Similar studies for GEO DataSets (Select 200133396) - GEO DataSets

Select item 2001333961.

Effect of ZIKV on human ESCs derived trophoblast cells

(Submitter supplied) To characterise the human trophoblast cells derived from human ESCs and the effects of ZIKV infection on them, we performed RNA-seq on two sets of samples: 1)human ES cell line HuES8 and the trophoblast cells differentiated. 2)trophoblast cells infected at 4 days after differentiation by MOCK and ZIKV, and harvested 72hpi. Here, we demonstrate gene expression profile of trophoblasts derived from human ESCs is similar to the trophoectoderm cells isolated from human blastocysts. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
5 Samples

Download data: XLS

Series

Accession:: GSE133396

ID:: 200133396

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001332542.

Effect of ZIKV on pre-implantation embryos

(Submitter supplied) To determine the effect of Zika virus infection on pre-implantation embryonic development, we performed single blastocyst RNA-Seq on MOCK and ZIKV infected embryos. ZIKV infection results in an increased risk of spontaneous abortion and poor intrauterine growth although the mechanisms underlying fetal loss remain undetermined. Little is known about the impact of ZIKV infection during the earliest stages of pregnancy, or pre- and peri-implantation, because most current studies of ZIKV infection in pregnancy models focus on post-implantation stages. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
12 Samples

Download data: XLSX

Series

Accession:: GSE133254

ID:: 200133254

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000816373.

Transcriptome analysis of virus infected tissues

(Submitter supplied) We report the application of RNA sequencing for transcriptome analysis of virus infected tissues, enabling the study of tissue responses to infection

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: CSV

Series

Accession:: GSE81637

ID:: 200081637

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000890694.

Next Generation Sequencing Facilitates Quantitative Analysis of brain Transcriptome after viral infection with ZIKV (Zika Virus)

(Submitter supplied) Purpose: The goals of this study are to understand ZIKV induced immune responses in the developing brain at genome-wide level. Methods: Total RNA was isolated from E17.5 mouse brains after viral infection at E14.5. After genomic DNA and ribosomal RNA removal, fractionated RNA were subjected to strand-specific library preparation using NEBNext Ultra RNA Library Prep Kit. Sequencing was performed on Nextseq500 (Illumina). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: BW

Series

Accession:: GSE89069

ID:: 200089069

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002297025.

Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids

(Submitter supplied) Zika virus (ZIKV) infection during pregnancy results in an increased risk of spontaneous abortion and vertical transmission across placenta results in severe congenital defects in newborns. While the infectivity and pathological effects of ZIKV on the placental trophoblast progenitor cells in early human embryos remains largely unknown. Here, using the human trophoblast stem cells (hTSCs) isolated from human blastocyst, we showed that hTSCs were permissive to ZIKV infection, while resistance to ZIKV increased with differentiation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
3 Samples

Download data: MTX, TSV

Series

Accession:: GSE229702

ID:: 200229702

PubMed Full text in PMC Similar studies

Select item 2001931956.

Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts [miRNA-seq]

(Submitter supplied) Zika virus (ZIKV) infection at the maternal-placental interface is associated with adverse pregnancy outcomes including fetal demise and pregnancy loss. To determine how infection impacts placental trophoblasts, we utilized rhesus macaque trophoblast stem cells (TSC) that can be directed to differentiate into early gestation syncytiotrophoblasts (ST) and extravillous trophoblasts (EVT). TSCs and STs, but not EVTs, were highly permissive to productive infection with ZIKV strain DAK AR 41524. more...

Organism:: Macaca mulatta

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL19129
48 Samples

Download data: XLSX

Series

Accession:: GSE193195

ID:: 200193195

PubMed Full text in PMC Similar studies

Select item 2001852917.

Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts

Organism:: Macaca mulatta

Type:: Expression profiling by high throughput sequencing

Platform:: GPL27943
8 Samples

Download data: SF

Series

Accession:: GSE185291

ID:: 200185291

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001851138.

Rhesus macaque early-gestation trophoblast cells are permissive to Zika virus infection and viral exposure altered extracellular vesicle cargo

(Submitter supplied) Zika virus (ZIKV) infection of maternal and placental cells at the maternal-fetal interface is associated with a spectrum of adverse pregnancy outcomes including fetal demise and pregnancy loss. Trophoblast cell types that comprise the placenta include cytotrophoblasts, syncytiotrophoblasts (STs), and extravillous trophoblasts (EVTs). To determine which trophoblast cells are permissive to ZIKV and to understand how infection impacts cellular gene expression, we utilized a macaque in vitro trophoblast stem cell (TSC) model. more...

Organism:: Macaca mulatta

Type:: Expression profiling by high throughput sequencing

Platform:: GPL27943
24 Samples

Download data: CSV

Series

Accession:: GSE185113

ID:: 200185113

PubMed Full text in PMC Similar studies SRA Run Selector

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Links from GEO DataSets

Items: 8

Send to:

Supplemental Content

Find related data

Important Links

Recent activity