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Links from GEO DataSets

Items: 20

1.

The Cryptococcal Central Nervous System Transcriptome during Human Disease

(Submitter supplied) The transcriptional responses of cryptococcus during human infection are dynamic and highly dependent on the immediate signals from the environment. We examined the RNA-Seq profiles of Cryptococcus isoalted from human CSF and in comparison with to the same isolate's response to the stresses of artificial CSF and within the rabbit subarachnoid space as well as growth in nutritious media with little or no stress. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19081 GPL27451
125 Samples
Download data: TXT
Series
Accession:
GSE171092
ID:
200171092
2.

The Cryptococcus transcriptome at the site of human meningitis

(Submitter supplied) Cryptococcus neoformans is a major cause of fungal meningitis in immunocompromised individuals worldwide. Studies have categorized the transcriptome of Cryptococcus under various stresses, such as temperature, nitric oxide, iron, antifungal drugs and macrophages. However, an accurate and comprehensive transcriptome profiling of C. neoformans in the human host may allow an even better understanding of its survival and disease production. more...
Organism:
Cryptococcus neoformans var. grubii
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17123 GPL17822
6 Samples
Download data: XLS
Series
Accession:
GSE51573
ID:
200051573
3.

Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses

(Submitter supplied) Cryptococcus neoformans is an opportunistic environmental fungal pathogen that at its peak epidemic levels caused an estimated million cases of cryptococcal meningitis per year worldwide. This yeast can adapt to various external (trees, soil, and/or bird excreta) and internal environments (intracellular microenvironments of phagocytes and/or free-living in host tissues/fluids). The genetic basic for this adaptation is not fully characterized and primarily relies on a single reference C. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14571
118 Samples
Download data: TXT
Series
Accession:
GSE136879
ID:
200136879
4.

The transcription factor Pdr802 regulates Titan cell production and Cryptococcus neoformans pathogenicity (RNA-Seq)

(Submitter supplied) We report on our study the role of C. neoformans transcription factor Pdr802, whose expression is highly induced under host-like conditions in vitro and is critical for C. neoformans dissemination and virulence in a mouse model of infection. We found that direct targets of Pdr802 include the calcineurin targets Had1 and Pmc1, which are important for C. neoformans virulence, the transcription factor Bzp4, which promotes cryptococcal melanization and capsule thickness, and 35 transmembrane transporters. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27451
56 Samples
Download data: CSV
Series
Accession:
GSE162851
ID:
200162851
5.

The transcription factor Pdr802 regulates Titan cell production and Cryptococcus neoformans pathogenicity

(Submitter supplied) We report on our study the role of C. neoformans transcription factor Pdr802, whose expression is highly induced under host-like conditions in vitro and is critical for C. neoformans dissemination and virulence in a mouse model of infection. We found that direct targets of Pdr802 include the calcineurin targets Had1 and Pmc1, which are important for C. neoformans virulence, the transcription factor Bzp4, which promotes cryptococcal melanization and capsule thickness, and 35 transmembrane transporters. more...
Organism:
Cryptococcus neoformans
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL27451
12 Samples
Download data: BED, NARROWPEAK
Series
Accession:
GSE153134
ID:
200153134
6.

Cdk8 and Ssn801 regulate oxidative stress resistance and virulence in Cryptococcus neoformans

(Submitter supplied) Cryptococcus neoformans is an important pathogen that annually kills 200,000 people worldwide. It survives in the environment as a yeast or spore and can also proliferate within host macrophages after being inhaled into the lungs. In conditions of immunocompromise, cryptococcal cells can escape from the lungs to the brain, where they cause a deadly meningoencephalitis that is both difficult and expensive to treat. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19081
21 Samples
Download data: TSV
Series
Accession:
GSE125281
ID:
200125281
7.

QTL Mapping and Bulk Segregant Analysis identifies CO2 tolerance genes associated with virulence in the global pathogen Cryptococcus neoformans

(Submitter supplied) Cryptococcus neoformans is a ubiquitous free-living soil yeast and opportunistic pathogen that causes ~223,100 cases of cryptococcal meningitis per year, killing over 180,000 people. The pathogenicity of C. neoformans relies on its adaptation to the host conditions. An important difference between its natural environment and the mammalian host is the concentration of CO2. CO2 levels in the host fluctuate around 5%, which is ~125-fold higher than in ambient air. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21073
18 Samples
Download data: XLSX
Series
Accession:
GSE260932
ID:
200260932
8.

Functional dissection of the regulatory mechanism of the atypical AP-1-like transcription factor, Yap1, in Cryptococcus neoformans

(Submitter supplied) AP-1 like transcription factors play evolutionarily conserved roles in oxidative stress responses as redox sensors in eukaryotes. In this study, we aim to elucidate the regulatory mechanism of an atypical yeast AP-1 like protein, Yap1, in the stress response and virulence of Cryptococcus neoformans. YAP1 expression was induced not only by oxidative stresses, such as H2O2 and diamide, but also by other environmental stresses, such as osmotic and membrane destabilizing stresses. more...
Organism:
Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23176
6 Samples
Download data: XLSX
Series
Accession:
GSE136832
ID:
200136832
9.

Usv101 is a key regulator of cryptococcal virulence and determinant of host response

(Submitter supplied) Cryptococcus neoformans is a fungal pathogen responsible for hundreds of thousands of deaths per year. Its critical virulence factor is a polysacharride capsule which grows large upon entry into a mammalian host. We previously identified USV101 as a transcription factor whose deletion results in enlarged capsules. Here, we characterize strains lacking or overexpressing USV101 in terms of their virulence-related phenotypes, the altered course of infection by them and immune response to them in a mouse model, the relationship of Usv101 to other transcription factors involved in capsule regulation, and the changes in Usv101 activity during capsule induction.
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19081
46 Samples
Download data: CUFF, TXT
Series
Accession:
GSE69532
ID:
200069532
10.

Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation

(Submitter supplied) Purpose: Key steps in understanding a biological process include identifying genes that are involved and determining how they are regulated. We developed a novel method for identifying TFs involved in a specific process and used it to map regulation of the key virulence factor of Cryptococcus neoformans, its capsule. Results: The map, built from expression profiles of 41 TF mutants, includes 20 TFs not previously known to regulate virulence attributes. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19081 GPL14571
320 Samples
Download data: BED, CUFF, TXT
Series
Accession:
GSE60398
ID:
200060398
11.

The transcriptional response of Cryptococcus neoformans to ingestion by Acanthamoeba castellanii and murine macrophages

(Submitter supplied) Virulence of Cryptococcus neoformans for mammals was proposed to emerge from evolutionary pressures on its natural environment by protozoan predators, which selected for strategies that allow survival within macrophages. In fact, Acanthamoeba castellanii ingests yeast cells, which then replicate intracellularly. In addition, most fungal factors needed to establish infection in the mammalian host are also important for survival within the amoeba. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by array
Platform:
GPL15151
12 Samples
Download data: GPR
Series
Accession:
GSE45027
ID:
200045027
12.

Unveil the transcriptional landscape at the Cryptococcus-host axis in mice and nonhuman primates

(Submitter supplied) Pathogens and hosts require rapid modulation of virulence and defense mechanisms at the infection axis, but monitoring such modulations is challenging. In studying the human fungal pathogen Cryptococcus neoformans, mouse and rabbit infection models are often employed to shed light on the disease mechanisms but that may not be clinically relevant. In this study, we developed an animal infection model using the non-human primate cynomolgus monkey Macaca fascicularis. more...
Organism:
Macaca fascicularis; Cryptococcus neoformans var. grubii H99; Mus musculus
Type:
Expression profiling by high throughput sequencing
5 related Platforms
21 Samples
Download data: TXT
Series
Accession:
GSE122785
ID:
200122785
13.

Identification and characterization of HVA1 (CNAG_02591) in Cryptococcus neoformans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Cryptococcus neoformans; Cryptococcus neoformans var. neoformans
Type:
Expression profiling by array
Platforms:
GPL4009 GPL15151
20 Samples
Download data: CSV, GPR
Series
Accession:
GSE59583
ID:
200059583
14.

Comparison of the wild-type strain H99W with the hva1∆, hva1∆+HVA1 and a Galleria-passaged strain

(Submitter supplied) Changes in gene expression of the serotype A wild-type strain H99W with the hva1∆ (8), hva1∆+HVA1 (8-15) or a Galleria-passaged (P15) strain were examined during log-phase growth at 37 ºC.
Organism:
Cryptococcus neoformans
Type:
Expression profiling by array
Platform:
GPL15151
12 Samples
Download data: CSV, GPR, TXT
Series
Accession:
GSE59582
ID:
200059582
15.

Comparison of the pre-passage wild-type strain H99W with two mouse-passaged strains

(Submitter supplied) Changes in gene expression of the serotype A pre-passage wild-type strain H99W with two mouse-passaged strains were examined during log-phase growth at 37 ºC.
Organism:
Cryptococcus neoformans; Cryptococcus neoformans var. neoformans
Type:
Expression profiling by array
Platform:
GPL4009
8 Samples
Download data: CSV, TXT
Series
Accession:
GSE59581
ID:
200059581
16.

Comparative transcriptome analysis of the CO2 sensing pathway via differential expressions of carbonic anhydrase in Cryptococcus neoformans

(Submitter supplied) Carbon dioxide (CO2) sensing, transport, and metabolism play a pivotal role in survival and proliferation of pathogenic microbes infecting human host from natural environments due to the drastic difference of CO2 levels. Carbonic anhydrases (CAs) are not only key CO2-metabolic enzymes catalyzing reversible interconversion between CO2 and bicarbonate (HCO3-), but also important CO2-signaling modulators. more...
Organism:
Cryptococcus neoformans var. neoformans JEC21; Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by array
Platform:
GPL8638
17 Samples
Download data: GPR
Series
Accession:
GSE21192
ID:
200021192
17.

ChIP-Seq and RNA-Seq analysis of the iron regulatory transcription factors in Cryptococcus neoformans in response to iron availability

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21548 GPL23176
26 Samples
Download data
Series
Accession:
GSE126314
ID:
200126314
18.

Transcriptome analysis of the iron regulatory transcription factors in Cryptococcus neoformans in response to iron availability

(Submitter supplied) Purpose: Understanding the iron-responsive regulatory networks in Cryptococcus neoformans. Methods: The transcriptome profiles of the wild-type, cir1 mutant and hapX mutant were generated by RNA-seq using Illumina Hiseq, in triplicate. The transcriptome profiles of each mutant was compared with that of the wild-type strain. Results: The iron-responsive transcription factors, Cir1 and HapX, are major regulators for iron acquisition and metabolism in C. more...
Organism:
Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21548
18 Samples
Download data: XLSX
Series
Accession:
GSE126313
ID:
200126313
19.

ChIP-Seq analysis of the iron regulatory transcription factors in Cryptococcus neoformans in response to iron availability

(Submitter supplied) Purpose: Defining the regulatory role of the transcription factors, Cir1 and HapX, in C. neoformans. Methods: Chromatin immunoprecipitation followed by high-throughput sequencing was performed using chromatin immunoprecipitated DNA from the strains Cir1-Flag and HapX-Flag grown in low- and high-iron condition. Results: Cir1 and HapX bind to the promoter region of the genes involved in iron acquisition and metabolism in C. more...
Organism:
Cryptococcus neoformans var. grubii H99
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL23176
8 Samples
Download data: XLSX
Series
Accession:
GSE126312
ID:
200126312
20.

Pleiotropic roles of LAMMER kinase, Lkh1 in stress responses and virulence of Cryptococcus neoformans

(Submitter supplied) To investigate the pleiotropic roles of Lkh1 in stress response and virulence, we constructed lkh1∆ mutant strains. In this study, we found that Tor1 was an upstream regulator of Lkh1 in C. neoformans. We then performed gene expression profiling analysis to elucidate signaling circuitry downstream of CnLkh1 in the TOR1-Lkh1 pathway using data obtained from RNA seq of 2 different strains (WT of lkh1∆ mutant) with or without rapamycin treatment.
Organism:
Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33437
12 Samples
Download data: TXT
Series
Accession:
GSE233612
ID:
200233612
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