIDS patients. Recently, it has been reported to be necessary to sustain Trm (Tissue-resident memory) T cells at local tissues as well as to play roles in manipulating tumor microenvironment by both host immunity and cancer cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TXT

Series

Accession:: GSE134206

ID:: 200134206

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013060014.

Runx/CBFβ transcription factor complexes regulate Ccl5 expression through two novel enhancers to enhance tumor immunity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL13112
14 Samples

Download data: BED, BW, TXT

Series

Accession:: GSE130600

ID:: 200130600

PubMed Full text in PMC Similar studies

Select item 20013059915.

Runx/CBFβ transcription factor complexes regulate Ccl5 expression through two novel enhancers to enhance tumor immunity [dataset 2]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: BW

Series

Accession:: GSE130599

ID:: 200130599

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013023516.

Runx/CBFβ transcription factor complexes regulate Ccl5 expression through two novel enhancers to enhance tumor immunity [dataset 1]

(Submitter supplied) CCL5 (also known as RANTES) was originally known to be important to recruit memory T cells to infected sites, but it received much attention as an inhibitor to HIV’s entry into T lymphocytes of AIDS patients. Recently, it has been reported to be necessary to sustain Trm (Tissue-resident memory) T cells at local tissues as well as to play roles in manuplating tumor microenvironment by both host immunity and cancer cells. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: BED

Series

Accession:: GSE130235

ID:: 200130235

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009063517.

Genome-wide maps of SATB1 bound regions in thymocytes and peripheral CD4+ T lymphocytes.

(Submitter supplied) T-cell receptor (TCR) signaling by MHC class-I and -II induces thymocytes to acquire cytotoxic and helper fates via induction of Runx3 or and ThPOK transcription factors, respectively. The mechanisms by The mechanisms by which TCR signaling is translated into transcriptional programs for each cell fate remain elusive. It remains elusivewhich how TCR signaling is translated into transcriptional programs for each cell fate remain elusive. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18480
8 Samples

Download data: WIG

Series

Accession:: GSE90635

ID:: 200090635

PubMed Full text in PMC Similar studies SRA Run Selector

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