Similar studies for GEO DataSets (Select 200138742) - GEO DataSets

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Items: 20

Select item 2001387421.

LIN28B Regulates Transcription and Potentiates MYCN-induced Neuroblastoma in a let-7-independent Manner [ChIP-seq]

(Submitter supplied) LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis at least in part through inhibition of let-7 microRNA biogenesis. Here, we report that overexpression of either wild-type LIN28B, or a LIN28B mutant that is unable to bind and inhibit let-7, accelerates the onset and increases the penetrance of MYCN-induced neuroblastoma, potentiates the invasion and migration of transformed sympathetic neuroblasts and drives the distant metastases in vivo. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
11 Samples

Download data: WIG

Series

Accession:: GSE138742

ID:: 200138742

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001387432.

LIN28B Regulates Transcription and Potentiates MYCN-induced Neuroblastoma in a let-7-independent Manner

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
22 Samples

Download data: WIG

Series

Accession:: GSE138743

ID:: 200138743

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Select item 2001387413.

LIN28B Regulates Transcription and Potentiates MYCN-induced Neuroblastoma in a let-7-independent Manner [RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
11 Samples

Download data: CSV

Series

Accession:: GSE138741

ID:: 200138741

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Select item 2000164764.

Integrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma

(Submitter supplied) mRNA profiles of thousands of human tumors are available, but methods to deduce oncogenic signaling networks from these data lag behind. It is especially challenging to identify main-regulatory routes, and to generalize conclusions obtained from experimental models. We designed the bioinformatic platform R2 in parallel with a wet-lab approach of neuroblastoma. Here we demonstrate how R2 facilitates an integrated analysis of our neuroblastoma data. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
88 Samples

Download data: CEL

Series

Accession:: GSE16476

ID:: 200016476

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Select item 2000815005.

Multiple mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
19 Samples

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Series

Accession:: GSE81500

ID:: 200081500

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Select item 2000814996.

Multiple mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma [shortRNA]

(Submitter supplied) The let-7 microRNA families are tumor suppressors often deregulated in cancer, yet the underlying mechanisms of let-7 disruption remain poorly understood. Neuroblastoma is defined in part by poor prognosis associated with genetic amplification of MYCN, itself a let-7 target. The let-7 biogenesis inhibitor LIN28B has been implicated as a critical regulator of MYCN ; however, here we show that LIN28B is dispensable for both MYCN protein expression and growth of MYCN amplified neuroblastoma cell lines despite robust de-repression of let-7 . more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: CSV

Series

Accession:: GSE81499

ID:: 200081499

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Select item 2000814987.

Multiple mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma [longRNA]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
9 Samples

Download data: CSV

Series

Accession:: GSE81498

ID:: 200081498

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Select item 2000814978.

Multiple mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma [Let7Targets]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: CSV

Series

Accession:: GSE81497

ID:: 200081497

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Select item 2000727219.

Effects of MYCN knockdwon on miRNA expression in neuroblastoma cells

(Submitter supplied) Global miRNAs expression profilling of SK-N-BE(2)-C cells after dsRNA-mediated knockdown of MYCN

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: TXT

Series

Accession:: GSE72721

ID:: 200072721

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Select item 20007264010.

Genome-wide mapping of MYCN binding in neuroblastoma cells

(Submitter supplied) To identify the MYCN transcription factor binding sites across the genome, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) using anti-MYCN and anti-IgG antibodies on a MYCN-amplified NB cell line, SK-N-BE(2)-C.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
2 Samples

Download data: BED, TXT

Series

Accession:: GSE72640

ID:: 200072640

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009008711.

LMO1 Synergizes with MYCN to Promotes Neuroblastoma Initiation and Metastasis

(Submitter supplied) High levels of LMO1 expression synergizes with MYCN to accelerate neuroblastomagenesis, enhance disease penetrance and promote widespread metastasis in zebrafish. Transcriptomic analysis of human neuroblasotma cells with programed expression of LMO1 vs vector control or neuroblastoma cells with differential endogenous LMO1 expression revealed that gene signitures affecting tumor cell-extracellular matrix interaction are significantly associated with high levels of LMO1 expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE90087

ID:: 200090087

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Select item 20007462612.

Differential gene expression in neuroblastoma cells after transfection with control siRNA, MYCN siRNA or TFAP4 siRNA.

(Submitter supplied) We analyed the gene expression profiles after knocking down MYCN or TFAP4. Results showed that transcription factor MYCN and TFAP4 commonly regulats a subset of genes that may contribute to neuroblastoma cells proliferation and migration.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE74626

ID:: 200074626

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Select item 20013276013.

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
10 Samples

Download data: TXT

Series

Accession:: GSE132760

ID:: 200132760

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Select item 20013269814.

RNA-seq analysis after knockdown of ASCL1 gene in Kelly cells

(Submitter supplied) RNA-seq analysis was performed in Kelly neuroblastoma cell line to analyze gene expression changes after ASCL1 knockdown.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
4 Samples

Download data: TXT

Series

Accession:: GSE132698

ID:: 200132698

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Select item 20013074715.

Gene expression profile of human neuroblastoma cell line SHSY-5Y after LMO1 knockdown

(Submitter supplied) To dissect molecular pathways regulated by LMO1 in neuroblastoma, we performed microarray gene expression profiling in a neuroblastoma cells (SHSY-5Y) after LMO1 knockdown.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE130747

ID:: 200130747

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Select item 20012007416.

ASCL1 is directly activated by the LMO1 and MYCN oncogenes and is a master regulator of the differentiation program in neuroblastoma

(Submitter supplied) Neuroblastoma is an embryonal tumor of the peripheral sympathetic nervous system. Elevated expression of the transcription factor LMO1 and the polymorphisms within this gene are associated with the susceptibility to develop neuroblastoma. LMO1 has been implicated as an oncogene in T-cell acute lymphoblastic leukemia; however, the transcriptional targets regulated by this protein in neuroblastoma cells are unknown. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
5 Samples

Download data: BEDGRAPH

Series

Accession:: GSE120074

ID:: 200120074

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Select item 20011882317.

RNA-seq analysis after LMO1 or MYCN knockdown in Kelly cells

(Submitter supplied) RNA-seq analysis was performed in Kelly neuroblastoma cell line to analyze gene expression changes after LMO1 or MYCN knockdown.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
6 Samples

Download data: TXT

Series

Accession:: GSE118823

ID:: 200118823

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Select item 20015030318.

An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

(Submitter supplied) To achieve the very high oncoprotein levels required to drive the malignant state, cancer cells utilise the ubiquitin proteasome system to regulate proteins involved in growth signalling pathways. Here we identify a transcriptional coactivator, ALYREF, expressed from the most common genetic copy number variation in childhood neuroblastoma, chromosome 17q21-ter gain. We show strong co-operativity between ALYREF and MYCN from transgenic models of neuroblastoma in vitro and in vivo. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
2 Samples

Download data: BW, TXT

Series

Accession:: GSE150303

ID:: 200150303

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Select item 20012557619.

RACS: Rapid Analysis of ChIP-Seq data for contig based genomes

(Submitter supplied) The biological samples are from untagged Tetrahymena thermophila to be used as a control for unspecific binding. Whole cells extracts were crosslinked and immunoprecipitated using M2 affinity gel (Sigma). The obtained DNA was sequenced by HiSeq2500 (Illumina). The processed fastq files were analyzed by RACS that segregates the found read accumulations between genic and intergenic regions being highly efficient for rapid downstream analyses.

Organism:: Tetrahymena thermophila

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL23968
8 Samples

Download data: CSV

Series

Accession:: GSE125576

ID:: 200125576

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20025280620.

A multi-omics approach reveals enrichment in metabolites involved in the regulation of the glutathione pathway in LIN28B-dependent cancer cells.

(Submitter supplied) The RNA-binding protein LIN28B, identified as an independent risk factor in high-risk neuroblastoma patients, is implicated in adverse treatment outcomes linked to metastasis and chemoresistance. Despite its clinical significance, the impact of LIN28B on neuroblastoma cell metabolism remains unexplored. This study employs a multi-omics approach, integrating transcriptome and metabolome data, to elucidate the global metabolic program associated with varying LIN28B expression levels over time. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23159
24 Samples

Download data: CEL

Series

Accession:: GSE252806

ID:: 200252806

PubMed Full text in PMC Similar studies Analyze with GEO2R

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