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Links from GEO DataSets

Items: 11

1.

Gene expression (GeneChip) data from scramble- and CRMP2A siRNA-treated A549 cells.

(Submitter supplied) We sought to assess how temporary loss of the microtubule-associated protein CRMP2A could affect global gene expression in the A549 lung cancer cells. We used microarrays to identify differentially regulated genes when CRMP2A is temporarily removed from A549 cells using siRNA.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15207
2 Samples
Download data: CEL
Series
Accession:
GSE196499
ID:
200196499
2.

Gene expression (GeneChip) data from parental (wild-type) and CRMP2A KO (CRISPR) A549 cells.

(Submitter supplied) We sought to assess how permanent loss of the microtubule-associated protein CRMP2A could affect global gene expression in the A549 lung cancer cells. We used microarrays to identify differentially regulated genes when CRMP2A is permanently removed from A549 cells using CRISPR/Cas9.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15207
2 Samples
Download data: CEL
Series
Accession:
GSE196494
ID:
200196494
3.

Gene expression of SUM159 breast cancer cell line expressing microRNA--203

(Submitter supplied) Determine the effect of miR-203 expression on the global mRNA expression in mesenchymal breast cancer cell line.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5348
Platform:
GPL570
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE50697
ID:
200050697
4.
Full record GDS5348

miR-203 overexpression effect on mesenchymal-like breast cancer cell line

Analysis of SUM159 mesenchymal-like breast cancer cells overexpressing miR-203. Result provide insight into the role of miR-203 in epithelial-mesenchymal transition and metastasis in breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL570
Series:
GSE50697
6 Samples
Download data: CEL, CHP
5.

TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis

(Submitter supplied) Using a TWIST1-inducible epithelial-to-mesenchymal transition (EMT) model in HMLE cells, miRNA changes were profiled at different time points during an active EMT.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL18795
12 Samples
Download data: TXT
Series
Accession:
GSE58560
ID:
200058560
6.

TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis

(Submitter supplied) Epithelial-to-mesenchymal transition (EMT) is a dynamic process that relies on cellular plasticity; an EMT/MET axis is critical for metastatic colonization of carcinomas. Unlike epithelial programming, regulation of mesenchymal programming is not well understood in EMT. Here we describe the first microRNA that enhances exclusively mesenchymal programming. We demonstrate that microRNA-424 is up-regulated early during a TWIST1/SNAI1-induced EMT, and that it causes cells to express mesenchymal genes without affecting epithelial genes, resulting in a mixed/intermediate EMT. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: TXT
7.

HDAC inhibition impedes epithelial–mesenchymal plasticity and suppresses metastatic, castration-resistant prostate cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL10361 GPL13112
17 Samples
Download data: TXT
Series
Accession:
GSE67879
ID:
200067879
8.

HDAC inhibition impedes epithelial–mesenchymal plasticity and suppresses metastatic, castration-resistant prostate cancer

(Submitter supplied) PI3K (phosphoinositide 3-kinase)/AKT and RAS/MAPK (mitogen-activated protein kinase) pathway coactivation in the prostate epithelium promotes both epithelial–mesenchymal transition (EMT) and metastatic castration-resistant prostate cancer (mCRPC), which is currently incurable. To study the dynamic regulation of the EMT process, we developed novel genetically defined cellular and in vivo model systems from which epithelial, EMT and mesenchymal-like tumor cells with Pten deletion and Kras activation can be isolated. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10361
11 Samples
Download data: TXT
Series
Accession:
GSE67872
ID:
200067872
9.

HDAC inhibition impedes epithelial–mesenchymal plasticity and suppresses metastatic, castration-resistant prostate cancer

(Submitter supplied) PI3K (phosphoinositide 3-kinase)/AKT and RAS/MAPK (mitogen-activated protein kinase) pathway coactivation in the prostate epithelium promotes both epithelial–mesenchymal transition (EMT) and metastatic castration-resistant prostate cancer (mCRPC), which is currently incurable. To study the dynamic regulation of the EMT process, we developed novel genetically defined cellular and in vivo model systems from which epithelial, EMT and mesenchymal-like tumor cells with Pten deletion and Kras activation can be isolated. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: TXT
Series
Accession:
GSE67681
ID:
200067681
10.

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(Submitter supplied) In this study we studied the presence of tumor cells that underwent epithelial-to-mesenchymal transition within polyoma middle T antigen (PyMT) breast tumors. For this we dissociated tumors and isolated Ecad positive tumor cells by FACS sorting. We confirmed that PyMT tumors contain a small set of tumor cells that have undergone EMT in the primary tumor and that E-cadherin can be used as a marker on single cell level for mesenchymal status in this model.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL19057
7 Samples
Download data: CSV, TXT
Series
Accession:
GSE77107
ID:
200077107
11.

HMLER cells expressing either FOXC2 or a vector control

(Submitter supplied) We used microarrays to investigate the transcription profile of FOXC2 expression in a human mammary epithelial cell line.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE44335
ID:
200044335
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Supplemental Content

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