Similar studies for GEO DataSets (Select 200213210) - GEO DataSets

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Items: 11

Select item 2002132101.

Transcriptomics of AML core bone marrow biopsies reveals distinct therapy response-specific osteo-mesenchymal profiles by RNA-seq and microarray analysis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL20301 GPL23126
44 Samples

Download data: CEL, TXT

Series

Accession:: GSE213210

ID:: 200213210

Select item 2002130562.

Transcriptomics of AML core bone marrow biopsies reveals distinct therapy response-specific osteo-mesenchymal profiles [microarray]

(Submitter supplied) While the bone marrow (BM) microenvironment is significantly remodeled in acute myeloid leukemia (AML), our understanding of chemotherapy-induced changes within the BM stroma and their involvement in disease recurrence remains limited. Molecular insight into AML-specific alterations in the microenvironment has been historically limited by the analysis of liquid marrow aspirates rather than core biopsies that contain solid-phase BM stroma with non-hematopoietic cells supporting hematopoiesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23126
22 Samples

Download data: CEL

Series

Accession:: GSE213056

ID:: 200213056

Select item 2002126153.

Transcriptomics of AML core bone marrow biopsies reveals distinct therapy response-specific osteo-mesenchymal profiles

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
22 Samples

Download data: TXT

Series

Accession:: GSE212615

ID:: 200212615

PubMed Similar studies

Select item 2000848814.

Transcriptional Alterations in Bone Marrow Mesenchymal Stromal Cells derived from Acute Myeloid Leukemia patients (AML BM-MSC)

(Submitter supplied) The aim of the study was to get insights into transcriptional alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients We compared the global gene expression profile from AML BM-MSC (n=19) to healthy donor (HD) controls (HD BM-MSC n=4)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
23 Samples

Download data: CEL

Series

Accession:: GSE84881

ID:: 200084881

Select item 2000796955.

Molecular alterations in bone marrow mesenchymal stromal cells (BM-MSC) derived from acute myeloid leukemia patients (AML)

(Submitter supplied) Genome wide methylation profiling of BM-MSC derived from AML patients in comparison to healthy donor controls using Illumina Infinium HumanMethylation450 Beadchip

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
44 Samples

Download data: IDAT, TXT

Series

Accession:: GSE79695

ID:: 200079695

Select item 2001554416.

Self-production of IFN-γ by acute myeloid leukemia cells remodels mesenchymal stromal bone marrow cells

(Submitter supplied) Acute myeloid leukemia (AML) cells can shape their niche to their own advantage, perturbing bone marrow stromal and immune landscape. Indeed, AML cells provide the signals, among which inflammatory mediators are crucial, since they are able to subvert mesenchymal stromal cell (MSC) funtions. In particular, IFN-γhigh AML cells hold an inflammatory/immune modulating signature distinct from IFN-γlow cases. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23159
16 Samples

Download data: CEL

Series

Accession:: GSE155441

ID:: 200155441

Select item 2000927787.

Niche targeting enhances endogenous healthy hematopoiesis in acute myeloid leukemia

(Submitter supplied) Global gene expression comparison between mesenchymal stem cells (MSCs) purified from the BM of AML patients versus healthy donors.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
12 Samples

Download data: CEL

Series

Accession:: GSE92778

ID:: 200092778

Select item 2000376428.

Prognostic gene signature for AML

(Submitter supplied) Acute myeloid leukemia (AML) is a heterogeneous disease in respect of molecular aberrations and prognosis. We used gene expression profiling of 562 patients treated in the German AMLCG 1999 trial to develop a gene signature that predicts survival in AML.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL96 GPL570 GPL97
984 Samples

Download data: CEL, TXT

Series

Accession:: GSE37642

ID:: 200037642

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001387029.

Highly multiplexed proteomic assessment of the human bone marrow microenvironment reveals elevated levels of CCL23 in acute myeloid leukemia

(Submitter supplied) Acute myeloid leukemia (AML) is a genetically heterogeneous disease that is characterized by abnormal clonal proliferation of myeloid progenitor cells found predominately within the bone marrow (BM) and blood. Recent studies suggest that genetic and phenotypic alterations in the BM microenvironment support leukemogenesis and allow leukemic cells to survive and evade chemotherapy-induced death. However, despite substantial evidence indicating the role of tumor-host interactions in AML pathogenesis, little is known about the complex microenvironment of the BM. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
19 Samples

Download data: CSV

Series

Accession:: GSE138702

ID:: 200138702

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20016942810.

Targeting mesenchymal stromal cells plasticity to reroute acute myeloid leukemia course

(Submitter supplied) MSC and AML dual targeting to treat pediatric AML Bone marrow (BM) microenvironment supports the regulation of normal hematopoiesis through a finely tuned balance of self-renewal and differentiation processes, cell-cell interaction and secretion of cytokines that during leukemogenesis are severely compromised and favor tumor cell growth. In pediatric acute myeloid leukemia (AML), chemotherapy is the standard of care, but still >30% of patients relapse. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
21 Samples

Download data: CEL

Series

Accession:: GSE169428

ID:: 200169428

Select item 20023568811.

Genome wide CRISPR screen in AML chemotherapy resistance.

(Submitter supplied) Chemoresistance is the leading cause of acute myeloid leukemia (AML)-related deaths, and elucidation of the mechanisms of AML chemoresistance is necessary to effectively target this process. Here, we performed genome wide CRISPR-Cas9 screening to identify key molecules regulating AML chemoresistance.