Similar studies for GEO DataSets (Select 200182875) - GEO DataSets

Select item 2001828751.

Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients

(Submitter supplied) From Stertz et al 2021 "Human-induced pluripotent stem cells (hiPSCs) allow for the establishment of brain cellular models of psychiatric disorders that account for a patient’s genetic background. Here, we conducted an RNA-sequencing profiling study of hiPSC-derived cell lines from schizophrenia (SCZ) subjects, most of which are from a multiplex family, from the population isolate of the Central Valley of Costa Rica. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
32 Samples

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Series

Accession:: GSE182875

ID:: 200182875

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001504292.

Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan McDermid syndrome and autism

(Submitter supplied) We developed human induced pluripotent stem cell (hiPSC)-based models of PMS by reprogramming peripheral blood samples from individuals with PMS (n=7) and their unaffected siblings (n=6).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
80 Samples

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Series

Accession:: GSE150429

ID:: 200150429

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000255203.

PI3K/mTOR specific phospho-antibody microarray to study the effect of rapamycin to the innate immune respsonse

(Submitter supplied) To comprehensively analyze the effects of mTORC1 inhibition on GSK3, we employed the use of a PI3K/mTOR-specific phospho-antibody microarray that analyzed the site-specific phosphorylation of over 130 kinases within the PI3K/mTOR pathway. The phosphorylation levels of different kinases in monocytes were measured when stimulated with LPS in the presence or absence of a kind of mTORC1 inhibitor, rapamycin

Organism:: Homo sapiens

Type:: Protein profiling by protein array

Platform:: GPL11222
2 Samples

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Series

Accession:: GSE25520

ID:: 200025520

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Select item 2000465624.

RNA-seq in neurons derived from iPSCs in controls and patients with schizophrenia and 22q11 del

(Submitter supplied) Individuals with 22q11.2 Deletion Syndrome (22q11.2 DS) are a specific high-risk group for developing schizophrenia (SZ), schizoaffective disorder (SAD) and autism spectrum disorders (ASD). Several genes in the deleted region have been implicated in the development of SZ, e.g., PRODH and DGCR8. However, the mechanistic connection between these genes and the neuropsychiatric phenotype remains unclear. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
19 Samples

Download data: TXT

Series

Accession:: GSE46562

ID:: 200046562

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2002151835.

Excitatory dysfunction drives network and calcium handling deficits in 16p11.2 duplication schizophrenia iPSC-derived neurons

(Submitter supplied) Background - Schizophrenia (SCZ) is a debilitating psychiatric disorder with a large genetic contribution; however, its neurodevelopmental substrates remain largely unknown. Modeling pathogenic processes in SCZ using human iPSC-derived neurons (iNs) has emerged as a promising strategy. Copy number variations (CNV) confer high genetic risk for SCZ, with duplication of the 16p11.2 locus increasing risk 14.5 fold. more...