GEO DataSets

(Submitter supplied) Abnormal expression of circadian genes is known to be engage in tumor initiation and progression through disrupting rhythms of cellular processes. Here, we determined a significant role of the core circadian transcription factor ARNTL2 in nasopharyngeal carcinoma metastasis. To further investigate the downstream targets of ARNTL2 in nasopharyngeal carcinoma, chromatin immunoprecipitation (ChIP) sequencing was performed in ARNTL2-overexpression HONE1 cell.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL24676

2 Samples

Download data: BW, NARROWPEAK, TXT

(Submitter supplied) Abnormal expression of circadian genes is known to be engage in tumor initiation and progression through disrupting rhythms of cellular processes. Here, we determined a significant role of the core circadian gene ARNTL2 in nasopharyngeal carcinoma metastasis. To further investigate the underlying mechanism of ARNTL2 in nasopharyngeal carcinoma, High-throughput RNA sequencing was performed in ARNTL2-knockdown HONE1 cell.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

6 Samples

Download data: TXT

(Submitter supplied) Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer with highly aggressive and metastatic potential, and distant metastasis is the main reason for treatment failure. The underlying molecular mechanisms of NPC metastasis remains poorly understood. Here, we have identified S100 calcium binding protein A14 (S100A14) as a functional regulator suppressed NPC metastasis via inhibiting NF-kB signaling and reversing epithelial-mesenchymal transition (EMT). more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

4 Samples

Download data: XLS

(Submitter supplied) By using NGS-derived retinal transcriptome profiling (RNA-seq) to compare the gene expression profiling between 4 differently treated NPC cells

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

4 Samples

Download data: TXT

(Submitter supplied) Epstein-Barr virus (EBV) has been etiologically linked to human malignancies including Nasopharyngeal Carcinoma (NPC). Although EBV-encoded miRNAs have been shown to contribute to viral latency, host cell survival and immune evasion, their direct impact on cancer progression in their human host remains unclear. In the current study, based on a miRNA expression profiling analysis of a larger number of clinical specimens using a miRNA array platform containing human, EBV and other species miRNA probes., we found that some EBV-miR-BARTs were highly expressed in NPC. more...

Organism:

Homo sapiens; Mus musculus; Rattus norvegicus; Macacine gammaherpesvirus 4; Human gammaherpesvirus 8; Betapolyomavirus macacae

Type:

Non-coding RNA profiling by array

Platform:

GPL16414

40 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus; Macacine gammaherpesvirus 4; Human gammaherpesvirus 8; Betapolyomavirus macacae; Homo sapiens; Mus musculus

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by array

Platforms:

GPL11154 GPL16414

44 Samples

Download data: GPR, TXT

(Submitter supplied) Long non-coding RNAs (lncRNAs) play important roles in the tumorigenesis and progression of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms in nasopharyngeal carcinogenesis (NPC) are largely unknown. In this study, we used the microarray analysis to study the different expression profiles of lncRNAs and mRNAs in human nasopharyngeal carcinoma tissues. We performed genome-wide lncRNAs expression in 3 pairs of NPC and normal nasopharynx tissues and identified 384 dysregulated lncRNAs (fold change ≥2 and P <0.05).

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL16956

6 Samples

Download data: TXT

(Submitter supplied) A microarray analysis was performed on the vector and over-expressing RRM2-c2orf48 NPC cell samples(CNE2-PMSCV-Vector and CNE2-PMSCV-RRM2-c2orf48). Total RNA was extracted from 1 × 106 cells using TRIzol reagent and was further purified using a Qiagen RNeasy Mini Kit according to the manufactures’ instructions. RNA quality was assessed by formaldehyde agarose gel electrophoresis and was quantitated spectrophotometrically. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

2 Samples

Download data: CEL

(Submitter supplied) Analysis of nasopharyngeal carcinoma cell line HONE1 following knockdown of SHROOM2 gene We used microarrays to detail the global gene expression in tissues from HONE1 cells with or without SHROOM2 knockdown.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

2 Samples

Download data: CEL