Similar studies for GEO DataSets (Select 200206806) - GEO DataSets

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Items: 14

Select item 2002068061.

Gene expression from microdissected glomeruli and tubulointerstitium of NZM2328 mice

(Submitter supplied) To characterize molecular profiles through the development of lupus nephritis and identify risk factors for end organ damage, we carried out gene expression analysis of microdissected kidneys from lupus-prone NZM2328 mice. We identified a continuum of inflammatory processes associated with the progression from acute inflammatory to chronic destructuve disease initiated in the glomeruli and progressing to the tubulointerstitium. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL20775 GPL1261
61 Samples

Download data: CEL

Series

Accession:: GSE206806

ID:: 200206806

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000374632.

Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Third-party reanalysis

Platforms:: GPL14663 GPL11670
110 Samples

Download data: CEL

Series

Accession:: GSE37463

ID:: 200037463

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Select item 2000374603.

Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis [Glomeruli]

(Submitter supplied) Expression data from human with IgA nephropathy (IgAN) and hypertensive nephropathy (HT) We used microarrays to analyze the transcriptome of microdissected renal biopsies from patients with IgAN and HT

Organism:: Homo sapiens

Type:: Expression profiling by array; Third-party reanalysis

Platforms:: GPL14663 GPL11670
69 Samples

Download data: CEL, TXT, XLSX

Series

Accession:: GSE37460

ID:: 200037460

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Select item 2000374554.

Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis[Tubulointerstitial]

(Submitter supplied) Expression data from human with hypertensive nephropathy (HT) We used microarrays to analyze the transcriptome of microdissected renal biopsies from patients with HT

Organism:: Homo sapiens

Type:: Expression profiling by array; Third-party reanalysis

Platforms:: GPL14663 GPL11670
41 Samples

Download data: CEL, TXT, XLSX

Series

Accession:: GSE37455

ID:: 200037455

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Select item 2000325925.

Human and mouse lupus nephritis cross-species transcriptional analysis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL14663 GPL7546
150 Samples

Download data: CEL

Series

Accession:: GSE32592

ID:: 200032592

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Select item 2000325916.

Expression data from human with lupus nephritis (LN)

(Submitter supplied) Nephritis (LN) is a serious manifestation of SLE. Therapeutic studies in mouse LN models do not always predict outcomes of human therapeutic trials, raising concerns about the human relevance of these models. In this study we used an unbiased transcriptional network approach to define similarities and differences between three lupus models and human LN. Affymetrix-based expression profiles were analyzed using Genomatix Bibliosphere software and transcriptional networks were compared using the Tool for Approximate LargE graph matching (TALE). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14663
93 Samples

Download data: CEL, TXT

Series

Accession:: GSE32591

ID:: 200032591

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Select item 2000325837.

Expression data from lupus NZB/W, NZM2410, NZW/BXSB mouse kidneys prenephritic and nephritic.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7546
57 Samples

Download data: CEL, TXT

Series

Accession:: GSE32583

ID:: 200032583

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Select item 2001133428.

Nanostring Immunology V2 panel comparing expression in kidney tissue from lupus nephritis patients at diagnosis (A) and at flare (B)

(Submitter supplied) The purpose of the experiment was to compare the transcriptional profile of lupus nephritis kidney tissue at a first flare and expression at a repeated lupus nephritis episode. All samples were laser microdissected into glomerular and tubular compartments and samples were ran in different cartridges.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21847
72 Samples

Download data: TXT

Series

Accession:: GSE113342

ID:: 200113342

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Select item 2000864449.

Characterization of mouse models of lupus nephritis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
216 Samples

Download data: CEL

Series

Accession:: GSE86444

ID:: 200086444

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Select item 20008642510.

Kidney gene expression profiles from a lupus nephritis mouse model: SNF1 (SWR X NZB F1) mice treated with pristane

(Submitter supplied) We characterized the longitudinal gene expression profiles of kidneys from a novel lupus model nephritis: SNF1 (SWR X NZB F1) mice treated with pristane. Genes from biological processes such as IFN response, complement, Fc gamma receptors, immune recruitment, innate immune pattern recognition, antibody response and fibrosis,were upregulated in diseased kidneys.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
95 Samples

Download data: CEL

Series

Accession:: GSE86425

ID:: 200086425

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Select item 20008642411.

Whole blood gene expression profiles from a lupus nephritis mouse model: SNF1 (SWR X NZB F1) mice treated with pristane

(Submitter supplied) We characterized the longitudinal gene expression profiles of whole blood from a novel lupus model nephritis: SNF1 (SWR X NZB F1) mice treated with pristane. Genes from interferon, plasma cell, neutrophil, T-cell and protein synthesis signatures were differentially expressed in the pristane-SNF1 model compared to the untreated matched control animals.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
88 Samples

Download data: CEL

Series

Accession:: GSE86424

ID:: 200086424

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Select item 20008642312.

Kidney gene expression profiles from a lupus nephritis mouse model: NZB X NZW F1 (BWF1) mice treated with IFN-alpha with adenovirus delivery.

(Submitter supplied) We characterized the longitudinal gene expression profiles of kidneys from a lupus model nephtiris: NZB X NZW F1 (BWF1) mice treated with IFN-alpha using adenovirus delivery. Genes from biological processes such as IFN response, complement, Fc gamma receptors, immune recruitment, innate immune pattern recognition, antibody response and fibrosis,were upregulated in diseased kidneys.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
33 Samples

Download data: CEL

Series

Accession:: GSE86423

ID:: 200086423

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Select item 20017542413.

CRAC channel controls the differentiation of pathogenic B cells in lupus nephritis

(Submitter supplied) Systemic lupus erythematous (SLE) is a prototype of autoimmune disease. Lupus nephritis (LN) is one of the most serious complications of SLE. The development of autoreactive B cells and the production of autoantibodies have been critical for the initiation and progression of LN. Store-operated Ca2+ entry (SOCE) is the main Ca2+ influx pathway in lymphocytes and is essential for immune response . SOCE is mediated by Ca2+ release-activated Ca2+ (CRAC) channels which are comprised of stromal interaction molecule (STIM) and calcium release-activated calcium modulators (ORAI) . more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE175424

ID:: 200175424

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Select item 20015540514.

Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resembles lymph nodes in gene signature.

(Submitter supplied) Immune aggregates organized as tertiary lymphoid structures (TLS) are observed within kidneys of systemic lupus erythematosus (SLE) patients with lupus nephritis (LN). We characterized renal TLS in lupus-prone (NZBxNZW) F1 mice with respect to cell composition and vessel formation. Ribonucleic acid (RNA) sequencing was performed on transcriptomes isolated from Lymph nodes (LyN), macro-dissected TLS from kidneys, and total kidneys of mice at different disease stages by using Ion Torrent Personal Genome Machine (Ion PGM) and RNAseq from Illumina. more...