Similar studies for GEO DataSets (Select 200153750) - GEO DataSets

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Items: 19

Select item 2001537501.

Cross-talk between GLI transcription factors and FOXC1 promotes T-cell acute lymphoblastic leukemia dissemination

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL14550
26 Samples

Download data: TXT

Series

Accession:: GSE153750

ID:: 200153750

Select item 2001537182.

Next Generation Sequencing (RNA sequencing) of Wild Type and GLI1 knock-out CUTLL1 childhood T lymphoblastic lymphoma cell line

(Submitter supplied) T-cell acute lymphoblastic leukemia (T-ALL) is a highly malignant pediatric leukemia, where few therapeutic options are available for patients which relapse. The evolutionarily conserved Hedgehog (Hh) pathway plays a crucial role in patterning and organogenesis during early development, in adult tissue maintenance and repairing functions. Once Hh ligands bind to PTCH1/2 on target cells, the inhibition of Patched proteins for Smo is relieved. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE153718

ID:: 200153718

Select item 2001537173.

T-cell acute lymphobalstic leukemia xenografts in NOD/SCID mouse

(Submitter supplied) Gene expression analysis of twenty patient-derived T-ALL xenografts was performed to determine if a GLI activation signature was enriched in GANT-61 sensitive cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
20 Samples

Download data: TXT, XLSX

Series

Accession:: GSE153717

ID:: 200153717

Select item 2001009364.

ChIP-seq for Gli1 and Gli2 in chondrosarcoma

(Submitter supplied) Excessive Hedgehog signaling in chondrocytes is sufficient to cause formation of enchondroma-like lesions in mice which can progress to chondrosarcoma. To elucidate potential mechanisms through which activation of Hedgehog signaling contributes to cartilage tumor formation, we used chromatin immunoprecipitation and next generation sequencing to identify Gli1 and Gli2 target genes in primary human chondrosarcoma. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
3 Samples

Download data: BW

Series

Accession:: GSE100936

ID:: 200100936

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001589255.

The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway

(Submitter supplied) ZNF521 is a transcription co-factor with recognized regulatory functions in haematopoietic, osteo-adipogenic and neural progenitor cells. Among its diverse activities, ZNF521 has been implicated in the regulation of medulloblastoma (MB) cells, where the Hedgehog (HH) pathway, has a key role in the development of normal cerebellum and of a substantial fraction of MBs. Here a functional cross-talk is shown for ZNF521 with the HH pathway, where it interacts with GLI1 and GLI2, the major HH transcriptional effectors and enhances the activity of HH signalling. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: TXT

Series

Accession:: GSE158925

ID:: 200158925

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000643506.

GLI1-regulated genes in human mammary epithelial cells and human breast cancer cells

(Submitter supplied) To clarify transcriptional target genes of GLI1 in human mammary epithelial cells and breast cancer cells, primary culture cells of human mammary epithelium HMEC and breast cancer cell line MCF-7 were lentivirally transduced by either GLI1 or its control LacZ. Their RNA samples were served for expression analysis using AGILENT human 8x60K cDNA microarray.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
4 Samples

Download data: TXT

Series

Accession:: GSE64350

ID:: 200064350

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000778397.

Transcriptome analysis of a FACS-sorted human intersitial cells of Cajal (ICC) [array]

(Submitter supplied) Interstitial cells of Cajal (ICC) are electrical pacemakers and mediators of neuromuscular neurotransmission in the gastrointestinal tract. Gastrointestinal stromal tumors (GIST) arise within the ICC lineage due to activating KIT/PDGFRA mutations. In this study we developed a method for isolation of human ICC by immunolabeling and fluorescence-activated cell sorting (FACS). Briefly, human gastric musculature was dissociated and incubated with antibodies against CD45, FCER1A, CD11B, KIT, and CD34. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
14 Samples

Download data: CEL

Series

Accession:: GSE77839

ID:: 200077839

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000643518.

Downstream genes regulated by TSHZ2 in MCF-7 cells

(Submitter supplied) To clarify downstream genes regulated by TSHZ2, MCF-7 cells were lentivirally transduced by TSHZ2 and its control LacZ and served their RNA samples for gene expression analysis using AGILENT human 8x60K cDNA microarray.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
2 Samples

Download data: TXT

Series

Accession:: GSE64351

ID:: 200064351

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000119879.

Expression data from GLI1-transformed RK3E cells

(Submitter supplied) SHH signaling pathway is activated in many type of cancers. However, the role of its activation in particular type of cancer was poorly understood. The GLI family transcription factor GLI1 is the effector of Shh pathway activation and functions as oncogene. Our goal of research is to identify the GLI1 targets in desmoplastic medulloblastomas. We used microarrays to obtain the global gene expression profiles in cells transformed by GLI1 and identified distinct classes of genes by comparing with those of desmoplastic medulloblastomas

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3550
Platform:: GPL1355
6 Samples

Download data: CEL

Series

Accession:: GSE11987

ID:: 200011987

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 355010.

GLI1 transformed kidney epithelial cell line

Analysis of kidney epithelial RK3E cells transformed by the oncogenic transcription factor GLI1. Results compared with the gene expression profile of a subgroup of medulloblastomas that shows constitutive activation of the Sonic hedgehog pathway with expression of GLI1.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 cell type, 3 other sets

Platform:: GPL1355
Series:: GSE11987
6 Samples

Download data: CEL

DataSet

Accession:: GDS3550

ID:: 3550

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20014935011.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL18573 GPL16791
49 Samples

Download data: TSV

Series

Accession:: GSE149350

ID:: 200149350

PubMed Full text in PMC Similar studies

Select item 20014934912.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [WTvsDP mouse RNA-seq]

(Submitter supplied) Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synthesis via Wnt pathway for survival

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
7 Samples

Download data: TSV

Series

Accession:: GSE149349

ID:: 200149349

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014934813.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [mouse PKF RNA-seq]

(Submitter supplied) Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synthesis via Wnt pathway for survival

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TSV, XLSX

Series

Accession:: GSE149348

ID:: 200149348

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014934714.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [TCF ChIP]

(Submitter supplied) Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synthesis via Wnt pathway for survival

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: TSV

Series

Accession:: GSE149347

ID:: 200149347

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014934615.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [primary tumor RNA-seq]

(Submitter supplied) Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synthesis via Wnt pathway for survival

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
20 Samples

Download data: TSV

Series

Accession:: GSE149346

ID:: 200149346

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20014934516.

Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [human PKF RNA-seq]

(Submitter supplied) Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synthesis via Wnt pathway for survival

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
8 Samples

Download data: TSV

Series

Accession:: GSE149345

ID:: 200149345

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20022134517.

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL24247 GPL24676
76 Samples

Download data: BED, BIGWIG, NARROWPEAK, TXT

Series

Accession:: GSE221345

ID:: 200221345

PubMed Similar studies

Select item 20022133918.

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress [ChIP-seq]

(Submitter supplied) Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL). But in clinical trials, pan-Notch inhibitors caused excessive toxicity. To find alternative ways to target Notch signals, we investigated Cell division cycle 73 (Cdc73), which is a component of the RNA polymerase-associated transcriptional machinery and has been previously described as a Notch cofactor. Emerging evidence also suggests that transcriptional machinery might be an attractive vulnerability in T-ALL. more...