Similar studies for GEO DataSets (Select 200171252) - GEO DataSets

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Items: 20

Select item 2001712521.

Single-cell RNA-seq in pancreatic islets of Tg7 mice

(Submitter supplied) Objective: beta-cell dedifferentiation has been revealed as a pathological mechanism underlying pancreatic dysfunction in diabetes. However, exactly how such dedifferentiation process affects beta-cell gene expression and islet microenvironment remains incompletely understood Method: We performed single-cell RNA-Sequencing (RNA-seq) in islets obtained from beta-cell-specific miR-7a2 overexpressing mice (Tg7), a murine model of beta-cell dedifferentiation and diabetes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE171252

ID:: 200171252

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Select item 2001712542.

Dysregulation of a Pdx1/Ovol2/Zeb2 axis in dedifferentiated beta-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
14 Samples

Download data: MTX, TSV

Series

Accession:: GSE171254

ID:: 200171254

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Select item 2001712513.

Bulk RNA-seq in pancreatic islets of Tg7 mice

(Submitter supplied) Objective: beta-cell dedifferentiation has been revealed as a pathological mechanism underlying pancreatic dysfunction in diabetes. However, exactly how such dedifferentiation process affects beta-cell gene expression and islet microenvironment remains incompletely understood Method: We performed bulk in islets obtained from beta-cell-specific miR-7a2 overexpressing mice (Tg7), a murine model of beta-cell dedifferentiation and diabetes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: CSV

Series

Accession:: GSE171251

ID:: 200171251

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Select item 2001069504.

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16686 GPL18460
12 Samples

Download data: CEL

Series

Accession:: GSE106950

ID:: 200106950

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Select item 2001069495.

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors [ChIP-seq]

(Submitter supplied) We performed ChIP-seq of PDX1 and H3K27ac on XM001 cells at PP stage

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18460
8 Samples

Download data: BED

Series

Accession:: GSE106949

ID:: 200106949

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Select item 2001068136.

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors [expression profiling]

(Submitter supplied) Objective: Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous mutations can cause Maturity-Onset Diabetes of the Young 4 (MODY4). Although the function of Pdx1 is well studied in pre-clinical models during insulin-producing β-cell development and homeostasis, it remains elusive how this TF controls human pancreas development by regulating a downstream transcriptional program. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
4 Samples

Download data: CEL

Series

Accession:: GSE106813

ID:: 200106813

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Select item 2000560897.

Expression profiling of EpH4 mouse mammary epithelial cells overexpressing the AP-1 transcription factor component Fra1

(Submitter supplied) RNA of control mouse mammary epithelial cells (EpH4 control) and corresponding fra1 overexpressing cells (EpH4fra1 cl1 and EpH4fra1 cl2) was hybridized onto an 53MM chip and differentially expressed targets were further analysed. For each sample hybridization was performed in technical triplicate

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL18447
3 Samples

Download data: GPR

Series

Accession:: GSE56089

ID:: 200056089

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Select item 2001165328.

ZEB2, a master regulator of the epithelial-mesenchymal transition, mediates trophoblast differentiation

(Submitter supplied) Comparison of genes associated with the EMT between trophoblast cell line (BeWo, JEG3) controls and cells overexpressing the ZEB2 gene (BeWo ZEB2oe, JEG_ZEB2oe).

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL20702
18 Samples

Download data: TXT

Series

Accession:: GSE116532

ID:: 200116532

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Select item 2000847599.

LIM-Domain-Binding 1 maintains the terminally-differentiated state of pancreatic β-cells

(Submitter supplied) Utilize high-throughput transcriptomic and cistromic analysis to determine the functional requirement for LDB1 and ISL1 in mature murine pancreatic β-cells while simultaneously assessing their functional interdependence at the chromatin level.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
21 Samples

Download data: BED, BW, XLSX

Series

Accession:: GSE84759

ID:: 200084759

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Select item 20002201010.

TMPRSS2:ERG promotes invasiveness and epithelial to mesenchymal transition in prostate cancer model

(Submitter supplied) Recently, a frequent chromosomal aberration fusing Androgen regulated TMPRSS2 promoter and the ERG gene (T/ERG) was discovered in prostate cancer. Several studies demonstrated cooperation between the T/ERG and other defective pathways in cancer progression however, the biological mechanism by which the T/ERG operates is yet to be determined. Using immortalized prostate epithelial cells (EP) model we were able to show that EP with the combination of androgen receptor(AR) and T/ERG(EP-AR T/ERG cell line) demonstrate an Epithelial to Mesenchymal Transition (EMT) manifested by a mesenchyme-like morphological appearance and behavior. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE22010

ID:: 200022010

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Select item 20004209511.

Dynamic regulation of miRNA and mRNA signatures during in vitro pancreatic differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL8179 GPL10558
46 Samples

Download data

Series

Accession:: GSE42095

ID:: 200042095

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Select item 20004209412.

Dynamic regulation of miRNA and mRNA signatures during in vitro pancreatic differentiation (mRNA)

(Submitter supplied) The remarkable differentiation capacity of pluripotent stem cells into any adult cell types have enabled researchers to model human embryonic development and disease process in dishes, as well as deriving specialized cells for replacing damaged tissues. Type 1 diabetes is a degenerative disease characterized by autoimmune destruction of the insulin-producing beta islet cells in the pancreas. Recent advances have led to the establishment of different methods to direct differentiation of human or mouse pluripotent stem cells toward beta cell lineages. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
23 Samples

Download data: TXT

Series

Accession:: GSE42094

ID:: 200042094

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Select item 20004209313.

Dynamic regulation of miRNA and mRNA signatures during in vitro pancreatic differentiation (miRNA)

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL8179
23 Samples

Download data: TXT

Series

Accession:: GSE42093

ID:: 200042093

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Select item 20011523914.

RNA-seq following JunD depletion

(Submitter supplied) RNA-seq performed in Min6 cells during glucolipotoxicity after CRISPR-mediated depletion of JunD

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE115239

ID:: 200115239

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Select item 20011521915.

TRAP-seq following Pdx1 depletion

(Submitter supplied) TRAP performed in GFP-RPL10A Min6 cells transfected with siRNA targeting Pdx1 or a non-targeting (NT) control. IP RNA was isolated by TRAP protocol and input lysate was used to isolate Total RNA. RNA-seq was performed on both IP and Total RNA.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
12 Samples

Download data: TXT

Series

Accession:: GSE115219

ID:: 200115219

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Select item 20024099316.

Dynamic regulation of pancreatic β cell function and gene expression by the SND1 coregulator in vitro

(Submitter supplied) The pancreatic β cell synthesizes, packages, and secretes insulin in response to glucose-stimulation to maintain blood glucose homeostasis. Under diabetic conditions, a subset of β cells fail and lose expression of key transcription factors (TFs) required for insulin secretion. Among these TFs is Pancreatic and duodenal homeobox 1 (Pdx1), which recruits a unique subset of transcriptional coregulators to modulate its activity. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: TAB, XLSX

Series

Accession:: GSE240993

ID:: 200240993

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Select item 20003845917.

miRNA profiles in head and neck natural epithelial - mesenchymal phenotype cell line pair, and in TGF-β induced EMT models

(Submitter supplied) Sixth generation Exiqon® locked nucleic acid miRCURY™ LNA microarrays were used to search and validate some unidentified miRNAs that regulate EMT in head and neck cancer carcinoma.

Organism:: Homo sapiens; Murid gammaherpesvirus 4; Betapolyomavirus hominis; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Mus musculus cytomegalovirus 2; Betapolyomavirus macacae; Rattus norvegicus; Human alphaherpesvirus 2; Merkel cell polyomavirus; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1

Type:: Non-coding RNA profiling by array

Platform:: GPL11434
3 Samples

Download data: TXT

Series

Accession:: GSE38459

ID:: 200038459

Select item 20010304818.

Identification of ZEB2 binding sites in Hepatocellular Carcinoma Cell Line SNU398

(Submitter supplied) ZEB2, a member of the ZEB family of EMT inducers, is involved in cellular proliferation, senescence, and invasion in most of the human cancers. However, genes regulated by ZEB2 in hepatocellular carcinoma (HCC) are not identified so far. Hence, we conducted a ChIP-Seq study in high ZEB2 expressing HCC cell line SNU398 by using a homemade anti-ZEB2 antibody (clone 6E5).

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
2 Samples

Download data: BW

Series

Accession:: GSE103048

ID:: 200103048

PubMed Similar studies SRA Run Selector

Select item 20002742419.

NOTCH3 knockdown in non-transformed human esophageal cells

(Submitter supplied) To determine the role of NOTCH3 in human esophageal epitheila homeostasis/squamous cell differentiation Zinc finger E-box binding (ZEB) proteins ZEB1 and ZEB2 are transcription factors essential in transforming growth factor (TGF)-β-mediated epithelial to mesenchymal transition (EMT), senescence and cancer stem cell maintenance through mutual negative regulation of the microRNA (miR)-200 family members. more...