Similar studies for GEO DataSets (Select 200179039) - GEO DataSets

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Items: 20

Select item 2001790391.

Epigenetic aging of the demographically non-aging naked mole-rat [RRBS]

(Submitter supplied) The naked mole-rat (NMR) is an exceptionally long-lived rodent that does not show increased mortality with age, uniquely defining NMR as a demographically non-aging mammal. Here, we performed bisulfite sequencing on over one hundred NMR blood samples differing in age, assessing more than 3 million common CpG sites. We observed an information loss of the NMR methylome during aging suggesting that NMR ages. more...

Organism:: Heterocephalus glaber

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL21195
107 Samples

Download data: COV

Series

Accession:: GSE179039

ID:: 200179039

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Select item 2001379572.

DNA methylation clocks as a predictor for ageing and age estimation in naked mole-rats, Heterocephalus glaber

(Submitter supplied) The naked mole-rat, Heterocephalus glaber (NMR), the longest-lived rodent with a maximum possible lifespan exceeding 33 years, is emerging as an important non-model organism for the study of longevity and healthspan. As such it is of significance and interest in the study of biomarkers for ageing in mammals. Recent breakthroughs in this field have indicated that ‘epigenetic clocks’ based on the temporal accumulation of DNA methylation at specific genomic sites can enable accurate age estimates for tissues across the lifespan of an individual. more...

Organism:: Heterocephalus glaber

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL27526
39 Samples

Download data: CSV

Series

Accession:: GSE137957

ID:: 200137957

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Select item 2001042173.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Macaque_450k]

(Submitter supplied) We used blood samples from Macaque to determine rate of change of methylation with respect to age.

Organism:: Homo sapiens; Macaca mulatta

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
6 Samples

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Series

Accession:: GSE104217

ID:: 200104217

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Select item 2001042164.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [TC1_450k]

(Submitter supplied) We used liver samples from TC1 Mice to determine rate of change of methylation with respect to age.

Organism:: Homo sapiens; Mus musculus

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
6 Samples

Download data: TXT

Series

Accession:: GSE104216

ID:: 200104216

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Select item 2001042155.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: naked mole-rat]

(Submitter supplied) We used liver samples from Naked Mole Rat to determine rate of change of methylation with respect to age.

Organism:: Heterocephalus glaber

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL24046
24 Samples

Download data: TXT

Series

Accession:: GSE104215

ID:: 200104215

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Select item 2000860596.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Macaca mulatta; Mus musculus; Heterocephalus glaber; Homo sapiens; Canis lupus familiaris

Type:: Methylation profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:: GPL24046 GPL13534 GPL22370
84 Samples

Download data: TXT

Series

Accession:: GSE86059

ID:: 200086059

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Select item 2000860587.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: dog]

(Submitter supplied) We used buccal samples from two different dog breeds with well established differences in average lifespan to perform genome-scale identification of ageing-associated differentially methylated positions (aDMPs) in a total of 48 different dogs. A significant proportion of aDMPs that gained methylation with age replicated in an independent cohort. Furthermore, we also show that human aDMPs show similar ageing-associated dynamics at the homologous genomic regions in the dog. more...

Organism:: Canis lupus familiaris

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL22370
48 Samples

Download data: TXT

Series

Accession:: GSE86058

ID:: 200086058

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Select item 2000987198.

RNA-seq of breeding and non-breeding naked mole-rats and guinea pigs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Heterocephalus glaber; Cavia porcellus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL22346 GPL21195
476 Samples

Download data

Series

Accession:: GSE98719

ID:: 200098719

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Select item 2000986679.

RNA-seq of naked mole-rat liver from breeders and non-breeders [livers]

(Submitter supplied) Comparison of gene expression level by Illumina sequencing of naked mole-rat liver from breeders and non-breeders.

Organism:: Heterocephalus glaber

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21195
23 Samples

Download data: XLS

Series

Accession:: GSE98667

ID:: 200098667

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Select item 20009866310.

RNA-seq of nine naked mole-rat tissues from breeders and non-breeders

(Submitter supplied) Comparison of gene expression level by Illumina sequencing of nine different naked mole-rat tissue from breeders and non-breeders.

Organism:: Heterocephalus glaber

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21195
215 Samples

Download data: XLS

Series

Accession:: GSE98663

ID:: 200098663

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Select item 20009865311.

RNA-seq of ten guinea pig tissues from breeders and non-breeders

(Submitter supplied) Comparison of gene expression level by Illumina sequencing of ten different guinea pig tissue from breeders and non-breeders.

Organism:: Cavia porcellus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22346
238 Samples

Download data: XLS

Series

Accession:: GSE98653

ID:: 200098653

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Select item 20003033712.

Transcriptome sequencing of naked mole rat, Heterocephalus glaber

(Submitter supplied) Deep sequencing of mRNA from naked mole rat

Organism:: Heterocephalus glaber

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13793
13 Samples

Download data: BEDGRAPH

Series

Accession:: GSE30337

ID:: 200030337

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Select item 20006299213.

Predicting genome-wide DNA methylation

(Submitter supplied) Genome wide DNA methylation profiling of normal whole blood samples. The data consist of 100 samples with Illumina HumanMethylation450 BeadChip data.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
100 Samples

Download data: TXT

Series

Accession:: GSE62992

ID:: 200062992

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Select item 20005610514.

Brisbane Systems Genetics Study – DNA methylation data

(Submitter supplied) DNA methylation data on 614 individuals from 117 families consisting of combinations of MZ and DZ twin pairs, their siblings and their parents.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
614 Samples

Download data: TXT

Series

Accession:: GSE56105

ID:: 200056105

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Select item 20016114115.

A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin-associated histone modifications

(Submitter supplied) Aging has been shown to be a strong driver of DNA methylation changes, leading to the development of robust biomarkers in humans and more recently, in mice. This study aimed to generate a novel epigenetic clock in rats—a model with unique physical, physiological, and biochemical advantages for studying mammalian aging. Additionally, we incorporated behavioral data, unsupervised machine learning, and network analysis to identify epigenetic signals that not only track with age, but also relate to phenotypic aging and reflect higher-order molecular aging changes. more...

Organism:: Rattus norvegicus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL18694
134 Samples

Download data: CGMAP

Series

Accession:: GSE161141

ID:: 200161141

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Select item 20012013716.

A multi-tissue full lifespan epigenetic clock for mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing; Third-party reanalysis

Platforms:: GPL17021 GPL21103
549 Samples

Download data: CSV, TXT

Series

Accession:: GSE120137

ID:: 200120137

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Select item 20012013617.

A multi-tissue full lifespan epigenetic clock for mice [II]

(Submitter supplied) Human DNA-methylation data have been used to develop highly accurate biomarkers of aging ("epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for mice (Mus Musculus) can be slowed by gold standard anti-aging interventions such as calorie restriction and growth hormone receptor knock-outs. Using DNA methylation data from previous publications with data collected in house for a total 1189 samples spanning 193,651 CpG sites, we developed 4 novel epigenetic clocks by choosing different regression models (elastic net- versus ridge regression) and by considering different sets of CpGs (all CpGs vs highly conserved CpGs). more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing; Third-party reanalysis

Download data: TXT

Series

Accession:: GSE120136

ID:: 200120136

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Select item 20012013218.

A multi-tissue full lifespan epigenetic clock for mice [I]

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platforms:: GPL21103 GPL17021
549 Samples

Download data: TXT

Series

Accession:: GSE120132

ID:: 200120132

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Select item 20013128019.

DNA Methylation of primary human fibroblasts across replicative lifespan in normal and hyperglycemic conditions

(Submitter supplied) Genome wide DNA methylation profiling of normal (5.5mM) and high (25mM) glucose samples from primary human fibroblasts across the cellular lifespan. The Illumina Infinium EPIC Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 866,836 CpGs. Samples included 12 normal glucose time points and 14 high glucose time points, as well as, 6 technical replicates of normal glucose timepoint at 34.8 days. more...