GEO DataSets

(Submitter supplied) The skeletal muscle system plays an important role in the independence of older adults. In this study we examine differences in the skeletal muscle transcriptome between healthy young and older subjects and (pre‐)frail older adults. Additionally, we examine the effect of resistance‐type exercise training on the muscle transcriptome in healthy older subjects and (pre‐)frail older adults. Baseline transcriptome profiles were measured in muscle biopsies collected from 53 young, 73 healthy older subjects, and 61 frail older subjects. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20880

259 Samples

Download data: CEL

(Submitter supplied) Human aging is associated with skeletal muscle atrophy and functional impairment (sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction is a major contributor to sarcopenia. We evaluated whether healthy aging was associated with a transcriptional profile reflecting mitochondrial impairment and whether resistance exercise could reverse this signature to that approximating a younger physiological age. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2700

65 Samples

Download data: CSV

(Submitter supplied) Global microarray (HG U133 Plus 2.0) was used to investigate the effects of resistance exercise and resistance training on the skeletal muscle transcriptome profile of 28 young and old adults. Vastus lateralis muscle biopsies were obtained pre and 4hrs post resistance exercise in the beginning (untrained state) and at the end (trained state) of a 12 wk progressive resistance training program.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5218

Platform:

GPL570

110 Samples

Download data: CEL, CHP

(Submitter supplied) Global microarray (HG U133 Plus 2.0) was used for the first time to investigate the effects of resistance exercise on the transcriptome in slow-twitch myosin heavy chain (MHC) I and fast-twitch MHC IIa muscle fibers of young and old women. Vastus lateralis muscle biopsies were obtained pre and 4hrs post resistance exercise in the beginning (untrained state) and at the end (trained state) of a 12 wk progressive resistance training program.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5217

Platform:

GPL570

70 Samples

Download data: CEL, CHP

(Submitter supplied) Global microarray (HG U133 Plus 2.0) was used to investigate the basal level skeletal muscle transcriptome profile of young and old adults. One vastus lateralis muscle biopsy was obtained in the basal state from 36 different subjects.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5216

Platform:

GPL570

36 Samples

Download data: CEL, CHP

Analysis of vastus lateralis muscle biopsy samples from young (about 24 years old) and old (about 84 years old) adults before and after 12 weeks of progressive resistance training. Results provide insight into the molecular adaptation of the young and old skeletal muscle to resistance training.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age, 2 gender, 4 time sets

Platform:

GPL570

Series:

GSE28422

110 Samples

Download data: CEL, CHP

Analysis of slow-twitch MHC I and fast-twitch MHC IIa muscle fibers from young and old women before and after 12 weeks of progressive resistance training. Fibers obtained from vastus lateralis. Results provide insight into the molecular adaptation of young and old MHC I and IIa fibers to exercise.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age, 14 individual, 4 time, 2 tissue sets

Platform:

GPL570

Series:

GSE28392

70 Samples

Download data: CEL, CHP

Analysis of vastus lateralis muscle biopsy samples from young (about 25 years old) and old (about 78 years old) adults. Subjects had not taken part in formal exercise. Results provide insight into the effect of age on basal gene expression in the skeletal muscle.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age, 2 gender sets

Platform:

GPL570

Series:

GSE25941

36 Samples

Download data: CEL, CHP

(Submitter supplied) The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. The purpose of the study was to detect the sex differences in the skeletal muscle transcriptome in both the resting state and following anabolic stimuli, resistance exericse.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

28 Samples

Download data: CEL, CHP

(Submitter supplied) Vitamin D deficiency is common among older adults and has been linked to muscle weakness. Vitamin D supplementation has been proposed as a strategy to improve muscle function in older adults. The aim of this study was to investigate the effect of calcifediol (25-hydroxycholecalciferol) on whole genome gene expression in skeletal muscle of vitamin D deficient frail older adults. A double-blind placebo controlled trial was conducted in vitamin D deficient frail older adults (aged above 65), characterized by blood 25-hydroxycholecalciferol concentrations between 20 and 50 nmol/L. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17692

44 Samples

Download data: CEL

(Submitter supplied) We used gene microarray analysis to compare the global expression profile of genes involved in adaptation to exercise training in skeletal muscle from chronically strength/resistance trained (ST), endurance trained (ET) and untrained control subjects (Con). Resting skeletal muscle samples (~100mg) were obtained from the vastus lateralis of 20 subjects (Con n=7, ET n=7, ST n=6; trained groups >8 years specific training). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6042

21 Samples

Download data: GPR

(Submitter supplied) 18 older (65-71 years) and 20 young (19-25 years) males were recruited based on similar, self-reported physical activity, which was verified using accelerometry measurements. Gene expression profiles of vastus lateralis biopsies obtained by RNA sequencing. A clear ageing signature was observed despite similar physcical activity.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23227

38 Samples

Download data: TXT

(Submitter supplied) The aim of this investigation was to evaluate the effect of training on the global transcriptional response of skeletal muscle to an acute bout of resistance exercise.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4894

Platform:

GPL570

14 Samples

Download data: CEL

Analysis of biceps brachii muscles from trained and untrained arms 4 hours after an acute bout of bilateral arm resistance exercise (RE). Subjects underwent a 12 week progressive unilateral arm RE training program. Results provide insight into the adaptive response of skeletal muscle to RE training.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 gender, 7 individual, 2 protocol sets

Platform:

GPL570

Series:

GSE28998

14 Samples

Download data: CEL

(Submitter supplied) While acute aerobic and resistance exercise stimulate a number of shared genes, each exercsie mode stimlutes a number of uniquely responsive genes, thus highlighting that different forms of exercise facilitate distinct molecular responses in skeletal muscle.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

29 Samples

Download data: TXT

(Submitter supplied) Evidence from clinical trials and observational studies suggests that both progressive resistance training (PRT) and metformin delay a variety of age-related morbidities. Previously, we completed a clinical trial testing the effects of 14 weeks of PRT + metformin (metPRT) compared to PRT with placebo (plaPRT) on muscle hypertrophy in older adults. We found that metformin blunted PRT-induced muscle hypertrophic response. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

136 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

50 Samples

Download data: CEL

(Submitter supplied) Background: Cold acclimation and exercise training were previously shown to increase peripheral insulin sensitivity in human volunteers with type 2 diabetes. Although cold is a potent activator of brown adipose tissue, the increase in peripheral insulin sensitivity by cold is largely mediated by events occurring in skeletal muscle and at least partly involves GLUT4 translocation, as is also observed for exercise training. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

14 Samples

Download data: CEL

(Submitter supplied) Background: Cold acclimation and exercise training were previously shown to increase peripheral insulin sensitivity in human volunteers with type 2 diabetes. Although cold is a potent activator of brown adipose tissue, the increase in peripheral insulin sensitivity by cold is largely mediated by events occurring in skeletal muscle and at least partly involves GLUT4 translocation, as is also observed for exercise training. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

36 Samples

Download data: CEL

(Submitter supplied) Background: Exercise has a positive effect on overall health. This study was performed to get an overview of the effects of mixed exercise training on skeletal muscl

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

36 Samples

Download data: CEL