Similar studies for GEO DataSets (Select 200145820) - GEO DataSets

Select item 2001458201.

Structural cells are key regulators of organ-specific immune response

(Submitter supplied) The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens. Its main actors are hematopoietic immune cells, including myeloid cells with their focus on innate immunity and lymphoid cells as enablers of adaptive immunity. Nevertheless, immune functions are not unique to hematopoietic cells, and basic mechanisms of pathogen defense are present in many other cell types. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
230 Samples

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Series

Accession:: GSE145820

ID:: 200145820

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Select item 2001346632.

Structural cells are key regulators of organ-specific immune response

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
579 Samples

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Series

Accession:: GSE134663

ID:: 200134663

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Select item 2001346593.

Structural cells are key regulators of organ-specific immune response

(Submitter supplied) The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens. Its main actors are hematopoietic immune cells, including myeloid cells with their focus on innate immunity and lymphoid cells as enablers of adaptive immunity. Nevertheless, immune functions are not unique to hematopoietic cells, and basic mechanisms of pathogen defense are present in many other cell types. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
208 Samples

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Series

Accession:: GSE134659

ID:: 200134659

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Select item 2001346584.

Structural cells are key regulators of organ-specific immune response

(Submitter supplied) The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens. Its main actors are hematopoietic immune cells, including myeloid cells with their focus on innate immunity and lymphoid cells as enablers of adaptive immunity. Nevertheless, immune functions are not unique to hematopoietic cells, and basic mechanisms of pathogen defense are present in many other cell types. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
71 Samples

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Series

Accession:: GSE134658

ID:: 200134658

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Select item 2001346485.

Structural cells are key regulators of organ-specific immune response

(Submitter supplied) The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens. Its main actors are hematopoietic immune cells, including myeloid cells with their focus on innate immunity and lymphoid cells as enablers of adaptive immunity. Nevertheless, immune functions are not unique to hematopoietic cells, and basic mechanisms of pathogen defense are present in many other cell types. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
70 Samples

Download data: CSV

Series

Accession:: GSE134648

ID:: 200134648

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Select item 2001267706.

Natural genetic variation reveals key features of epigenetic and transcriptional memory in virus-specific CD8 T cells

(Submitter supplied) Stable changes in chromatin states and gene expression in cells of the immune system form the basis for their memory of infections and other challenges. We used naturally occurring cis-regulatory variation in wild-derived inbred mouse strains to explore the mechanisms underlying long-lasting vs. transient gene regulation in antigen-specific CD8 T cells responding to acute viral infection. Our observations provide novel insights into the mechanisms driving stable and reversible transcriptional and epigenetic memory in virus-specific CD8 T cells. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL21103 GPL17021
70 Samples

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Series

Accession:: GSE126770

ID:: 200126770

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Select item 2000159077.

ImmGen Microarray Phase 1

(Submitter supplied) Gene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen). Primary cells from multiple immune lineages are isolated ex-vivo, primarily from young adult B6 male mice, and double-sorted to >99% purity. RNA is extracted from cells in a centralized manner, amplified and hybridized to Affymetrix 1.0 ST MuGene arrays. Protocols are rigorously standardized for all sorting and RNA preparation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
653 Samples

Download data: CEL

Series

Accession:: GSE15907

ID:: 200015907

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002185938.

Spatial epigenome-transcriptome co-profiling of mammalian tissues

(Submitter supplied) We present spatially resolved high-spatial-resolution genome-wide co-mapping of epigenome and transcriptome by simultaneously profiling of chromatin accessibility and gene expression (spatial-ATAC-RNA-seq), as well as histone modification and gene expression (spatial-CUT&Tag-RNA-seq) on the same tissue section at cellular level by combining the microfluidic deterministic barcoding strategy in DBiT-seq and the chemistry used in ATAC-seq/CUT&Tag.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: TAR, TSV

Series

Accession:: GSE218593

ID:: 200218593

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Select item 2002170919.

Spatial epigenome-transcriptome co-profiling of mammalian tissues [spatial CUT&Tag]

(Submitter supplied) We present spatially resolved high-spatial-resolution genome-wide co-mapping of epigenome and transcriptome by simultaneously profiling of chromatin accessibility and gene expression (spatial-ATAC-RNA-seq), as well as histone modification and gene expression (spatial-CUT&Tag-RNA-seq) on the same tissue section at cellular level by combining the microfluidic deterministic barcoding strategy in DBiT-seq and the chemistry used in ATAC-seq/CUT&Tag.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: TSV

Series

Accession:: GSE217091

ID:: 200217091

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Select item 20020518110.

Spatial epigenome-transcriptome co-profiling of mammalian tissues [Human RNA-Seq]

(Submitter supplied) We present spatially resolved high-spatial-resolution genome-wide co-mapping of epigenome and transcriptome by simultaneously profiling of chromatin accessibility and gene expression (spatial-ATAC-RNA-seq), as well as histone modification and gene expression (spatial-CUT&Tag-RNA-seq) on the same tissue section at cellular level by combining the microfluidic deterministic barcoding strategy in DBiT-seq and the chemistry used in ATAC-seq/CUT&Tag.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
1 Sample

Download data: TAR, TSV

Series

Accession:: GSE205181

ID:: 200205181

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Select item 20020518011.

Spatial epigenome-transcriptome co-profiling of mammalian tissues [Human ATAC-Seq]

(Submitter supplied) We present spatially resolved high-spatial-resolution genome-wide co-mapping of epigenome and transcriptome by simultaneously profiling of chromatin accessibility and gene expression (spatial-ATAC-RNA-seq), as well as histone modification and gene expression (spatial-CUT&Tag-RNA-seq) on the same tissue section at cellular level by combining the microfluidic deterministic barcoding strategy in DBiT-seq and the chemistry used in ATAC-seq/CUT&Tag.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
1 Sample

Download data: TAR, TSV

Series

Accession:: GSE205180

ID:: 200205180

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Select item 20020505512.

Spatial epigenome-transcriptome co-profiling of mammalian tissues

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24676 GPL24247
22 Samples

Download data: TAR, TSV

Series

Accession:: GSE205055

ID:: 200205055

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Select item 20020505413.

Spatial epigenome-transcriptome co-profiling of mammalian tissues [RNA-Seq]

(Submitter supplied) We present spatially resolved high-spatial-resolution genome-wide co-mapping of epigenome and transcriptome by simultaneously profiling of chromatin accessibility and gene expression (spatial-ATAC-RNA-seq), as well as histone modification and gene expression (spatial-CUT&Tag-RNA-seq) on the same tissue section at cellular level by combining the microfluidic deterministic barcoding strategy in DBiT-seq and the chemistry used in ATAC-seq/CUT&Tag.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: TAR, TSV

Series

Accession:: GSE205054

ID:: 200205054

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Select item 20020505214.

Spatial epigenome-transcriptome co-profiling of mammalian tissues [ATAC-Seq]

(Submitter supplied) We present spatially resolved high-spatial-resolution genome-wide co-mapping of epigenome and transcriptome by simultaneously profiling of chromatin accessibility and gene expression (spatial-ATAC-RNA-seq), as well as histone modification and gene expression (spatial-CUT&Tag-RNA-seq) on the same tissue section at cellular level by combining the microfluidic deterministic barcoding strategy in DBiT-seq and the chemistry used in ATAC-seq/CUT&Tag.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
5 Samples

Download data: TAR, TSV

Series

Accession:: GSE205052

ID:: 200205052

PubMed Full text in PMC Similar studies

Select item 20020505115.

Spatial epigenome-transcriptome co-profiling of mammalian tissues [CUT&TAG]

(Submitter supplied) We present spatially resolved high-spatial-resolution genome-wide co-mapping of epigenome and transcriptome by simultaneously profiling of chromatin accessibility and gene expression (spatial-ATAC-RNA-seq), as well as histone modification and gene expression (spatial-CUT&Tag-RNA-seq) on the same tissue section at cellular level by combining the microfluidic deterministic barcoding strategy in DBiT-seq and the chemistry used in ATAC-seq/CUT&Tag.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
1 Sample

Download data: TAR, TSV

Series

Accession:: GSE205051

ID:: 200205051

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Select item 20004389616.

Comparison of monocytic cells from naïve mice and day 14 LCMV Armstrong and day 14 LCMV Clone 13 infected mice

(Submitter supplied) Infection with acute and chronic strains of LCMV (Armstrong (ARM) and Clone 13 (C13), respectively) leads to massive proliferation of monocytic cells contemporaneously with peak of the anti-viral CD8+ T cell response. These cells return to naïve levels following ARM infection. However, during C13 infection these cells are sustained at high levels and gain a T cell suppressive function at day 14 post infection. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
9 Samples

Download data: TXT

Series

Accession:: GSE43896

ID:: 200043896

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011398017.

CD47 expression in natural killer cell regulates homeostasis and modulates immune response to lymphocytic choriomeningitis virus

(Submitter supplied) CD47 is a ubiquitous cell surface receptor that limits cell clearance by phagocytes that express its counter-receptor signal-regulatory protein-α and directly regulates T cell immunity by interacting with its inhibitory ligand thrombospondin-1. Murine natural killer (NK) cells express higher levels of CD47 than other lymphocytes, but the role of CD47 in regulating NK cell homeostasis and immune function remains unclear. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
27 Samples

Download data: TXT

Series

Accession:: GSE113980

ID:: 200113980

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Select item 20008884018.

Conversion of adult endothelium to immunocompetent haematopoietic stem cells

(Submitter supplied) Developmental pathways that orchestrate the fleeting transition of endothelial cells into haematopoietic stem cells remain undefined. Here we demonstrate a tractable approach for fully reprogramming adult mouse endothelial cells to haematopoietic stem cells (rEC-HSCs) through transient expression of the transcription-factor-encoding genes Fosb, Gfi1, Runx1, and Spi1 (collectively denoted hereafter as FGRS) and vascular-niche-derived angiocrine factors. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
30 Samples

Download data: TSV

Series

Accession:: GSE88840

ID:: 200088840

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Select item 20005980319.

Epigenetic and molecular signatures of cord blood CD34(+) cells treated with histone deacetylase inhibitors

(Submitter supplied) Gene expression profiling of primary cord blood hematopoietic stem cell (day 0, CD34+ cells), enriched control (untreated), Scriptaid and Valproic acid expanded CD34+ cells after a week in culture. Cord blood CD34+ cells were processed individually and equal number of PC and reisolated CD34+ cells from 3-4 samples were pooled after expansion to avoid sample variations.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
8 Samples

Download data: TXT

Series

Accession:: GSE59803

ID:: 200059803

Select item 20013203320.

Tox reinforces the phenotype and longevity of dysfunctional T cell populations during chronic viral infection [WT vs KO +/- Tim3]

(Submitter supplied) Chronic CD8 T-cell stimulation in persisting infections or tumors can induce a stable gene expression program, known as T-cell dysfunction or exhaustion, that limits the cell’s effector functions and anti-viral and anti-tumor immunity. Thus far, the underlaying molecular mechanisms that induce and stabilize this phenotype are vaguely understood. We report here that establishing this program requires the thymocyte selection-associated high mobility group-box protein (Tox). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
20 Samples

Download data: TXT

Series

Accession:: GSE132033

ID:: 200132033

PubMed Similar studies SRA Run Selector

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