Similar studies for GEO DataSets (Select 200157210) - GEO DataSets

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Items: 20

Select item 2001572101.

p53 activation during ribosome biogenesis regulates normal erythroid differentiation.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL22936 GPL18573
26 Samples

Download data: CEL, WIG

Series

Accession:: GSE157210

ID:: 200157210

Select item 2001572082.

p53 activation during ribosome biogenesis regulates normal erythroid differentiation. [ChIP-Seq]

(Submitter supplied) The role of ribosome biogenesis in erythroid development is supported by the recognition of erythroid defects in ribosomopathies in both Diamond-Blackfan anemia and 5q- syndrome. Whether ribosome biogenesis exerts a regulatory function on normal erythroid development is still unknown. In the present study, a detailed characterization of ribosome biogenesis dynamics during human and murine erythropoiesis shows that ribosome biogenesis is abruptly interrupted by the drop of rDNA transcription and the collapse of ribosomal protein neo-synthesis. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: WIG

Series

Accession:: GSE157208

ID:: 200157208

PubMed Similar studies SRA Run Selector

Select item 2001379513.

p53 activation during ribosome biogenesis regulates normal erythroid differentiation. [expression]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL22936
22 Samples

Download data: CEL

Series

Accession:: GSE137951

ID:: 200137951

Select item 2000634134.

Murine Proerythroblasts (ProEs): WT vs. Bmi1-/-

(Submitter supplied) Transcriptional profiling of ProEs purified from wild type and Bmi1-/- mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7042
3 Samples

Download data: TXT

Series

Accession:: GSE63413

ID:: 200063413

PubMed Full text in PMC Similar studies

Select item 2000634115.

Murine Myeloid-Erythroid Progenitors (MEPs): WT vs. Bmi1-/-

(Submitter supplied) Transcriptional profiling of MEPs purified from wild type and Bmi1-/- mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7042
3 Samples

Download data: TXT

Series

Accession:: GSE63411

ID:: 200063411

PubMed Full text in PMC Similar studies

Select item 2001747296.

Analysis of gene expression change in cancer cells induced by nucleolar stress

(Submitter supplied) Accumulating evidence indicate that aberrantly increased ribosome biogenesis is a hallmark of cancer. As such, there is a growing interest in the development of strategies to target this pathway for cancer therapeutic. It is well established that inhibition of any steps of ribosome biogenesis induces a nucleolar stress characterized by p53 activation and subsequent cell cycle arrest and/or cell death. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
4 Samples

Download data: TXT

Series

Accession:: GSE174729

ID:: 200174729

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000894207.

Surveillance of rRNA synthesis by an RNA helicase mediates tissue-specific developmental disorders

(Submitter supplied) Myriad of craniofacial disorders are caused by heterozygous mutations in general regulators of housekeeping cellular functions such as ribosome biogenesis. While it is understood that many of these highly tissue-specific malformations are a consequence of defects in cranial neural crest cells (cNCCs), an embryonic cell group that gives rise to most of the facial structures during embryogenesis, the mechanism underlying cell type-selectivity of these effects remains largely unknown. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL16791
10 Samples

Download data: BW, WIG

Series

Accession:: GSE89420

ID:: 200089420

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001840028.

The mechanistic studies of GATA1 regulation of SREBP2 in G1-ER4 cells

(Submitter supplied) In our work, we uncovered a critical role for cholesterol homeostasis in terminal erythropoiesis. The master transcriptional factor GATA1 binds to Sterol-regulatory element binding protein 2 (SREBP2) to downregulate cholesterol biosynthesis, leading to a gradual reduction in intracellular cholesterol levels. To reveal genetic interactions and epistatic relations between GATA1 and SREBP2 on depth at the whole genome level, we performed RNA sequencing to analyze the gene expression profiles change between treated with Vehicle or β-estradiol in overexpressing active SREBP2 G1E-ER4 cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23479
12 Samples

Download data: TXT

Series

Accession:: GSE184002

ID:: 200184002

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001661539.

Quantitative Analysis of erythroblast cells Transcriptomes treated with cholesterol or not

(Submitter supplied) In our work, we explored the dynamics of cholesterol homeostasis during terminal erythropoiesis. Interestingly, we found differential requirements of cholesterol during terminal erythropoiesis, with that cholesterol is essential for the early stage erythroblasts proliferation, while the downregulation of cholesterol biosynthesis is required for late stage cell cycle exit and final enucleation. To reveal the role of cholesterol in the the early stage erythroblasts proliferation and the detail mechanisms of erythroblasts late stage cell cycle exit, we performed RNA sequencing to analyze the gene expression profiles change between untreated and cholesterol treated erythroblasts.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23479
6 Samples

Download data: TXT

Series

Accession:: GSE166153

ID:: 200166153

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006760910.

Runx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells

(Submitter supplied) The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1 mutations can be early events, creating pre-leukemic stem cells that expand in the bone marrow. Here we show that, counter-intuitively, Runx1 deficient hematopoietic stem and progenitor cells (HSPCs) have a slow growth, low biosynthetic, small cell phenotype and markedly reduced ribosome biogenesis (Ribi). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TXT

Series

Accession:: GSE67609

ID:: 200067609

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014423311.

RNAseq comparison of Whole crypt mRNA levels between Control, conditional Notchless KO, Apc KO and Notchless-Apc KO mice 24h or 48h after induction

(Submitter supplied) Control (Villin-CreERT2tg/0; Apcflox/+; Nleflox/+), ApccKO (Villin-CreERT2tg/0; Apcflox/flox; Nleflox/+) and ApccKO; NlecKO (Villin-CreERT2tg/0; Apcflox/flox; Nleflox/null) mice were subjected to three daily intraperitoneal tamoxifen injections and their intestinal crypts were harvested at 24h (d1) or 48h (d2) post last tamoxifen injection. Total RNA was extracted according to the Trizol-chloroform extraction protocol provided by Invitrogen. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
24 Samples

Download data: TSV

Series

Accession:: GSE144233

ID:: 200144233

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006008712.

Epo-Induced Erythroid Maturation Is Dependent on Plcγ1 Signaling

(Submitter supplied) Erythropoiesis is a tightly regulated process. Development of red blood cells occurs through differentiation of hematopoietic stem cells into more committed progenitors and finally into erythrocytes. Binding of erythropoietin to its receptor (EpoR) is strictly required for erythropoiesis as it promotes survival and late maturation of erythroid progenitors. In vivo and in vitro studies have highlighted the requirement of EpoR signaling through Jak2 tyrosine-kinase and Stat5a/b as a central pathway. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: BED

Series

Accession:: GSE60087

ID:: 200060087

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018305413.

RNA-Seq analysis of Rpl22l1-deficient murine CD4-CD-CD44-CD25+ (DN3) thymocytes

(Submitter supplied) Rpl22l1 is a highly conserved ribosomal protein paralog that plays a regulatory role in certain hematopoietic cell lineages. Rpl22l1-deficiency arrests the development of T cells at the DN3 stage. RNA-seq analysis was performed to identify the molecular basis for the arrest

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: XLSX

Series

Accession:: GSE183054

ID:: 200183054

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011351414.

Expression data from HCT116 cell transduced with lentivirus encoding PNO1 shRNA (sh-PNO1) or Control shRNA (sh-Ctrl)

(Submitter supplied) To further explore the underlying mechanism of PNO1 knockdown on suppression of CRC cell growth in vivo and in vitro, Affymetrix human GeneChip primeview arrays were performed to determine the global gene expression in HCT116 cells after transduction lentivirus encoding PNO1 shRNA (n=3) or control shRNA (n=3).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15207
6 Samples

Download data: CEL

Series

Accession:: GSE113514

ID:: 200113514

Select item 20000971715.

Rb Intrinsically Promotes Erythropoiesis by Coupling Cell Cycle Exit with Mitochondrial Biogenesis

(Submitter supplied) Regulation of the cell cycle is intimately linked to erythroid differentiation, yet how these processes are coupled is not well understood. To gain insight into this coordinate regulation, we examined the role that the retinoblastoma protein (Rb), a central regulator of the cell cycle, plays in erythropoiesis. We found that Rb serves a cell-intrinsic role and its absence causes ineffective erythropoiesis, with a differentiation block at the transition from early to late erythroblasts. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE9717

ID:: 200009717

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022361616.

Ribosome biogenesis controls suture mesenchymal stem cell fate via selective regulation of complement pathway in to prevent craniosynostosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL24676
8 Samples

Download data: TXT

Series

Accession:: GSE223616

ID:: 200223616

PubMed Full text in PMC Similar studies

Select item 20022361517.

Ribosome biogenesis controls suture mesenchymal stem cell fate via selective regulation ofcomplement pathway in to prevent craniosynostosis [Ribo-seq]

(Submitter supplied) Suture mesenchymal stem cell (MSC) drives calvarial suture development, homeostasis, and regeneration. Its loss leads to craniosynostosis, a prevailing craniofacial disorder characterized by premature suture closure. Ribosome biogenesis, historically thought to be a static house-keeping process, is now known to have tissue-specific roles. However, the functional specificity of ribosome biogenesis in suture MSCs remains largely unexplored, hampering development of therapeutic strategies for craniofacial tissue regeneration. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
4 Samples

Download data: TXT

Series

Accession:: GSE223615

ID:: 200223615

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022361418.

Ribosome biogenesis controls suture mesenchymal stem cell fate via selective regulation of complement pathway in to prevent craniosynostosis [RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
4 Samples

Download data: TXT

Series

Accession:: GSE223614

ID:: 200223614

PubMed Full text in PMC Similar studies

Select item 20015145219.

RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels

(Submitter supplied) The eukaryotic RNA exosome is a ubiquitously expressed complex of nine core proteins (EXOSC1-9) and associated nucleases responsible for RNA processing and degradation. Autosomal recessive mutations in EXOSC3, EXOSC8, EXOSC9 and the exosome cofactor RBM7 cause pontocerebellar hypoplasia and motor neuronopathy. To understand the importance of the exosome in neurodegeneration, we investigated the consequences of exosome mutations on RNA metabolism and cellular survival in zebrafish and human cell models. more...

Organism:: Danio rerio; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18413 GPL16791
108 Samples

Download data: TXT

Series

Accession:: GSE151452

ID:: 200151452

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013572220.

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

(Submitter supplied) In ribosomopathies, perturbed expression of ribosome components leads to tissue-specific phenotypes. What accounts for such tissue-selective manifestations as a result of mutations in the ribosome, a ubiquitous cellular machine, has remained a mystery. Combining mouse genetics and in vivo ribosome profiling, we observe limb patterning phenotypes in ribosomal protein (RP) haploinsufficient embryos and uncover selective translational changes of transcripts controlling limb development. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL19057
24 Samples

Download data: CSV

Series

Accession:: GSE135722

ID:: 200135722

PubMed Full text in PMC Similar studies SRA Run Selector

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