Similar studies for GEO DataSets (Select 200243982) - GEO DataSets

Select item 2002439821.

Deciphering bat influenza H18N11 infection dynamics in Jamaican fruit bats on a single cell level

(Submitter supplied) Jamaican fruit bats (Artibeus jamaicensis) naturally harbor a wide range of viruses of human relevance. These infections are typically mild in bats, suggesting unique features of their immune system. To better understand the immune response to viral infections in bats, we infected Jamaican fruit bats with the bat-derived influenza A virus H18N11. Using comparative single-cell RNA sequencing, we generated a single-cell atlas of the Jamaican fruit bat intestine and mesentery, the target organs of infection. more...

Organism:: Artibeus jamaicensis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33786
28 Samples

Download data: H5

Series

Accession:: GSE243982

ID:: 200243982

PubMed Full text in PMC Similar studies

Select item 2001961222.

MHC class II proteins mediate cross-species entry of bat influenza viruses

(Submitter supplied) Zoonotic influenza A viruses of avian origin can cause severe disease in individuals, or even global pandemics, and thus pose a threat to human populations. Waterfowl and shorebirds are believed to be the reservoir for all influenza A viruses, but this has recently been challenged by the identification of novel influenza A viruses in bats. The major bat influenza A virus envelope glycoprotein, haemagglutinin, does not bind the canonical influenza A virus receptor, sialic acid or any other glycan, despite its high sequence and structural homology with conventional haemagglutinins. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL18573
2 Samples

Download data: TXT

Series

Accession:: GSE196122

ID:: 200196122

PubMed Similar studies

Select item 2001159043.

Unique transcriptional architecture in airway epithelial cells and macrophages shapes distinct responses following influenza virus infection ex vivo.

(Submitter supplied) Airway epithelial cells and macrophages differ markedly in their responses to influenza A virus (IAV) infection. To investigate transcriptional responses underlying these differences, purified subsets of type II airway epithelial cells (ATII) and alveolar macrophages (AM) recovered from the lungs of mock- or IAV-infected mice were subjected to RNA sequencing. In the absence of infection, AM predominantly expressed genes related to immunity whereas ATII expressed genes consistent with their physiological roles in the lung. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
96 Samples

Download data: TXT

Series

Accession:: GSE115904

ID:: 200115904

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000570084.

Transcriptomics of murine ex vivo isolated alveolar type 2 epithelial cells from Influenza A respiratory infection

(Submitter supplied) Background: Influenza A virus (IAV) infections periodically cause substantial morbidity and mortality in the human population. In the lung, the primary targets for IAV replication are type II alveolar epithelial cells (AECII), which are increasingly recognized for their immunological potential. However, our knowledge of the role of AECII in anti-IAV immunity is incomplete and their in vivo response to infection has not been evaluated. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
28 Samples

Download data: CEL

Series

Accession:: GSE57008

ID:: 200057008

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002181995.

Comparative analysis of innate immune responses to viral infection among animals

(Submitter supplied) Bats harbour various viruses without severe symptoms and act as natural reservoirs. This tolerance of bats toward viral infections is assumed to be originated from the uniqueness of their immune system. However, how the innate immune response varies between primates and bats remains unclear. To illuminate differences in innate immune responses among animal species, we performed a comparative single-cell RNA-sequencing analysis on peripheral blood mononuclear cells (PBMCs) from four species including Egyptian fruit bats inoculated with various infectious stimuli.

Organism:: Rousettus aegyptiacus; Macaca mulatta; Homo sapiens; Pan troglodytes

Type:: Expression profiling by high throughput sequencing

4 related Platforms
16 Samples

Download data: H5

Series

Accession:: GSE218199

ID:: 200218199

PubMed Full text in PMC Similar studies

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