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Links from GEO DataSets

Items: 19

1.

T-cell acute lymphobalstic leukemia xenografts in NOD/SCID mouse

(Submitter supplied) Gene expression analysis of twenty patient-derived T-ALL xenografts was performed to determine if a GLI activation signature was enriched in GANT-61 sensitive cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14550
20 Samples
Download data: TXT, XLSX
Series
Accession:
GSE153717
ID:
200153717
2.

Cross-talk between GLI transcription factors and FOXC1 promotes T-cell acute lymphoblastic leukemia dissemination

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL14550
26 Samples
Download data: TXT
Series
Accession:
GSE153750
ID:
200153750
3.

Next Generation Sequencing (RNA sequencing) of Wild Type and GLI1 knock-out CUTLL1 childhood T lymphoblastic lymphoma cell line

(Submitter supplied) T-cell acute lymphoblastic leukemia (T-ALL) is a highly malignant pediatric leukemia, where few therapeutic options are available for patients which relapse. The evolutionarily conserved Hedgehog (Hh) pathway plays a crucial role in patterning and organogenesis during early development, in adult tissue maintenance and repairing functions. Once Hh ligands bind to PTCH1/2 on target cells, the inhibition of Patched proteins for Smo is relieved. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE153718
ID:
200153718
4.

ChIP-seq for Gli1 and Gli2 in chondrosarcoma

(Submitter supplied) Excessive Hedgehog signaling in chondrocytes is sufficient to cause formation of enchondroma-like lesions in mice which can progress to chondrosarcoma. To elucidate potential mechanisms through which activation of Hedgehog signaling contributes to cartilage tumor formation, we used chromatin immunoprecipitation and next generation sequencing to identify Gli1 and Gli2 target genes in primary human chondrosarcoma. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9115
3 Samples
Download data: BW
Series
Accession:
GSE100936
ID:
200100936
5.

The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway

(Submitter supplied) ZNF521 is a transcription co-factor with recognized regulatory functions in haematopoietic, osteo-adipogenic and neural progenitor cells. Among its diverse activities, ZNF521 has been implicated in the regulation of medulloblastoma (MB) cells, where the Hedgehog (HH) pathway, has a key role in the development of normal cerebellum and of a substantial fraction of MBs. Here a functional cross-talk is shown for ZNF521 with the HH pathway, where it interacts with GLI1 and GLI2, the major HH transcriptional effectors and enhances the activity of HH signalling. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
4 Samples
Download data: TXT
6.

GLI1-regulated genes in human mammary epithelial cells and human breast cancer cells

(Submitter supplied) To clarify transcriptional target genes of GLI1 in human mammary epithelial cells and breast cancer cells, primary culture cells of human mammary epithelium HMEC and breast cancer cell line MCF-7 were lentivirally transduced by either GLI1 or its control LacZ. Their RNA samples were served for expression analysis using AGILENT human 8x60K cDNA microarray.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
4 Samples
Download data: TXT
Series
Accession:
GSE64350
ID:
200064350
7.

Transcriptome analysis of a FACS-sorted human intersitial cells of Cajal (ICC) [array]

(Submitter supplied) Interstitial cells of Cajal (ICC) are electrical pacemakers and mediators of neuromuscular neurotransmission in the gastrointestinal tract. Gastrointestinal stromal tumors (GIST) arise within the ICC lineage due to activating KIT/PDGFRA mutations. In this study we developed a method for isolation of human ICC by immunolabeling and fluorescence-activated cell sorting (FACS). Briefly, human gastric musculature was dissociated and incubated with antibodies against CD45, FCER1A, CD11B, KIT, and CD34. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
14 Samples
Download data: CEL
Series
Accession:
GSE77839
ID:
200077839
8.

Downstream genes regulated by TSHZ2 in MCF-7 cells

(Submitter supplied) To clarify downstream genes regulated by TSHZ2, MCF-7 cells were lentivirally transduced by TSHZ2 and its control LacZ and served their RNA samples for gene expression analysis using AGILENT human 8x60K cDNA microarray.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
2 Samples
Download data: TXT
Series
Accession:
GSE64351
ID:
200064351
9.

Expression data from GLI1-transformed RK3E cells

(Submitter supplied) SHH signaling pathway is activated in many type of cancers. However, the role of its activation in particular type of cancer was poorly understood. The GLI family transcription factor GLI1 is the effector of Shh pathway activation and functions as oncogene. Our goal of research is to identify the GLI1 targets in desmoplastic medulloblastomas. We used microarrays to obtain the global gene expression profiles in cells transformed by GLI1 and identified distinct classes of genes by comparing with those of desmoplastic medulloblastomas
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3550
Platform:
GPL1355
6 Samples
Download data: CEL
Series
Accession:
GSE11987
ID:
200011987
10.
Full record GDS3550

GLI1 transformed kidney epithelial cell line

Analysis of kidney epithelial RK3E cells transformed by the oncogenic transcription factor GLI1. Results compared with the gene expression profile of a subgroup of medulloblastomas that shows constitutive activation of the Sonic hedgehog pathway with expression of GLI1.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 cell type, 3 other sets
Platform:
GPL1355
Series:
GSE11987
6 Samples
Download data: CEL
11.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL18573 GPL16791
49 Samples
Download data: TSV
Series
Accession:
GSE149350
ID:
200149350
12.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [WTvsDP mouse RNA-seq]

(Submitter supplied) Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synthesis via Wnt pathway for survival
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
7 Samples
Download data: TSV
Series
Accession:
GSE149349
ID:
200149349
13.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [mouse PKF RNA-seq]

(Submitter supplied) Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synthesis via Wnt pathway for survival
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: TSV, XLSX
Series
Accession:
GSE149348
ID:
200149348
14.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [TCF ChIP]

(Submitter supplied) Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synthesis via Wnt pathway for survival
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
2 Samples
Download data: TSV
Series
Accession:
GSE149347
ID:
200149347
15.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [primary tumor RNA-seq]

(Submitter supplied) Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synthesis via Wnt pathway for survival
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
20 Samples
Download data: TSV
16.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [human PKF RNA-seq]

(Submitter supplied) Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synthesis via Wnt pathway for survival
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
8 Samples
Download data: TSV
17.

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL24247 GPL24676
76 Samples
Download data: BED, BIGWIG, NARROWPEAK, TXT
Series
Accession:
GSE221345
ID:
200221345
18.

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress [ChIP-seq]

(Submitter supplied) Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL). But in clinical trials, pan-Notch inhibitors caused excessive toxicity. To find alternative ways to target Notch signals, we investigated Cell division cycle 73 (Cdc73), which is a component of the RNA polymerase-associated transcriptional machinery and has been previously described as a Notch cofactor. Emerging evidence also suggests that transcriptional machinery might be an attractive vulnerability in T-ALL. more...
Organism:
Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24247 GPL24676
40 Samples
Download data: BED, BIGWIG, TXT
Series
Accession:
GSE221339
ID:
200221339
19.

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress [Bru-seq and BruUV-seq]

(Submitter supplied) Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL). But in clinical trials, pan-Notch inhibitors caused excessive toxicity. To find alternative ways to target Notch signals, we investigated Cell division cycle 73 (Cdc73), which is a component of the RNA polymerase-associated transcriptional machinery and has been previously described as a Notch cofactor. Emerging evidence also suggests that transcriptional machinery might be an attractive vulnerability in T-ALL. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL24247
36 Samples
Download data: BED, BIGWIG, CSV, NARROWPEAK, XLSX
Series
Accession:
GSE219097
ID:
200219097
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