U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 13

1.

Global transcriptomic investigation of the human macrophage response towards pathogenic/non-pathogenic mycobacteria

(Submitter supplied) We present an infection study with pathogenic and non-pathogenic mycobacterial strains that have vastly different characteristics. The early/late host response to infection with these detergent-free cultured strains will be analysed through Ampliseq and further validated through qPCR in an attempt to provide information on the subtleties which may ultimately contribute to the virulent phenotype. Proceeding to the next objective of the study is to knock-down (siRNA)/knock-up (saRNA) selected differentially expressed mRNA to study their role in the intracellular survival of M. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17303
84 Samples
Download data: TXT, XLS
2.

Nonpathogenic SIV and Pathogenic HIV Infections Associate with Disparate Innate Cytokine Signatures in Response to M. bovis BCG

(Submitter supplied) Infections with mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium bovis (M. bovis) BCG, are a leading cause of morbidity and mortality for HIV-infected persons. In contrast to HIV, SIV infection of sooty mangabeys is nonpathogenic, characterized by a lack of clinical disease including an absence of opportunistic infections. The goal of this study was to identify innate immune responses to M. more...
Organism:
Cercocebus atys; Homo sapiens; Macaca mulatta
Type:
Expression profiling by array
Platform:
GPL21947
44 Samples
Download data: RCC
Series
Accession:
GSE81926
ID:
200081926
3.

Mycobacterial infection induces a specific human innate immune response

(Submitter supplied) The innate immune system provides the first response to pathogen infection and orchestrates the activation of the adaptive immune system. Though a large component of the innate immune response is common to all infections, pathogen-specific innate immune responses have been documented as well. The innate immune response is thought to be especially critical for fighting infection with Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
156 Samples
Download data: TXT
4.

Differentially regulated genes induced in Mycobacterium by in vitro acid-nitrosative multi-stress

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mycolicibacterium smegmatis MC2 155; Mycobacterium tuberculosis H37Rv
Type:
Expression profiling by array
Platforms:
GPL14591 GPL14580
2 Samples
Download data: GPR
Series
Accession:
GSE34624
ID:
200034624
5.

Differentially regulated genes induced in Mycobacterium tuberculosis by in vitro acid-nitrosative multi-stress

(Submitter supplied) Transcriptional profile of Mycobacterium tuberculosis in in vitro acid-nitrosative multistress, comparing untreated control cells and bacteria under multi-stress.
Organism:
Mycobacterium tuberculosis H37Rv
Type:
Expression profiling by array
Platform:
GPL14591
1 Sample
Download data: GPR
Series
Accession:
GSE34623
ID:
200034623
6.

Differentially regulated genes induced in Mycobacterium smegmatis by in vitro acid-nitrosative multi-stress

(Submitter supplied) Transcriptional profile of Mycobacterium smegmatis in in vitro acid-nitrosative multistress, comparing untreated control cells and bacteria under multi-stress.
Organism:
Mycolicibacterium smegmatis MC2 155; Mycobacterium tuberculosis H37Rv
Type:
Expression profiling by array
Platforms:
GPL14591 GPL14580
2 Samples
Download data: GPR
Series
Accession:
GSE34622
ID:
200034622
7.

AmpliSeq Transcriptome Analysis of Human Alveolar and Monocyte-Derived Macrophages Over Time in Response to Mycobacterium tuberculosis infection

(Submitter supplied) Human alveolar macrophages (HAM) are primary bacterial niche and immune response cells during Mycobacterium tuberculosis (M.tb) infection, and human blood monocyte-derived macrophages (MDM) are a model for investigating M.tb-macrophage interactions. Here, we use a targeted RNA-Seq method to measure transcriptome-wide changes in RNA expression patterns of freshly obtained HAM (used within 6 h) and 6 day cultured MDM upon M.tb infection over time (2, 24 and 72 h), in both uninfected and infected cells from three donors each. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17303
36 Samples
Download data: TXT
Series
Accession:
GSE114371
ID:
200114371
8.

Transcriptome analysis in host defense during high multiplicity mycobacterial infection

(Submitter supplied) This experiment is to compare the transcription patterns of mouse macrophages (J774A.1) infected with BCG, H37Ra and M. smegmatis under high multiplicity of infection (MOI). Through the global transcriptome profiling study, we define a pathogen specific host gene expression pattern and indicate that SRC likely plays a central role in regulating multiple unique signaling pathways activated by MTB infection. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5634
Platform:
GPL1261
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE45675
ID:
200045675
9.
Full record GDS5634

High multiplicity mycobacterial infections of macrophages in vitro

Analysis of macrophage cell line J774A.1 infected with pathogenic mycobacteria BCG and H37Ra and non-pathogenic M. smegmatis under high multiplicity of infection (MOI = 50). Results provide insight into the molecular response of macrophage host cells to pathogenic and non-pathogenic mycobacteria.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 infection, 4 species sets
Platform:
GPL1261
Series:
GSE45675
4 Samples
Download data: CEL, CHP
10.

The lack of the TetR-like repressor gene BCG_2177c (Rv2160A) may help mycobacteria overcome intracellular redox stress and survive longer inside macrophages when surrounded by a lipid environment

(Submitter supplied) We analyzed the genes expressed, or the transcriptome, of bacilli Mycobacterium bovis BCG Pasteur (wtBCG) and a mutant strain obtained by transposition of the gene BCG_ BCG_2177c (mtBCG), cultured in the presence of a lipid mixture (fatty acids/cholesterol) as main carbon source. Using RNAseq we identified a group of genes that provides novel insight regarding the metabolic pathways and transcriptional regulation, and pathogenic features that were influenced by BCG_2177c gene, a TetR-like repressor, during the lipid metabolism in slow-growing mycobacteria that could be extrapolated to other members of the MTBC.
Organism:
Mycobacterium tuberculosis variant bovis BCG
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29423
8 Samples
Download data: TXT
Series
Accession:
GSE175579
ID:
200175579
11.

A Lysosomal In Vitro Exposure (LivE) Model to Identify Pathways Critical for Mycobacterium tuberculosis Intracellular Persistence

(Submitter supplied) Increasing experimental evidence supports that Mycobacterium tuberculosis (Mtb) has evolved strategies to survive within the lysosomes from activated macrophages, which may represent a reservoir for persistent mycobacteria. To further our knowledge in Mtb response to the lysosomal environment, we profiled the global transcriptional activity of Mtb in a lysosomal in vitro exposure (LivE) model. At inhibitory conditions of lysosomal SF (iLivE), which did not kill but arrested mycobacterial replication thereby mimicking persistence, Mtb expresses a unique transcriptome, where genes involved in general stress response, metabolic reprogramming, cell wall remodeling, respiration, oxidative stress and dormancy response were found to be significantly modulated. more...
Organism:
Mycobacterium tuberculosis CDC1551
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20114
15 Samples
Download data: TXT
Series
Accession:
GSE68337
ID:
200068337
12.

RNAseq Reveals Virulence-Specific Host Responses to M. tuberculosis infection

(Submitter supplied) We infect bone marrow derived macrophages (BMDMs) with either a Hyper or Hypovirulent Mycobacterium tuberculolsis strain and assess the host response to these bacteria through RNAseq
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15907
9 Samples
Download data: TXT
Series
Accession:
GSE78706
ID:
200078706
13.

Next Generation Sequencing Facilitates Quantitative Analysis of Zinc treated Wild-Type or CmtR-deleted strains of Mycobacterium bovis BCG Transcriptomes

(Submitter supplied) The goal of this study aims to quantitatively compare the gene expression difference in wild-type or cmtR-deleted strains of Mycobacterium bovis BCG with and without excess zinc treatment at the transcriptome level and find the underlying mechanism how could excess zinc inhibit mycobacterial growth and its relation with transcription factor CmtR.
Organism:
Mycobacterium tuberculosis variant bovis BCG
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30387
12 Samples
Download data: TXT
Series
Accession:
GSE179966
ID:
200179966
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=3|qty=9|blobid=MCID_672d27d55614fa63672a1f0c|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center