Similar studies for GEO DataSets (Select 200212273) - GEO DataSets

Select item 2002122731.

Analyze the mechanism of polyploidization of proximal tubular cells (PTC) in the unilateral ischemia reperfusion injury model of acute kidney injury (AKI) in mice

(Submitter supplied) We found that PTC undergo polyploidization immediately after AKI induced by ischemia. To identify the mechanism controlling polyploidization of PTC, we generated single-cell RNA sequencing (scRNAseq) datasets from healthy mouse kidneys, 2 and 30 days after ischemia reperfusion injury. We found that polyploid PTC become hypertrophic and undergo polyploidization in a YAP1-related manner. In particular, YAP1 controls polyploidization of PTC via E2f7, E2f8 and Akt1. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: TAR

Series

Accession:: GSE212273

ID:: 200212273

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Select item 2002426952.

Identify and characterize the polyploidization process of primary human proximal tubular cells (hPTC) [scRNA-seq]

(Submitter supplied) We generated single-cell RNA sequencing (scRNAseq) datasets of primary cultures of human proximal tubular cells stimulated with TGF-β1 or vehicle. Following TGF-β1 stimulation, hPTC expressed TGF-β1 and its downstream targets. Moreover, TGF-β1-treated hPTC were characterized by a differential expression of pro-fibrotic genes, which we had recently showed to be characteristic of polyploid hPTC and were enriched with hypertrophy, indicative of cell polyploidization.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE242695

ID:: 200242695

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Select item 2002122753.

Identify and characterize the polyploidization process of primary human proximal tubular cells (hPTC)

(Submitter supplied) We generated single-cell RNA sequencing (scRNAseq) datasets of primary cultures of human proximal tubular cells at different passages which we have found to contain a polyploid fraction. Within hPTC clusters, we found genes previously associated with different phases of endoreplication-mediated polyploidy and established that YAP1 controls the polyploidization process of hPTC. These observations were verified by treating hPTC with verteporfin (a YAP1 inhibitor), YAP1 silencing and by quantifying the expression of YAP1 downstream targets in sorted polyploid hPTC

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
3 Samples

Download data: TAR

Series

Accession:: GSE212275

ID:: 200212275

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Select item 2001409884.

Epigenetic changes of pericytes after ischemia-reperfusion renal injury

(Submitter supplied) Analysis of epigenetic changes of pericytes after ischemia-reperfusion renal injury. The hypothesis tested in the present study was that epigenetic change develope in pericytes after acute kidney injury. This phenotype change would cause pericyte to be more proliferative and profibrotic. Results provide important information of the epigenetic change of pericytes, such as specific mechano-responsive genes, up-regulated specific proliferative and profibrotic functions.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
15 Samples

Download data: TXT, XLSX

Series

Accession:: GSE140988

ID:: 200140988

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000986225.

Transcriptome profile of a murine renal bilateral ischemia reperfusion model 2 hours to 12 months post injury

(Submitter supplied) Acute kidney injury (AKI) is associated with an increased risk of chronic kidney disease (CKD). To extend our understanding of renal repair, and its limits, we performed a detailed molecular characterization of a murine ischemia reperfusion injury (IRI) model for 12 months post injury. RNA-seq analysis highlights a cascade of temporal specific gene expression patterns related to tubular injury/repair, fibrosis, innate and adaptive immunity.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL13112
49 Samples

Download data: XLSX

Series

Accession:: GSE98622

ID:: 200098622

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Select item 2002140246.

Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney

(Submitter supplied) Mouse E18.5 wildtype kidney single-cell reference.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: MTX, TSV

Series

Accession:: GSE214024

ID:: 200214024

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Select item 2001986217.

Single-cell transcriptional profiling of advanced renal fibrosis identifies novel specific fibroblast marker and disease target

(Submitter supplied) Dissecting the molecular and cellular nature of advanced renal fibrosis is principal for mechanistic understanding of chronic kidney disease (CKD) and developing targeted strategies against its progression. Aberrant renal fibroblast activation and unresolved tubular epithelial injury are key contributors to excessive extracellular matrix (ECM) production and kidney function loss. However, the transcriptional and cellular identities of activated renal fibroblasts remain poorly characterized. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
11 Samples

Download data: MTX, TSV

Series

Accession:: GSE198621

ID:: 200198621

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