Similar studies for GEO DataSets (Select 200116555) - GEO DataSets

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Items: 20

Select item 2001165551.

(Submitter supplied) We performed large-scale single-cell RNA-seq on human iPSCs subjected to endothelial cell differentiation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
2 Samples

Download data: RDA, TXT

Series

Accession:: GSE116555

ID:: 200116555

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001312932.

Vascular smooth muscle cell derived from iPS cell of Moyamoya disease - Comparative characterization with endothelial cell transcriptome

(Submitter supplied) Transcriptome analysis of vascular smooth muscle cells differentiated from iPS-derived neural crest stem cells in Moyamoya disease Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by steno-occlusive changes in the cerebral arteries at the base of the brain with unknown etiology, although histopathological features have demonstrated as fibrocellular thickening of the intima and medial thinning on the steno-occlusive arteries. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE131293

ID:: 200131293

Select item 2002407703.

Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

(Submitter supplied) Background:Port wine birthmark (PWB) is a congenital vascular malformation resulting from developmentally defective endothelial cells (ECs). Developing clinically relevant disease models for PWB studies is currently an unmet need. Objective: Our study aims to generate PWB-derived induced pluripotent stem cells (iPSCs) and iPSC-derived ECs that preserve disease-related phenotypes. Methods: PWB iPSCs were generated by reprogramming lesional dermal fibroblasts and differentiated into ECs. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
23 Samples

Download data: XLS, XLSX

Series

Accession:: GSE240770

ID:: 200240770

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Select item 2000942674.

Molecular and Functional Resemblance of Terminally Differentiated Cells Derived from Isogenic Human iPSCs and Somatic Cell Nuclear Transfer Derived ESCs

(Submitter supplied) Here we performed genome-wide RNA-seq and Reduced Representation Bisulfite Sequencing (RRBS-seq) in isogenic human induced pluripotent stem cells (iPSCs) and somatic cell nuclear transfer-derived embryonic stem cells (nt-ESCs), genetically matched in vitro fertilization-derived ESCs (IVF-ESCs), and their respective differentiated cells (cardiomyocytes and endothelial cells). We generated the transcriptome and DNA methylome map in human pluripotent stem cells and their differentiated cells with single-nucleotide resolution. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL16791 GPL17301
54 Samples

Download data: TXT

Series

Accession:: GSE94267

ID:: 200094267

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Select item 2001317365.

Transcriptional dynamics of pluripotent stem cell derived endothelial cell differentiation revealed by single cell RNA-Seq.

(Submitter supplied) Aims: Pluripotent stem cell-derived endothelial cell products possess therapeutic potential in ischemic vascular disease. However, the factors that drive endothelial differentiation from pluripotency and cellular specification are largely unknown. The aims of this study were to use single cell RNA sequencing (scRNA-seq) to map the transcriptional landscape and cellular dynamics of directed differentiation of human embryonic stem cell-derived endothelial cells (hESC-EC), and to compare these cells to mature endothelial cells from diverse vascular beds.Methods and Results: A highly efficient directed 8-day differentiation protocol was used to generate a hESC-derived endothelial cell product (hESC-ECP), in which 66% of cells coexpressed CD31 and CD144. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL20301
16 Samples

Download data: H5

Series

Accession:: GSE131736

ID:: 200131736

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Select item 2001423226.

Genome wide RNA-sequencing of human pluripotent stem-cell derived endothelial cells treated with TGF-beta receptor inhbitors with or without VEGFA stimulation

(Submitter supplied) Transcriptional response to TGF-beta receptor inhibtion with or without VEGFA stimulation

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
42 Samples

Download data: XLSX

Series

Accession:: GSE142322

ID:: 200142322

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Select item 2001423217.

Genome wide RNA-sequencing of sorted human pluripotent stem-cell derived endothelial cells with CLDN5-GFP reporter (GFP+ and GFP-)

(Submitter supplied) CLDN5-GFP reporter has been engineered in hPSCs. These cells have been differentiated to Ecs. Differentaited Ecs were sorted into GFP+ and GFP- corresponding to CLDN5+ and CLDN5- to study gene expression of high-barrier resistance.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
24 Samples

Download data: XLSX

Series

Accession:: GSE142321

ID:: 200142321

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Select item 2002023988.

Combined Lineage Tracing and scRNA-seq Reveals Unexpected First Heart Field Predominance of Human iPSC Differentiation

(Submitter supplied) During mammalian development, the left and right ventricles arise from early populations of cardiac progenitors known as the first and second heart fields, respectively. While these populations have been extensively studied in non-human model systems, their identification and study in vivo human tissues have been limited due to the ethical and technical limitations of accessing gastrulation stage human embryos. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
3 Samples

Download data: H5, XLSX

Series

Accession:: GSE202398

ID:: 200202398

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Select item 2000543879.

Expression data from induced pluripotent stem cell-derived endothelial cells from healthy and diet-induced obesity mice

(Submitter supplied) Little is known about the function of induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) generated from diabetics, as this could potentially limit subsequent therapeutic use in this patient population. Here, we demonstrate that iPSC-ECs derived from diet-induced obesity (DIO) mice exhibit evidence of endothelial dysfunction. We also observed that mice receiving intramuscular (IM) injections of DIO iPSC-ECs had significantly decreased reperfusion following hindlimb ischemia compared to mice administered with iPSC-ECs from control mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE54387

ID:: 200054387

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Select item 20019591110.

Mapping the developing human cardiac endothelium at single cell resolution identifies MECOM as a regulator of arteriovenous identity.

(Submitter supplied) Aims: Coronary vasculature formation is a critical event during cardiac development, essential for heart function throughout perinatal and adult life. However, current understanding of coronary vascular development has largely been derived from transgenic mouse models. The aim of this study was to characterise the transcriptome of the human fetal cardiac endothelium using single-cell RNA sequencing (scRNA-seq) to provide critical new insights into the cellular heterogeneity and transcriptional dynamics that underpin endothelial specification within the vasculature of the developing heart. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
10 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE195911

ID:: 200195911

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Select item 20006979011.

Single cell transcriptomics analysis of induced pluripotent stem cell-derived cortical neurons reveals frequent dual layer identity

(Submitter supplied) Induced pluripotent stem cell (iPSC)-derived cortical neurons present a powerful new model of neurological disease. Previous work has established that differentiation protocols produce cortical neurons but little has been done to characterise these at cellular resolution. In particular, it is unclear to what extent in vitro two-dimensional, relatively disordered culture conditions recapitulate the development of in vivo cortical layer identity. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
16 Samples

Download data: TXT

Series

Accession:: GSE69790

ID:: 200069790

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006930212.

SNP data from AH017 human fibroblasts and induced Pluripotent Stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; SNP genotyping by SNP array

Platforms:: GPL13829 GPL10558
5 Samples

Download data

Series

Accession:: GSE69302

ID:: 200069302

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Select item 20006928813.

Transcriptome data from induced Pluripotent Stem cells

(Submitter supplied) We have generated human induced Pluripotent Stem cells (hiPSc) using Sendai virus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotency of the hiPSc lines is provided by Pluritest assessment of transcriptome datasets, prior to differentiation and downstream assays. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
2 Samples

Download data: TXT

Series

Accession:: GSE69288

ID:: 200069288

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Select item 20006928714.

SNP data from human fibroblasts and induced Pluripotent Stem cells.

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platform:: GPL13829
3 Samples

Download data: TXT

Series

Accession:: GSE69287

ID:: 200069287

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Select item 20018680315.

iPSC-EC RNA-seq

(Submitter supplied) The goal of this project was to analyze the genetic profile of endothelial cells derived from iPSCs of controls and TGA patients. Two control and two TGA iPSCs were analyzed

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: TXT

Series

Accession:: GSE186803

ID:: 200186803

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Select item 20003763116.

Human Pluripotent Cell Derived Endothelial Cell Characterization

(Submitter supplied) Human ES or iPS Cells were differentiated into endothelial cells (ECs) defined by expression of CD31 (PECAM1) and CD144 (VE-Cadherin) on the cell surface. All ES or iPS derived ECs were greater than 90% double positive for these two markers. These in vitro derived ECs were compared to each other and to ECs from primary cell sources; arterial (aortic Ecs), venous (saphenous vein) and lymphatic.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
12 Samples

Download data: CEL

Series

Accession:: GSE37631

ID:: 200037631

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Select item 20024745017.

MERFISH reveals embryonic endothelial heterogeneity

(Submitter supplied) The heterogeneity of embryonic endothelial cells (ECs) especially the distinction of arteriovenous ECs remains incompletely characterized. We established a mouse single-EC transcriptomic landscape at mid-to-late gestation stage and identified 19 subclusters, including Etv2+Bnip3+ early ECs and 2 specialized ECs. Most of these subtypes were grouped by their vascular-bed types, while ECs from brain, heart and liver were grouped by their tissue origins. more...

Organism:: Mus musculus; synthetic construct

Type:: Other

Platform:: GPL31217
3 Samples

Download data: CSV

Series

Accession:: GSE247450

ID:: 200247450

PubMed Similar studies

Select item 20024744918.

Bulk RNA-seq reveals effects of tamoxifen on endothelial gene expression

(Submitter supplied) Transgenic line combination with tamoxifen induction is widely used for biological study. Considering the possibility that tamoxifen induction may alter gene expression, we performed this study to elucidate the potential effect of tamoxifen gavage on the gene expression profile of endothelial cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: TXT

Series

Accession:: GSE247449

ID:: 200247449

PubMed Similar studies

Select item 20021697019.

Single-cell transcriptome Atlas reveals embryonic endothelial heterogeneity

(Submitter supplied) Mature endothelial cells (ECs) are heterogeneous, with subtypes defined by tissue origin and by position within the vascular bed. Here, we performed scRNA-seq with mouse embryonic ECs and identified 19 subclusters, including Etv2+Bnip3+ early EC progenitors. Most of these subtypes were grouped by their vascular-bed types, while ECs from brain, heart and liver were grouped by their tissue origins. Compared to arterial ECs (aECs), embryonic venous (vECs) and capillary ECs (cECs) shared less markers with their adult counterparts. more...