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Links from GEO DataSets

Items: 14

1.

Effect of Ramoplanin treatment on hESC-RPE transcriptome during POS phagocytosis

(Submitter supplied) we report the effect of Ramoplanin on the transcription profile of RPE cells in comparison to DMSO (Vehicle) or MFGE8+GAS6 treated cells in the presence and absence of POS
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
21 Samples
Download data: TXT
Series
Accession:
GSE132828
ID:
200132828

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

transcriptional profiling of H9 human embronic stem cells (hESC) and hESC derived retinal pigment epithelium (RPE)

(Submitter supplied) RPE was derived from hESC based on the protocol described in Zhu et al. PlosOne. 2013.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE127352
ID:
200127352

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

3.

Genetic profiling of developing human embryonic stem cell derived Retinal pigmented epithelium

(Submitter supplied) Age-related macular degeneration is a progressive disease resulting in impaired central vision. Degeneration of the retinal pigmented epithelial (RPE) monolayer is associated with the progression of the disease. To date no treatment is able to stop this progression, however new cell replacement studies using human embryonic stem cells (hESC) to generate RPE show a promising prospective. To improve cell replacement strategies a better understanding about the development of RPE cells is necessary. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
12 Samples
Download data: TXT
Series
Accession:
GSE85907
ID:
200085907

PubMed Full text in PMC Similar studies Analyze with GEO2R

4.

RNA-Seq of tissues from Rat eye and retina samples

(Submitter supplied) We report RNA-Seq experiments of eye and retinal tissues from Rattus Norvegicus
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL10669
4 Samples
Download data: TXT
Series
Accession:
GSE84932
ID:
200084932

PubMed Full text in PMC Similar studies SRA Run Selector

5.

RNA-Seq of retinal tissue from a Human Eye

(Submitter supplied) We report RNA-Seq experiments of retinal tissue from Homo Sapiens
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL10999
2 Samples
Download data: TXT
Series
Accession:
GSE84930
ID:
200084930

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

6.

RNA-Seq of eye tissues from C57BL/6J background mice at 1.5 h and 9.0 h after light onset

(Submitter supplied) We report RNA-Seq experiments of whole eye tissues from C57BL/6J background mice at 1.5 h and 9.0 h after light onset to better understand photoreceptor phagocytosis
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11002
6 Samples
Download data: TXT
Series
Accession:
GSE48974
ID:
200048974

PubMed Full text in PMC Similar studies SRA Run Selector

7.

RNA-Seq of eye tissues from A/J, BALB/c, and C57BL/6 background mice

(Submitter supplied) We report RNA-Seq experiments of whole eye tissues from A/J, BALB/c, and C57BL/6 background mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11002
9 Samples
Download data: TXT
Series
Accession:
GSE38359
ID:
200038359

PubMed Full text in PMC Similar studies SRA Run Selector

8.

RNA-Seq of mouse eye and retina tissues from wild type and Nrl transcription factor knockout mice

(Submitter supplied) The initial aim of this work was to understand the pathophysiology of Enhanced S-cone Syndrome (ESCS) that leads to retinal degeneration. Although ESCS was identified in humans decades ago and since then the causative genes have been elucidated, our understanding of the accompanying retinal degeneration is still poorly understood. Knockout of the Nrl transcription factor in mice produces a retina overpopulated with S-cone like photoreceptors along with absence of rod photoreceptors and recapitulates many of the phenotypic features seen in human ESCS patients. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11002
4 Samples
Download data: TXT
Series
Accession:
GSE29752
ID:
200029752

PubMed Full text in PMC Similar studies SRA Run Selector

9.

RNA-seq of mouse cultured retinal pigment epithelium (RPE) challenged with photoreceptor outer segments (POS).

(Submitter supplied) Primary culture of mouse RPE cells (C57BL/6J background) was challenged with POS for 90 min and subjected for RNA-seq.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11002
6 Samples
Download data: XLSX
Series
Accession:
GSE96626
ID:
200096626

PubMed Full text in PMC Similar studies SRA Run Selector

10.

Core Circadian Clock Genes Per1 and Per2 regulate the Rhythm in Photoreceptor Outer Segment Phagocytosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
56 Samples
Download data
Series
Accession:
GSE172440
ID:
200172440

PubMed Similar studies

11.

Core Circadian Clock Genes Per1 and Per2 regulate the Rhythm in Photoreceptor Outer Segment Phagocytosis [RPE]

(Submitter supplied) Retinal photoreceptors undergo daily renewal of their distal outer segments, a process indispensable for maintaining retinal health. Photoreceptor Outer Segment (POS) phagocytosis occurs as a daily peak, roughly about one hour after light onset. However, the underlying cellular and molecular mechanisms which initiate this process are still unknown. Here we show that, under constant darkness, mice deficient for core circadian clock genes (Per1 and Per2), lack a daily peak in POS phagocytosis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
24 Samples
Download data: TXT
Series
Accession:
GSE172438
ID:
200172438

PubMed Similar studies SRA Run Selector

12.

Core Circadian Clock Genes Per1 and Per2 regulate the Rhythm in Photoreceptor Outer Segment Phagocytosis [Photoreceptor]

(Submitter supplied) Retinal photoreceptors undergo daily renewal of their distal outer segments, a process indispensable for maintaining retinal health. Photoreceptor Outer Segment (POS) phagocytosis occurs as a daily peak, roughly about one hour after light onset. However, the underlying cellular and molecular mechanisms which initiate this process are still unknown. Here we show that, under constant darkness, mice deficient for core circadian clock genes (Per1 and Per2), lack a daily peak in POS phagocytosis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
32 Samples
Download data: TXT
Series
Accession:
GSE172437
ID:
200172437

PubMed Similar studies SRA Run Selector

13.

INFLAMMATION OF THE RETINAL PIGMENT EPITHELIUM DRIVES EARLY-ONSET PHOTORECEPTOR DEGENERATION IN MERTK-ASSOCIATED RETINITIS PIGMENTOSA

(Submitter supplied) Severe, early-onset photoreceptor (PR) degeneration associated with MERTK mutations is thought to result from failed phagocytosis by retinal pigment epithelium (RPE). Notwithstanding, the severity and onset of PR degeneration in mouse models of Mertk ablation is determined by the hypomorphic expression or the loss of the Mertk paralog Tyro3. Here we find that loss of Mertk and reduced expression/loss of Tyro3 led to RPE inflammation, even before eye-opening. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
18 Samples
Download data: XLSX
Series
Accession:
GSE214005
ID:
200214005

PubMed Full text in PMC Similar studies

14.

Tissue-specific modifier alleles determine Mertk loss-of-function traits

(Submitter supplied) Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a consequence of gene KO, mice display certain phenotypes. Based on insight into the molecular role of said gene in a biological process, it is inferred that the particular biological process causally underlies the trait. This approach has been crucial towards understanding the basis of pathological and/or advantageous traits associated with Mertk KO. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
30 Samples
Download data: TXT
Series
Accession:
GSE205070
ID:
200205070

PubMed Full text in PMC Similar studies

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