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Metabolic Alterations in JAK2 Mutant Hematopoietic Cells Represent Therapeutic Vulnerabilities for Myeloproliferative Neoplasms
PubMed Full text in PMC Similar studies SRA Run Selector
Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and JAK2-V617F expressing hematopoietic stem and progenitor subsets
Effects of the treatment with pegIFNa, Azacytidine or pegIFNa+Azacytidine in LT-HSCs from JAK2-V617F MPN mice or JAK2-V617F;Dnmt3a-KO MPN mice.
PubMed Full text in PMC Similar studies
Gene expression profile at single cell level of phenotypic LT-HSCs from single-mutant JAK2 V617F and double mutant JAK2 V617F;Dnmt3a-/- mice
Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis
Next Generation Sequencing of long-term hematopoietic cells (LT-HSCs) with or without mutations in JAK2 and Ezh2
Next Generation Sequencing of megakaryocyte-erythrocyte progenitor cells (MEPs) with or without mutations in JAK2 and Ezh2
Oncostatin M effects in IMR90 cells
PubMed Similar studies Analyze with GEO2R
IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells
Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm
Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms
Sympathetic neuropathy of the bone marrow haematopoietic stem cell niche is essential for myeloproliferative neoplasms
Neuropathy of the haematopoietic stem cell niche is essential for myeloproliferative neoplasms [RNA-seq]
PubMed Similar studies SRA Run Selector
Gene expression analyses of hematopoietic stem cell (HSC) subsets in wildtype or CD41-KO mice
Hematopoietic Stem Cell Heterogeneity in JAK2 V617F+ Essential Thrombocythemia
PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector
AG221 and Ruxolitinib Treatment Effects on LSKs in IDH2-R140Q JAK2-V617F Transplant Recipients
Gene expression data from lineage negative c-kit positive sca-1 positive hematopoietic stem cells (LSK, Lin-Sca-1+c-kit+) isolated from Jak2VF/+ vector and Jak2VF/+ Hmga2 mice
Thrombopoietin metabolically primes hematopoietic stem cells to megakaryocyte lineage differentiation
The HDAC inhibitor Givinostat modulates key hematopoietic genes in JAK2V617F cells, affecting proliferation, differentiation and apoptosis
HMGA1 Chromatin Regulators Drive MPN Progression [scRNA-Seq]
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