GEO DataSets

(Submitter supplied) Streptomyces albus S12, TK and Tet30Chl25 are the parental strain , low-yield and high-yield of salinomycin mutant obtained by ARTP and ribosome engineering ,respectively. There are total 1602 differentially expressed genes (DEGs) show differences in expression between the mutant strain TK, Tet30Chl25 and the initial strain S12. KEGG pathway analysis of differentially expressed genes (DEGs) between the mutant strain TK, Tet30Chl25 and the initial strain S12 show that the relevant differential pathways affecting salinomycin production were mainly related to butanoate metabolism, starch and sucrose metabolism, glyoxylate metabolism. more...

Organism:

Streptomyces albus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21996

3 Samples

Download data: TXT

(Submitter supplied) The differences between the ΔrspA1 mutant and the original strain A30 transcriptomes were analyzed at 30h in ferentaion cultures complemented with 75mM glutamate when the conditions preceding the differences observed in glucose consumption rate,pH and cell dry weight.

Organism:

Streptomyces albus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21996

4 Samples

Download data: TXT

(Submitter supplied) Streptomyces sp. are a rich source for natural products with recognized industrial value, explaining the high interest to improve and streamline production in these microbes. Here, we studied the production of pamamycins, macrodiolide homologues with a high activity against multi-resistant pathogenic microbes, using recombinant S. albus J1074/R2. Talc particles of micrometer size added to submerged cultures of the recombinant strain tripled pamamycin production up to 50 mg L­-1­. more...

Organism:

Streptomyces albidoflavus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28915

11 Samples

Download data: TXT

(Submitter supplied) Investigation of whole genome gene expression level changes in Streptomyces avermitilis delta-aveI mutant, compared to the wild-type strain. The mutants analyzed in this study are further described in Chen L, Lu Y., Chen J, Zhang W, Shu D, Qin Z, Yang S, Jiang W. (2008) Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. Appl Microbiol Biotechnol 80(2): 277-86.

Organism:

Streptomyces avermitilis

Type:

Expression profiling by array

Platform:

GPL8780

6 Samples

Download data: PAIR