GEO DataSets

(Submitter supplied) Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are uncommon and still underestimated. Public DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to verify if 19p loss is significantly over-represented in children and adolescents. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined and corrected by Bonferroni’s method. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL10123

24 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Genome variation profiling by array

4 related Platforms

208 Samples

Download data: TXT

(Submitter supplied) Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are uncommon and still underestimated. Public DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to verify if 19p loss is significantly over-represented in children and adolescents. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined and corrected by Bonferroni’s method. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL16237

62 Samples

Download data: TXT

(Submitter supplied) Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are uncommon and still underestimated. Public DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to verify if 19p loss is significantly over-represented in children and adolescents. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined and corrected by Bonferroni’s method. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL5477

103 Samples

Download data: TXT

(Submitter supplied) Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are uncommon and still underestimated. Public DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to verify if 19p loss is significantly over-represented in children and adolescents. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined and corrected by Bonferroni’s method. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL2879

17 Samples

Download data: TXT

(Submitter supplied) Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are uncommon and still underestimated. Public DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to verify if 19p loss is significantly over-represented in children and adolescents. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined and corrected by Bonferroni’s method. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL2879

2 Samples

Download data: TXT

(Submitter supplied) The specific genes that influence neuroblastoma biology and are targeted by genomic alterations remain largely unknown. We quantified mRNA expression in a highly annotated series of 101 prospectively collected diagnostic neuroblastoma primary tumors and the expression profiles were determined using Affymetrix U95Av2 arrays. Comparisons between the sample groups allow the identification of genes with localized expression patterns. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8300

102 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by SNP array; SNP genotyping by SNP array

Platforms:

GPL2004 GPL570

53 Samples

Download data: CEL

(Submitter supplied) Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations. Genomic copy number losses and gains had been delineated in the tumours using FISH and SNP arrays. We have identified genes significantly altered by 7 recurrent alterations: 1p, 3p, 4p, 10q and 11q loss, 2p and 17q gain, and genes co-amplified and over-expressed as a result of MYCN amplification. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL2004

23 Samples

Download data: CEL

(Submitter supplied) Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations. Genomic copy number losses and gains had been delineated in the tumours using FISH and SNP arrays. We have identified genes significantly altered by 7 recurrent alterations: 1p, 3p, 4p, 10q and 11q loss, 2p and 17q gain, and genes co-amplified and over-expressed as a result of MYCN amplification. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

30 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:

GPL570 GPL10123

9 Samples

Download data: CEL, TXT

(Submitter supplied) Primary SCEC is a rare malignancy without established treatment strategy. Although previous studies suggested that there were similarities between SCEC and SCLC in clinical manifestation and pathological morphology, genetic studies on this highly malignant tumour remains sparse. This study was designed to investigate the copy number variations (CNVs) of SCEC.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL10123

3 Samples

Download data: TXT

(Submitter supplied) Primary SCEC is a rare malignancy without established treatment strategy. Although previous studies suggested that there were similarities between SCEC and SCLC in clinical manifestation and pathological morphology, genetic studies on this highly malignant tumour remained sparse. This study was designed to investigate the gene expression profile of SCEC, and compare it with the known expression data of SCLC and EC.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data: CEL

(Submitter supplied) Chromosomal instable colorectal cancer is marked by specific large chromosomal copy number aberrations. Recently, focal aberrations of 3Mb or smaller have been identified as a common phenomenon in cancer. Inherent to their limited size, these aberrations harbour one or few genes. The aim of this study is to identify recurrent focal chromosomal aberrations and their candidate driver genes in a well defined series of stage II colon cancers and assess their potential clinical relevance. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array; Expression profiling by array

4 related Platforms

61 Samples

Download data: PAIR, TXT

(Submitter supplied) Single-color gene expression profiles from 3 neuroblastoma cell lines were generated using 44K oligonucleotide microarrays. To gain insights into the molecular processes occurring upon FOXP1 re-expression, we performed series of time-resolved gene expression measurements in FOXP1 and GFP transgenic neuroblastoma cell lines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16876

24 Samples

Download data: TXT

(Submitter supplied) Neuroblastoma (NB) is an aggressive tumor that affects both infants and children. The disease outcome is greatly influenced by age of patient, stage, chromosome copy number aberrations (CNAs) and gene expression abnormalities. We analyzed, by microarray technology, genome and transcriptome of 3 groups of tumors of patients with metastatic disease: G1, stage 4S and MYCN single copy; G2, stage 4 younger than 18 months of age, MYCN single copy with no disease progression and G3, stage 4, older than 19 months, with unfavorable outcome. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

4 related Platforms

133 Samples

Download data: TXT

(Submitter supplied) We conducted microarray-based comparative genomic hybridization (array-CGH) with a DNA chip carrying 2,464 BAC clones to examine genomic aberrations of 236 neuroblastomas (112 sporadic and 124 mass screening-detected). In paralell, gene-expression profiling was also performed by using in-house cDNA microarrays. Keywords: Comparative genomic hybridization

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL4242

236 Samples

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