Similar studies for GEO DataSets (Select 200221151) - GEO DataSets

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Items: 2

Select item 2002211511.

Beneficial and detrimental genes in the cellular response to replication arrest

(Submitter supplied) DNA replication is essential for all living organisms. Several events can disrupt replication, including DNA damage (e.g., pyrimidine dimers, crosslinking) and so-called “roadblocks” (e.g., DNA-binding proteins or transcription). Bacteria have several well-characterized mechanisms for repairing damaged DNA and then restoring functional replication forks. However, little is known about the repair of stalled or arrested replication forks in the absence of chemical alterations to DNA. more...

Organism:: Bacillus subtilis subsp. subtilis

Type:: Other

Platform:: GPL32956
10 Samples

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Series

Accession:: GSE221151

ID:: 200221151

PubMed Full text in PMC Similar studies

Select item 2000046732.

Analysis of the transcriptional response to DNA damage and replication arrest

(Submitter supplied) Our results indicate that the transcriptional responses to HPUra, MMC, and UV are only partially overlapping. recA is the major transcriptional regulator under all of the tested conditions and LexA appears to directly repress expression of 63 genes in 26 operons, including the 18 operons previously identified as LexA targets. MMC and HPUra treatments caused induction of an integrative and conjugative element (ICEBs1) and resident prophages (PBSX and SPß), which affected expression of many host genes. more...