Similar studies for GEO DataSets (Select 200157322) - GEO DataSets

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Items: 12

Select item 2001573221.

Expression data from human osteoblast cultures

(Submitter supplied) Studies in Aotearoa New Zealand found higher bone mineral density and lower rate of hip fracture in people of Polynesian ancestry compared to Europeans. We hypothesised that differences in osteoblast gene expression contribute to the differences in bone properties between the two groups, and aimed to identify mechanisms that underlie the bone phenotype.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15207
20 Samples

Download data: CEL, CHP

Series

Accession:: GSE157322

ID:: 200157322

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000084062.

CTL-OA-OP human IT PF Bone - CompuGen H19K microarray study

(Submitter supplied) Aims of study: (1) To identify systemic differences in osteoarthritic (OA) bone that contribute to OA pathogenesis. (2) Identify novel osteoporotic (OP) bone-related disease genes. Study involved comparison of trabecular bone extracted from the intertrochanteric (IT) region of the proximal femur (PF) from OA, OP and normal/control (CTL) individuals. Bone was obtained from OA and OP individuals at surgery for total hip replacement and from CTL individuals at autopsy. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5391
39 Samples

Download data

Series

Accession:: GSE8406

ID:: 200008406

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001679183.

Loss of function of MALAT1 on primary human OA osteoblast transcriptome

(Submitter supplied) Cells: Primary human osteoblasts from subchondral bone of osteoarthritis patients (n=3 patients). Treatments: Cells transfected using Lipofectamine 3000 (Qiagen) with either control LNA (NC) or MALAT1 LNA1 or MALAT1 LNA2 for 24 hours. Total RNA extracted by Qiagen RNeasy columns. RIN values >7 via Agilent Bioanalyser. Analysis: RNA subjected to Quantseq 3' RNA sequencing (Lexogen) and sequenced reads mapped to the hg38 reference human genome.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
9 Samples

Download data: TXT

Series

Accession:: GSE167918

ID:: 200167918

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001073634.

Deduction of Novel Genes Potentially Involved in Osteoblasts of Rheumatoid Arthritis Using Next-Generation Sequencing and Bioinformatic Approaches

(Submitter supplied) The role of osteoblasts in peri-articular bone loss and bone erosion in rheumatoid arthritis (RA) has gained much attention, and microRNAs are hypothesized to play critical roles in the regulation of osteoblast function in RA. The aim of this study is to explore novel microRNAs differentially expressed in RA osteoblasts and to identify genes potentially involved in the dysregulated bone homeostasis in RA. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: XLS, XLSX

Series

Accession:: GSE107363

ID:: 200107363

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000092475.

Effect of histone deacetylase inhibitors on osteoblast gene expression

(Submitter supplied) Background: Osteoblast differentiation requires the coordinated stepwise expression of multiple genes. Histone deacetylase inhibitors (HDIs) accelerate the osteoblast differentiation process by blocking the activity of histone deacetylases (HDACs), which alter gene expression by modifying chromatin structure. We previously demonstrated that HDIs and HDAC3 shRNAs accelerate matrix mineralization and the expression of osteoblast maturation genes (e.g. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3002
Platform:: GPL1261
15 Samples

Download data: CEL

Series

Accession:: GSE9247

ID:: 200009247

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Select item 30026.

Histone deacetylase inhibitors effect on osteoblast differentiation

Analysis of MC3T3-E1 preosteoblasts treated with the histone deacetylase inhibitor (HDI) trichostatin A, MS-275, or valproic acid for 18 hours under osteogenic conditions. HDIs accelerate osteoblast maturation. Results provide insight into molecular mechanisms underlying osteoblast differentiation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 agent sets

Platform:: GPL1261
Series:: GSE9247
15 Samples

Download data: CEL

DataSet

Accession:: GDS3002

ID:: 3002

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001151977.

miRNA expression in BMSCs

(Submitter supplied) We performed microarray analysis to determine the expression profiles of miRNAs during osteoblast differentiation of BMSCs

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL25134
4 Samples

Download data: TXT

Series

Accession:: GSE115197

ID:: 200115197

Select item 2001151968.

circRNA expression in BMSCs

(Submitter supplied) We performed microarray analysis to determine the expression profiles of circRNAs during osteoblast differentiation of BMSCs

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL23467
4 Samples

Download data: TXT

Series

Accession:: GSE115196

ID:: 200115196

Select item 2000752329.

Genome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18573 GPL570
31 Samples

Download data: BEDGRAPH, CEL, CHP

Series

Accession:: GSE75232

ID:: 200075232

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007523110.

Genome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation (Dnase-Seq)

(Submitter supplied) DHS enahncers to identify novel pathways in OB differentiation

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
10 Samples

Download data: BEDGRAPH, CSV

Series

Accession:: GSE75231

ID:: 200075231

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007523011.

Genome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation (microarray)

(Submitter supplied) DHS enahncers identify novel pathways in OB differentiation

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
21 Samples

Download data: CEL, CHP

Series

Accession:: GSE75230

ID:: 200075230

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006039412.

Gene expression profiles of adult murine osteoblasts and cementoblasts

(Submitter supplied) Cementoblasts are cells that line the surface of the tooth root and produce a mineralized tissue known as cementum. Cementum is critical for attachment of the tooth to the adjacent periodontal ligament and has a similar biochemical composition to bone, however it differs in that it lacks vasculature and innervation, and does not undergo remodelling. It has been difficult to define markers that specifically identify cementoblasts. more...