Similar studies for GEO DataSets (Select 200162281) - GEO DataSets

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Items: 3

Select item 2001622811.

Segment-specific kinetics of mRNA, cRNA and vRNA during influenza infection

(Submitter supplied) Influenza A virus (IAV) is a segmented negative-sense RNA virus and is the cause of major global epidemics and pandemics. The replication of IAV is complex, involving both transcription and replication, during which three distinct RNA species, namely mRNA, cRNA, and vRNA are generated for all eight genome segments. While understanding IAV replication kinetics is important for drug development and improving vaccine production, current methods for studying IAV kinetics has been limited by the ability to detect all three different RNA species in a scalable manner. more...

Organism:: Canis lupus familiaris; Homo sapiens; Influenza A virus (A/Puerto Rico/8/1934(H1N1))

Type:: Expression profiling by high throughput sequencing

6 related Platforms
61 Samples

Download data: XLSX

Series

Accession:: GSE162281

ID:: 200162281

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001407592.

Viral determinants in H5N1 influenza A virus enable productive infection of HeLa cells

(Submitter supplied) Influenza A virus (IAV) is a human respiratory pathogen that causes yearly global epidemics, and sporadic pandemics due to human adaptation of pathogenic strains. Efficient replication of IAV in different species is, in part, dictated by its ability to exploit the genetic environment of the host cell. To investigate IAV tropism in human cells, we evaluated the replication of IAV strains in a diverse subset of epithelial cell lines. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
8 Samples

Download data: TXT

Series

Accession:: GSE140759

ID:: 200140759

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001222863.

In vivo analysis of Influenza A mRNA secondary structures identifies critical regulatory motifs

(Submitter supplied) The Influenza A virus (IAV) is a continuous health threat to humans as well as animals due to its high mutational rate and recurring epidemics and pandemics. The IAV genome is segmented and the eight negative-sense viral RNAs (vRNAs) are transcribed into positive sense RNAs (cRNAs) and viral messenger RNAs (vmRNAs) inside infected host cells. A role for the secondary structure of vmRNAs has been hypothesized and debated for many years, but knowledge on the structure vmRNAs adopt in vivo is currently missing. more...