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Links from GEO DataSets

Items: 4

1.

The sulfur stress response caused by sodium hydrosulfide, allicin and diallyl polysulfanes in Bacillus subtilis as revealed by transcriptomics

(Submitter supplied) In this study, we compared the transcriptome signatures in response to sodium hydrosulfide (NaHS), allicin and diallyl tetrasulfane (DAS4) exposure in the Gram-positive bacterium Bacillus subtilis. This analysis revealed that NaHS, allicin and DAS4 caused a similar thiol-specific oxidative and electrophile stress response as well as protein and DNA damage.
Organism:
Bacillus subtilis subsp. subtilis str. 168; Bacillus subtilis
Type:
Expression profiling by array
Platform:
GPL21669
6 Samples
Download data: TXT
Series
Accession:
GSE132981
ID:
200132981
2.

S-bacillithiolation protects against hypochlorite stress in Bacillus subtilis as revealed by transcriptomics and redox proteomics

(Submitter supplied) Protein S-thiolation is a post-translational thiol-modification that controls redox-sensing transcription factors and protects active site cysteine residues against irreversible oxidation. In Bacillus subtilis the MarR-type repressor OhrR was shown to sense organic hydroperoxides via formation of mixed disulfides with the redox buffer bacillithiol (Cys-GlcN-Malate, BSH), termed as S-bacillithiolation. more...
Organism:
Bacillus subtilis subsp. subtilis str. 168
Type:
Expression profiling by array
Platform:
GPL10901
3 Samples
Download data: TXT
Series
Accession:
GSE27637
ID:
200027637
3.

Paralogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilis

(Submitter supplied) The redox-sensing MarR/DUF24-type repressor YodB controls expression of the azoreductase AzoR1 and the nitroreductase YodC that are involved in detoxification of quinones and diamide in Bacillus subtilis. In the present paper, we identified YodB and its paralog YvaP (CatR) as repressors of the yfiDE (catDE) operon encoding a catechol-2,3-dioxygenase that also contributes to quinone resistance. Inactivation of both paralogs, CatR and YodB, results in full derepression of catDE transcription. more...
Organism:
Bacillus subtilis
Type:
Expression profiling by array
Platform:
GPL3502
2 Samples
Download data: TXT
Series
Accession:
GSE22603
ID:
200022603
4.

The global expression profile of Bacillus subtilis to the toxic carbonyls methylglyoxal (MG) and formaldehyde (FA)

(Submitter supplied) Abstract of associated menuscript; Quinones and alpha,beta-unsaturated carbonyls are naturally occurring electrophiles that target cysteine residues via thiol-(S)-alkylation. We analyzed the global expression profile of Bacillus subtilis to the toxic carbonyls methylglyoxal (MG) and formaldehyde (FA). Both carbonyl compounds cause a stress response characteristic for thiol-reactive electrophiles as revealed by the induction of the Spx, CtsR, CymR, PerR, ArsR, CzrA, CsoR and SigmaD regulons. more...
Organism:
Bacillus subtilis
Type:
Expression profiling by array
Platform:
GPL3502
9 Samples
Download data: TXT
Series
Accession:
GSE13925
ID:
200013925
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